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Aliases for MIR4707 Gene

Subcategory (RNA class) for MIR4707 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4707 Gene

  • MicroRNA 4707 2 3
  • HAUS4 4 5
  • HAUS Augmin Like Complex Subunit 4 5
  • Hsa-Mir-4707 3
  • C14orf94 4
  • Mir-4707 3

External Ids for MIR4707 Gene

Previous GeneCards Identifiers for MIR4707 Gene

  • GC14U901292
  • GC14M023430
  • GC14M022960
  • GC14M022948

Summaries for MIR4707 Gene

Entrez Gene Summary for MIR4707 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4707 Gene

MIR4707 (MicroRNA 4707) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. An important paralog of this gene is ENSG00000259132.

UniProtKB/Swiss-Prot for MIR4707 Gene

  • Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4707 Gene

Genomics for MIR4707 Gene

Regulatory Elements for MIR4707 Gene

Enhancers for MIR4707 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F023067 1.4 Ensembl ENCODE 10.5 -113.3 -113302 5.9 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 PSMB11 PSMB5 C14orf119 ACIN1 C14orf93 CEBPE AJUBA HAUS4 MIR4707 SLC7A8
GH14F023060 0.9 ENCODE 10.5 -105.6 -105610 4.3 PKNOX1 KLF17 SIN3A PLRG1 ZBTB40 DNMT3B ZNF2 RFX5 GLIS2 ZNF366 EFS PSMB11 PSMB5 ACIN1 C14orf93 C14orf119 AJUBA HAUS4 MIR4707 RNF212B
GH14F022955 1.1 ENCODE 0.8 +0.6 557 2.6 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 HAUS4 C14orf119 AJUBA PSMB5 PSMB11 CDH24 C14orf93 LOC102724814 ACIN1 MIR4707
GH14F022976 1.6 FANTOM5 ENCODE 0.3 -22.7 -22745 7.6 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 PRMT5 HAUS4 LOC102724814 PABPN1 MMP14 LOC105370399 RN7SKP205 LOC105370409 TRAV37 LINC00596
GH14F022965 1 ENCODE 0.4 -9.3 -9300 1.7 ARID4B ZNF48 ZNF121 SLC30A9 PAF1 SP5 ZHX2 MXD4 KAT8 NFIL3 HAUS4 PRMT5 CDH24 RBM23 MIR4707 ENSG00000259132
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4707 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4707 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000415260 361 1601 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9

Genomic Location for MIR4707 Gene

Chromosome:
14
Start:
22,946,228 bp from pter
End:
22,957,161 bp from pter
Size:
10,934 bases
Orientation:
Minus strand

Genomic View for MIR4707 Gene

Genes around MIR4707 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4707 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4707 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4707 Gene

Proteins for MIR4707 Gene

  • Protein details for MIR4707 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6D7-HAUS4_HUMAN
    Recommended name:
    HAUS augmin-like complex subunit 4
    Protein Accession:
    Q9H6D7
    Secondary Accessions:
    • B7WP17
    • D3DS34
    • Q86T15
    • Q86T16
    • Q86U43
    • Q9NX59

    Protein attributes for MIR4707 Gene

    Size:
    363 amino acids
    Molecular mass:
    42400 Da
    Quaternary structure:
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    • Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.
    SequenceCaution:
    • Sequence=CAD62584.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR4707 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4707 Gene

Post-translational modifications for MIR4707 Gene

  • Ubiquitination at Lys 201 and Lys 360
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIR4707 Gene

Domains & Families for MIR4707 Gene

Gene Families for MIR4707 Gene

Protein Domains for MIR4707 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H6D7

UniProtKB/Swiss-Prot:

HAUS4_HUMAN :
  • Belongs to the HAUS4 family.
Family:
  • Belongs to the HAUS4 family.
genes like me logo Genes that share domains with MIR4707: view

No data available for Suggested Antigen Peptide Sequences for MIR4707 Gene

Function for MIR4707 Gene

Molecular function for MIR4707 Gene

UniProtKB/Swiss-Prot Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Gene Ontology (GO) - Molecular Function for MIR4707 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MIR4707: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4707 Gene

Localization for MIR4707 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4707 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. {ECO:0000269 PubMed:19369198, ECO:0000269 PubMed:19427217}.

Gene Ontology (GO) - Cellular Components for MIR4707 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MIR4707: view

No data available for Subcellular locations from COMPARTMENTS for MIR4707 Gene

Pathways & Interactions for MIR4707 Gene

genes like me logo Genes that share pathways with MIR4707: view

Gene Ontology (GO) - Biological Process for MIR4707 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0051225 spindle assembly IMP --
GO:0051297 centrosome organization IMP --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with MIR4707: view

No data available for SIGNOR curated interactions for MIR4707 Gene

Transcripts for MIR4707 Gene

mRNA/cDNA for MIR4707 Gene

(22) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4707 Gene

No ASD Table

Relevant External Links for MIR4707 Gene

GeneLoc Exon Structure for
MIR4707
ECgene alternative splicing isoforms for
MIR4707

Expression for MIR4707 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4707 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4707 Gene

This gene is overexpressed in Whole Blood (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR4707 Gene:

MIR4707
genes like me logo Genes that share expression patterns with MIR4707: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4707 Gene

Orthologs for MIR4707 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4707 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAUS4 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Haus4 35
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii haus4 35
  • 32 (a)
OneToMany
Species where no ortholog for MIR4707 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4707 Gene

ENSEMBL:
Gene Tree for MIR4707 (if available)
TreeFam:
Gene Tree for MIR4707 (if available)

Paralogs for MIR4707 Gene

Paralogs for MIR4707 Gene

Pseudogenes.org Pseudogenes for MIR4707 Gene

genes like me logo Genes that share paralogs with MIR4707: view

Variants for MIR4707 Gene

Sequence variations from dbSNP and Humsavar for MIR4707 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1060865 -- 22,956,492(-) AGGGG(G/T)GGACG intron-variant, downstream-variant-500B
rs115335261 -- 22,957,343(+) GTAAT(G/T)GCTAA upstream-variant-2KB
rs11549680 -- 22,956,945(-) CGCCT(G/T)GAGAG downstream-variant-500B, utr-variant-5-prime
rs117593517 -- 22,957,336(+) AATGG(C/T)GGTAA upstream-variant-2KB
rs12880925 -- 22,957,213(+) TCCCA(A/G)CGCCC upstream-variant-2KB

Relevant External Links for MIR4707 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4707

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4707 Gene

Disorders for MIR4707 Gene

Relevant External Links for MIR4707

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4707

No disorders were found for MIR4707 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4707 Gene

Publications for MIR4707 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (PMID: 19369198) Uehara R. … Goshima G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 4 64
  5. HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity. (PMID: 19427217) Lawo S. … Pelletier L. (Curr. Biol. 2009) 4 64

Products for MIR4707 Gene

Sources for MIR4707 Gene

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