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Aliases for MIR4691 Gene

Subcategory (RNA class) for MIR4691 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4691 Gene

  • MicroRNA 4691 2 3
  • NDUFS8 4 5
  • NADH:Ubiquinone Oxidoreductase Core Subunit S8 5
  • NADH-Ubiquinone Oxidoreductase 23 KDa Subunit 4
  • Complex I-23kD 4
  • Hsa-Mir-4691 3
  • TYKY Subunit 4
  • EC 1.6.99.5 61
  • EC 1.6.99.3 4
  • EC 1.6.5.3 4
  • Mir-4691 3
  • CI-23kD 4

External Ids for MIR4691 Gene

Previous GeneCards Identifiers for MIR4691 Gene

  • GC11U901856
  • GC11P067805
  • GC11P067814

Summaries for MIR4691 Gene

Entrez Gene Summary for MIR4691 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4691 Gene

MIR4691 (MicroRNA 4691) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4691 include Leigh Syndrome. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

UniProtKB/Swiss-Prot for MIR4691 Gene

  • Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4691 Gene

Genomics for MIR4691 Gene

Regulatory Elements for MIR4691 Gene

Enhancers for MIR4691 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F068098 1 Ensembl ENCODE 11.9 +70.4 70388 4.8 MLX ZFP64 ZNF493 ARID4B DMAP1 YY1 SLC30A9 ZNF143 ZNF202 SP5 MRGPRF-AS1 MRGPRF ENSG00000261625 ENSG00000260808 RAD9A SSH3 FAM86C2P IGHMBP2 ENSG00000255031 TCIRG1
GH11F068089 1.3 Ensembl ENCODE 11.8 +60.2 60202 1.6 NR3C1 ZNF652 SPI1 GABPA TCIRG1 MIR4691 MIR7113 NDUFS8 GC11M068058 CHKA
GH11F068081 0.6 ENCODE 11.6 +51.1 51076 0.6 GATA3 ZNF687 DPF2 RAD21 TCIRG1 MIR4691 MIR7113 NDUFS8 GC11M068058 CHKA
GH11F068144 1 Ensembl ENCODE 11.4 +116.0 116042 4.9 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 KLF13 SP5 ENSG00000255031 TCIRG1 MIR4691 MIR7113 NDUFS8 ENSG00000255119 PIR54954 GC11M068148
GH11F068149 0.5 Ensembl ENCODE 11.4 +119.7 119689 1.3 MAX RAD21 GATA3 SCRT2 FOSL2 FOS SMARCE1 SCRT1 NRF1 CEBPB TCIRG1 MIR4691 MIR7113 NDUFS8 PIR54954 GC11M068148
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4691 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4691 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000564332 83 1801 HDGF ATF1 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A GLI4 DMAP1 ZNF48

Genomic Location for MIR4691 Gene

Chromosome:
11
Start:
68,030,617 bp from pter
End:
68,036,644 bp from pter
Size:
6,028 bases
Orientation:
Plus strand

Genomic View for MIR4691 Gene

Genes around MIR4691 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4691 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4691 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4691 Gene

Proteins for MIR4691 Gene

  • Protein details for MIR4691 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00217-NDUS8_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
    Protein Accession:
    O00217
    Secondary Accessions:
    • B2RB86
    • Q0VDA8

    Protein attributes for MIR4691 Gene

    Size:
    210 amino acids
    Molecular mass:
    23705 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Mammalian complex I is composed of 45 different subunits.
    • Mammalian complex I is composed of 45 different subunits.
    • Mammalian complex I is composed of 45 different subunits.

neXtProt entry for MIR4691 Gene

Selected DME Specific Peptides for MIR4691 Gene

O00217:
  • CPAQAITIEA
  • SPRFRGEHALRRYP

Post-translational modifications for MIR4691 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MIR4691 Gene

Gene Families for MIR4691 Gene

Protein Domains for MIR4691 Gene

Graphical View of Domain Structure for InterPro Entry

O00217

UniProtKB/Swiss-Prot:

NDUS8_HUMAN :
  • Contains 2 4Fe-4S ferredoxin-type domains.
  • Belongs to the complex I 23 kDa subunit family.
Domain:
  • Contains 2 4Fe-4S ferredoxin-type domains.
Family:
  • Belongs to the complex I 23 kDa subunit family.
genes like me logo Genes that share domains with MIR4691: view

No data available for Suggested Antigen Peptide Sequences for MIR4691 Gene

Function for MIR4691 Gene

Molecular function for MIR4691 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
UniProtKB/Swiss-Prot CatalyticActivity:
NADH + acceptor = NAD(+) + reduced acceptor.
UniProtKB/Swiss-Prot Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.

