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Aliases for MIR4688 Gene

Subcategory (RNA class) for MIR4688 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4688 Gene

  • MicroRNA 4688 2 3 5
  • Hsa-Mir-4688 3
  • Mir-4688 3

External Ids for MIR4688 Gene

Previous GeneCards Identifiers for MIR4688 Gene

  • GC11U901859

Summaries for MIR4688 Gene

Entrez Gene Summary for MIR4688 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4688 Gene

MIR4688 (MicroRNA 4688) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4688 Gene

Genomics for MIR4688 Gene

Regulatory Elements for MIR4688 Gene

Enhancers for MIR4688 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F046378 1 ENCODE 0.8 +4.1 4132 4.6 PKNOX1 ZFP64 SIN3A ARID4B ZNF48 GLIS2 ZNF263 SP3 SP5 REST ATG13 C11orf49 MDK MIR4688
GH11F046359 1.1 ENCODE 0.4 -13.9 -13851 5.4 HDGF PKNOX1 ARID4B SIN3A YY1 GLIS2 ZNF143 FOS ZNF263 REST ZNF408 ATG13 GC11P046351 MIR4688
GH11F046366 1 ENCODE 0.4 -8.9 -8926 1.3 HDGF ATF1 PKNOX1 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF143 KLF7 MIR4688 GC11P046351
GH11F046369 0.8 ENCODE 0.4 -6.8 -6835 1.0 HDGF ARID4B RAD21 GLIS2 ZNF143 EGR2 SMARCC1 SP3 MIER2 REST C11orf49 MIR4688 GC11P046351
GH11F046356 0.9 ENCODE 0.3 -19.2 -19209 2.3 HDGF CBX3 ARID4B ZNF48 ZNF335 GLIS2 ZNF143 EGR2 SP3 SP5 ENSG00000271350 ATG13 C11orf49 GC11P046351 MIR4688
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4688 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4688 Gene

Chromosome:
11
Start:
46,376,402 bp from pter
End:
46,376,484 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR4688 Gene

Genes around MIR4688 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4688 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4688 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4688 Gene

Proteins for MIR4688 Gene

Post-translational modifications for MIR4688 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4688 Gene

Domains & Families for MIR4688 Gene

Gene Families for MIR4688 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4688: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4688 Gene

Function for MIR4688 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4688 Gene

Localization for MIR4688 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4688 Gene

Pathways & Interactions for MIR4688 Gene

SuperPathways for MIR4688 Gene

No Data Available

Interacting Proteins for MIR4688 Gene

Gene Ontology (GO) - Biological Process for MIR4688 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4688 Gene

Transcripts for MIR4688 Gene

mRNA/cDNA for MIR4688 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4688 Gene

No ASD Table

Relevant External Links for MIR4688 Gene

GeneLoc Exon Structure for
MIR4688
ECgene alternative splicing isoforms for
MIR4688

Expression for MIR4688 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4688 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4688 Gene:

MIR4688
genes like me logo Genes that share expression patterns with MIR4688: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4688 Gene

Orthologs for MIR4688 Gene

Evolution for MIR4688 Gene

ENSEMBL:
Gene Tree for MIR4688 (if available)
TreeFam:
Gene Tree for MIR4688 (if available)

No data available for Orthologs for MIR4688 Gene

Paralogs for MIR4688 Gene

No data available for Paralogs for MIR4688 Gene

Variants for MIR4688 Gene

Sequence variations from dbSNP and Humsavar for MIR4688 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111525364 -- 46,375,306(+) TCTGC(C/T)CTCTG intron-variant, upstream-variant-2KB
rs111984305 -- 46,375,804(+) GCACC(A/G)AGGCA intron-variant, upstream-variant-2KB
rs112515619 -- 46,375,180(+) CTTGA(G/T)AGCGG intron-variant, upstream-variant-2KB
rs11557399 -- 46,375,016(+) ACCTC(G/T)AGGTC nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs115823062 -- 46,376,397(+) TGGAC(A/G/T)GTGAG nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR4688 Gene

Variant ID Type Subtype PubMed ID
nsv951610 CNV deletion 24416366
nsv825867 CNV gain 20364138
nsv554202 CNV loss 21841781
nsv554201 CNV loss 21841781
esv3626185 CNV loss 21293372
esv3626183 CNV gain 21293372

Relevant External Links for MIR4688 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4688

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4688 Gene

Disorders for MIR4688 Gene

Relevant External Links for MIR4688

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4688

No disorders were found for MIR4688 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4688 Gene

Publications for MIR4688 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4688 Gene

Sources for MIR4688 Gene

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