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Aliases for MIR4700 Gene

Subcategory (RNA class) for MIR4700 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4700 Gene

  • MicroRNA 4700 2 3
  • UNC119B 4 5
  • Unc-119 Lipid Binding Chaperone B 5
  • Hsa-Mir-4700 3
  • Mir-4700 3

External Ids for MIR4700 Gene

Previous GeneCards Identifiers for MIR4700 Gene

  • GC12U901590
  • GC12P121196
  • GC12P121211
  • GC12P121223
  • GC12P120723

Summaries for MIR4700 Gene

Entrez Gene Summary for MIR4700 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4700 Gene

MIR4700 (MicroRNA 4700) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Organelle biogenesis and maintenance and Cargo trafficking to the periciliary membrane. An important paralog of this gene is UNC119.

UniProtKB/Swiss-Prot for MIR4700 Gene

  • Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4700 Gene

Genomics for MIR4700 Gene

Regulatory Elements for MIR4700 Gene

Enhancers for MIR4700 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F121657 1.4 Ensembl ENCODE 29.9 +948.6 948566 3.6 HDGF PKNOX1 ARNT CREB3L1 SIN3A ZNF2 ZNF766 ZNF302 ZNF548 ZNF263 ZCCHC8 SETD1B KNTC1 ANAPC5 ENSG00000272849 PSMD9 LINC01089 MIR4700 ENSG00000258435 ENSG00000201945
GH12F120683 1.2 ENCODE 22 -23.0 -22988 7.3 CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ANAPC5 GCN1 ACADS MIR4700 C12orf43 RPL31P52 MLEC ENSG00000256569 NME2P1 ENSG00000255946
GH12F120858 1 Ensembl 25 +148.5 148466 0.6 CREB3L1 ZNF133 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 ZNF766 ZNF143 MIR4700 SPPL3 C12orf43 ENSG00000255946 ENSG00000256569 ACADS UNC119B P2RX4 ARF1P2
GH12F120528 1.2 ENCODE 20.2 -181.0 -180991 2.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 GCN1 COQ5 ANAPC5 RPL31P52 C12orf43 NME2P1 MIR4700 GATC ENSG00000256695 RPL12P33
GH12F120290 1.2 ENCODE 19.8 -418.2 -418206 3.4 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 GCN1 NME2P1 MIR4700 RAB35 SRSF9 RPL31P52 SIRT4 C12orf43 PRKAB1 RPL29P24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4700 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4700 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001781795 365 1601 PKNOX1 ZNF493 ZFP64 ARID4B SIN3A ZSCAN9 DNMT3B YY1 ZNF766 GLIS2
ENSR00000438186 1465 201 ZNF766 MLLT1 PRDM1

Genomic Location for MIR4700 Gene

Chromosome:
12
Start:
120,710,435 bp from pter
End:
120,723,640 bp from pter
Size:
13,206 bases
Orientation:
Plus strand

Genomic View for MIR4700 Gene

Genes around MIR4700 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4700 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4700 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4700 Gene

Proteins for MIR4700 Gene

  • Protein details for MIR4700 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIH7-U119B_HUMAN
    Recommended name:
    Protein unc-119 homolog B
    Protein Accession:
    A6NIH7

    Protein attributes for MIR4700 Gene

    Size:
    251 amino acids
    Molecular mass:
    28137 Da
    Quaternary structure:
    • Found in a complex with ARL3, RP2 and UNC119B; RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119B. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interacts with C5orf30; interaction only takes place when UNC119B is not liganded with myristoylated proteins.
    • Found in a complex with ARL3, RP2 and UNC119B; RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119B. Interacts with NPHP3 (when myristoylated). Interacts with CYS1 (when myristoylated). Interacts with C5orf30; interaction only takes place when UNC119B is not liganded with myristoylated proteins.

neXtProt entry for MIR4700 Gene

Post-translational modifications for MIR4700 Gene

  • Ubiquitination at Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4700 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR4700 Gene

Domains & Families for MIR4700 Gene

Gene Families for MIR4700 Gene

Protein Domains for MIR4700 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6NIH7

UniProtKB/Swiss-Prot:

U119B_HUMAN :
  • Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (PubMed:22085962).
  • Belongs to the PDE6D/unc-119 family.
Domain:
  • Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (PubMed:22085962).
Family:
  • Belongs to the PDE6D/unc-119 family.
genes like me logo Genes that share domains with MIR4700: view

No data available for Suggested Antigen Peptide Sequences for MIR4700 Gene

Function for MIR4700 Gene

Molecular function for MIR4700 Gene

UniProtKB/Swiss-Prot Function:
Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.

Gene Ontology (GO) - Molecular Function for MIR4700 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with MIR4700: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4700 Gene

Localization for MIR4700 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4700 Gene

Cell projection, cilium. Note=Enriched at the transition zone and extended into the proximal end of the cilium.

Gene Ontology (GO) - Cellular Components for MIR4700 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005929 cilium IEA --
GO:0035869 ciliary transition zone IDA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with MIR4700: view

No data available for Subcellular locations from COMPARTMENTS for MIR4700 Gene

Pathways & Interactions for MIR4700 Gene

genes like me logo Genes that share pathways with MIR4700: view

Gene Ontology (GO) - Biological Process for MIR4700 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030030 cell projection organization IEA --
GO:0042953 lipoprotein transport IDA --
GO:0060271 cilium assembly IMP --
genes like me logo Genes that share ontologies with MIR4700: view

No data available for SIGNOR curated interactions for MIR4700 Gene

Transcripts for MIR4700 Gene

mRNA/cDNA for MIR4700 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4700 Gene

No ASD Table

Relevant External Links for MIR4700 Gene

GeneLoc Exon Structure for
MIR4700
ECgene alternative splicing isoforms for
MIR4700

Expression for MIR4700 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4700 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4700 Gene:

MIR4700
genes like me logo Genes that share expression patterns with MIR4700: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4700 Gene

Orthologs for MIR4700 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4700 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UNC119B 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UNC119B 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UNC119B 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UNC119B 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Unc119b 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UNC119B 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves UNC119B 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UNC119B 35
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii unc119.1 35
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-119 35
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-119 35
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11065 35
  • 56 (a)
OneToMany
Species where no ortholog for MIR4700 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4700 Gene

ENSEMBL:
Gene Tree for MIR4700 (if available)
TreeFam:
Gene Tree for MIR4700 (if available)

Paralogs for MIR4700 Gene

Paralogs for MIR4700 Gene

genes like me logo Genes that share paralogs with MIR4700: view

Variants for MIR4700 Gene

Sequence variations from dbSNP and Humsavar for MIR4700 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1055059 -- 120,722,289(+) CCCAG(C/T)AGGAC upstream-variant-2KB, utr-variant-3-prime
rs1055070 -- 120,723,245(+) CTGAC(G/T)CCTCA nc-transcript-variant, utr-variant-3-prime
rs11065225 -- 120,721,936(+) CCTCA(A/G)ATGGG upstream-variant-2KB, utr-variant-3-prime
rs111300193 -- 120,722,762(+) GATCC(A/G)AGTTT upstream-variant-2KB, utr-variant-3-prime
rs112701930 -- 120,721,832(+) GCTGC(A/G)GGGGA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4700 Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV gain 19592680

Relevant External Links for MIR4700 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4700

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4700 Gene

Disorders for MIR4700 Gene

Relevant External Links for MIR4700

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4700

No disorders were found for MIR4700 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4700 Gene

Publications for MIR4700 Gene

  1. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64

Products for MIR4700 Gene

Sources for MIR4700 Gene

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