Enzyme Numbers (IUBMB) for MIR4691 Gene

Gene Ontology (GO) - Molecular Function for MIR4691 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS --
GO:0016491 oxidoreductase activity IEA --
GO:0016651 oxidoreductase activity, acting on NAD(P)H IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with MIR4691: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4691 Gene

Localization for MIR4691 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4691 Gene

Gene Ontology (GO) - Cellular Components for MIR4691 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005747 mitochondrial respiratory chain complex I NAS --
GO:0005759 mitochondrial matrix TAS --
GO:0016020 membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with MIR4691: view

No data available for Subcellular locations from COMPARTMENTS for MIR4691 Gene

Pathways & Interactions for MIR4691 Gene

genes like me logo Genes that share pathways with MIR4691: view

Gene Ontology (GO) - Biological Process for MIR4691 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS --
GO:0006979 response to oxidative stress IDA --
GO:0032981 mitochondrial respiratory chain complex I assembly IMP --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MIR4691: view

No data available for SIGNOR curated interactions for MIR4691 Gene

Transcripts for MIR4691 Gene

mRNA/cDNA for MIR4691 Gene

(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4691 Gene

No ASD Table

Relevant External Links for MIR4691 Gene

GeneLoc Exon Structure for
MIR4691
ECgene alternative splicing isoforms for
MIR4691

Expression for MIR4691 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4691 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4691 Gene:

MIR4691
genes like me logo Genes that share expression patterns with MIR4691: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4691 Gene

Orthologs for MIR4691 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4691 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFS8 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFS8 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufs8 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFS8 35 35
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia NDUFS8 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFS8 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFS8 35
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ndufs8a 35
  • 77 (a)
OneToMany
ndufs8b 35
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ND23 35
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T20H4.5 35
  • 64 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2781 35
  • 73 (a)
OneToOne
Species where no ortholog for MIR4691 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4691 Gene

ENSEMBL:
Gene Tree for MIR4691 (if available)
TreeFam:
Gene Tree for MIR4691 (if available)

Paralogs for MIR4691 Gene

No data available for Paralogs for MIR4691 Gene

Variants for MIR4691 Gene

Sequence variations from dbSNP and Humsavar for MIR4691 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs121912638 Pathogenic 68,033,216(+) GCTGC(A/G)CCGGT downstream-variant-500B, upstream-variant-2KB, reference, missense
rs121912639 Pathogenic 68,033,165(+) CTACC(C/T)GTTCG downstream-variant-500B, upstream-variant-2KB, reference, missense
rs146766138 Pathogenic 68,033,140(+) TGTTC(C/G/T)GGGAA downstream-variant-500B, upstream-variant-2KB, reference, missense
rs28939679 Pathogenic 68,033,147(+) GGAAC(C/T)GGCCA downstream-variant-500B, upstream-variant-2KB, reference, missense
rs397514618 Pathogenic 68,033,000(+) GGACT(C/G)AGCTC downstream-variant-500B, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR4691 Gene

Variant ID Type Subtype PubMed ID
dgv1221n100 CNV gain 25217958
dgv1981n54 CNV gain 21841781
dgv1983n54 CNV loss 21841781
esv2759835 CNV gain+loss 17122850
nsv468606 CNV gain 19166990
nsv468615 CNV loss 19166990
nsv469856 CNV gain 16826518
nsv469964 CNV loss 18288195
nsv555278 CNV loss 21841781
nsv555282 CNV loss 21841781
nsv825963 CNV gain 20364138
nsv8836 CNV gain 18304495
nsv951026 CNV deletion 24416366

Relevant External Links for MIR4691 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4691

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4691 Gene

Disorders for MIR4691 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4691 Gene - From: GeneCards

Disorder Aliases PubMed IDs
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NDUS8_HUMAN
  • Leigh syndrome (LS) [MIM:256000]: An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. {ECO:0000269 PubMed:9837812}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR4691

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4691
genes like me logo Genes that share disorders with MIR4691: view

No data available for Genatlas for MIR4691 Gene

Publications for MIR4691 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for MIR4691 Gene

Sources for MIR4691 Gene

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