Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4689 Gene

Subcategory (RNA class) for MIR4689 Gene


Quality Score for this RNA gene is


Aliases for MIR4689 Gene

  • MicroRNA 4689 2 3 5
  • Hsa-Mir-4689 3
  • Mir-4689 3

External Ids for MIR4689 Gene

Previous GeneCards Identifiers for MIR4689 Gene

  • GC01U903258
  • GC01M005925

Summaries for MIR4689 Gene

Entrez Gene Summary for MIR4689 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4689 Gene

MIR4689 (MicroRNA 4689) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4689 Gene

Genomics for MIR4689 Gene

Regulatory Elements for MIR4689 Gene

Enhancers for MIR4689 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F005896 0.5 FANTOM5 ENCODE 0.3 -34.5 -34516 1.5 NPHP4 CHD5 KCNAB2 GC01M005892 MIR4689
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4689 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4689 Gene

5,862,672 bp from pter
5,862,741 bp from pter
70 bases
Minus strand

Genomic View for MIR4689 Gene

Genes around MIR4689 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4689 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4689 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4689 Gene

Proteins for MIR4689 Gene

Post-translational modifications for MIR4689 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4689 Gene

Domains & Families for MIR4689 Gene

Gene Families for MIR4689 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4689: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4689 Gene

Function for MIR4689 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4689 Gene

Localization for MIR4689 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4689 Gene

Pathways & Interactions for MIR4689 Gene

SuperPathways for MIR4689 Gene

No Data Available

Interacting Proteins for MIR4689 Gene

Gene Ontology (GO) - Biological Process for MIR4689 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4689 Gene

Transcripts for MIR4689 Gene

mRNA/cDNA for MIR4689 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4689 Gene

No ASD Table

Relevant External Links for MIR4689 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4689 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4689 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4689 Gene:

genes like me logo Genes that share expression patterns with MIR4689: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4689 Gene

Orthologs for MIR4689 Gene

Evolution for MIR4689 Gene

Gene Tree for MIR4689 (if available)
Gene Tree for MIR4689 (if available)

No data available for Orthologs for MIR4689 Gene

Paralogs for MIR4689 Gene

No data available for Paralogs for MIR4689 Gene

Variants for MIR4689 Gene

Sequence variations from dbSNP and Humsavar for MIR4689 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs369162678 Likely pathogenic 5,863,955(+) CCTCC(A/G)GGAGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs139203183 Likely benign 5,863,416(+) AATAA(A/G)CATCC intron-variant, upstream-variant-2KB
rs374146357 Likely benign 5,863,916(+) CCGCA(A/G)CAGCT nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs763002637 Likely benign 5,864,350(+) ATGAG(C/T)GGCTG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon
rs115488133 Uncertain significance 5,864,423(+) TGAGA(C/T)GGACA nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR4689 Gene

Variant ID Type Subtype PubMed ID
nsv508723 CNV insertion 20534489
nsv545173 CNV gain 21841781
nsv545174 CNV loss 21841781
nsv831203 CNV loss 17160897

Relevant External Links for MIR4689 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4689 Gene

Disorders for MIR4689 Gene

Relevant External Links for MIR4689

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4689 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4689 Gene

Publications for MIR4689 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4689 Gene

Sources for MIR4689 Gene

Loading form....