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Aliases for MIR4686 Gene

Subcategory (RNA class) for MIR4686 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4686 Gene

  • MicroRNA 4686 2 3 5
  • Hsa-Mir-4686 3

External Ids for MIR4686 Gene

Previous GeneCards Identifiers for MIR4686 Gene

  • GC11U901874

Summaries for MIR4686 Gene

Entrez Gene Summary for MIR4686 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4686 Gene

MIR4686 (MicroRNA 4686) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4686 Gene

Genomics for MIR4686 Gene

Regulatory Elements for MIR4686 Gene

Enhancers for MIR4686 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F002175 0.9 FANTOM5 ENCODE 0.8 +2.8 2759 0.3 CTCF BCOR ZNF202 HDGF SMARCA5 TSC22D4 ZNF407 ZNF48 POLR2A MBD1 TH IGF2 IGF2-AS MIR483 ASCL2 KRTAP5-6 MIR4686 GC11M002206
GH11F002177 0.3 FANTOM5 0.8 +4.3 4301 0.1 KLF1 TH IGF2 IGF2-AS MIR483 ASCL2 MIR4686 GC11M002206
GH11F002178 1.3 FANTOM5 Ensembl ENCODE 0.4 +5.8 5778 1.4 ZFHX2 PKNOX1 MNT FOS TCF7L2 EGR2 IGF2 TH IGF2-AS MIR483 ENSG00000236710 ASCL2 SYT8 MIR4686 GC11M002206
GH11F002180 0.5 ENCODE 0.4 +7.9 7923 0.2 ZNF341 DPF2 IGF2 TRPM5 ENSG00000199550 CD81 MIR4686 GC11M002206
GH11F002186 0.8 Ensembl ENCODE 0.4 +13.8 13762 0.8 CTCF MAX GLI4 CDC5L ZIC2 THRB RAD21 ZBTB48 SMC3 L3MBTL2 RPL36AP39 LOC390029 INS INS-IGF2 IGF2 CD81 ENSG00000199550 TH MIR4686 GC11M002206
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4686 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4686 Gene

Chromosome:
11
Start:
2,173,063 bp from pter
End:
2,173,138 bp from pter
Size:
76 bases
Orientation:
Plus strand

Genomic View for MIR4686 Gene

Genes around MIR4686 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4686 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4686 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4686 Gene

Proteins for MIR4686 Gene

Post-translational modifications for MIR4686 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4686 Gene

Domains & Families for MIR4686 Gene

Gene Families for MIR4686 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4686: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4686 Gene

Function for MIR4686 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4686 Gene

Localization for MIR4686 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4686 Gene

Pathways & Interactions for MIR4686 Gene

SuperPathways for MIR4686 Gene

No Data Available

Interacting Proteins for MIR4686 Gene

Gene Ontology (GO) - Biological Process for MIR4686 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4686 Gene

Transcripts for MIR4686 Gene

mRNA/cDNA for MIR4686 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4686 Gene

No ASD Table

Relevant External Links for MIR4686 Gene

GeneLoc Exon Structure for
MIR4686
ECgene alternative splicing isoforms for
MIR4686

Expression for MIR4686 Gene

mRNA expression in normal human tissues for MIR4686 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4686 Gene:

MIR4686
genes like me logo Genes that share expression patterns with MIR4686: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4686 Gene

Orthologs for MIR4686 Gene

Evolution for MIR4686 Gene

ENSEMBL:
Gene Tree for MIR4686 (if available)
TreeFam:
Gene Tree for MIR4686 (if available)

No data available for Orthologs for MIR4686 Gene

Paralogs for MIR4686 Gene

No data available for Paralogs for MIR4686 Gene

Variants for MIR4686 Gene

Sequence variations from dbSNP and Humsavar for MIR4686 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs74555599 Benign 2,171,771(-) CCGAC(A/G/T)CCACC upstream-variant-2KB, reference, missense
rs10734659 -- 2,172,281(+) GTCTC(A/G)TAGAC upstream-variant-2KB, utr-variant-5-prime
rs10743149 -- 2,172,945(+) GAGCC(C/T)GCCTT upstream-variant-2KB, utr-variant-5-prime
rs10770140 -- 2,172,367(+) CGCCC(C/T)GTGGG upstream-variant-2KB, utr-variant-5-prime
rs10770141 -- 2,172,610(+) TCTTT(A/G)AAGAG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4686 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV gain 19166990
nsv469927 CNV loss 18288195
nsv553047 CNV gain 21841781
nsv553068 CNV loss 21841781
nsv553070 CNV loss 21841781
nsv553079 CNV loss 21841781
nsv951284 CNV deletion 24416366

Relevant External Links for MIR4686 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4686

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4686 Gene

Disorders for MIR4686 Gene

Relevant External Links for MIR4686

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4686

No disorders were found for MIR4686 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4686 Gene

Publications for MIR4686 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4686 Gene

Sources for MIR4686 Gene

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