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Aliases for MIR4685 Gene

Subcategory (RNA class) for MIR4685 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4685 Gene

  • MicroRNA 4685 2 3 5
  • Hsa-Mir-4685 3

External Ids for MIR4685 Gene

Previous GeneCards Identifiers for MIR4685 Gene

  • GC10U901546
  • GC10M100194

Summaries for MIR4685 Gene

Entrez Gene Summary for MIR4685 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4685 Gene

MIR4685 (MicroRNA 4685) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4685 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4685 Gene

Genomics for MIR4685 Gene

Regulatory Elements for MIR4685 Gene

Enhancers for MIR4685 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H098445 1 ENCODE 0.4 -14.8 -14832 2 ATF1 MLX SIN3A ZNF2 GTF3C2 GLIS2 ELK1 ZNF143 ZNF207 KLF7 ENSG00000230928 PYROXD2 R3HCC1L MMS19 LOXL4 HPS1 LOC101927278 MIR4685
GH10H098425 0.6 ENCODE 0.4 +5.5 5462 0 CTCF ZNF654 TRIM22 ELF1 REST RAD21 ZNF143 SMC3 ZNF785 MIR4685 PYROXD2
GH10H098423 0.5 ENCODE 0.4 +7.5 7542 0 CTCF ZNF687 RAD21 TEAD3 PYROXD2 MIR4685
GH10H098444 0.4 ENCODE 0.4 -13.2 -13225 0 IKZF1 SPI1 LOC101927278 MIR4685
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4685 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4685 Gene

Chromosome:
10
Start:
98,431,292 bp from pter
End:
98,431,360 bp from pter
Size:
69 bases
Orientation:
Minus strand

Genomic View for MIR4685 Gene

Genes around MIR4685 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4685 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4685 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4685 Gene

ORGUL Member Location for MIR4685 Gene

ORGUL Member Location for MIR4685 gene

Proteins for MIR4685 Gene

Post-translational modifications for MIR4685 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4685 Gene

Domains & Families for MIR4685 Gene

Gene Families for MIR4685 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4685: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4685 Gene

Function for MIR4685 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4685
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4685 Gene

Localization for MIR4685 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4685 Gene

Pathways & Interactions for MIR4685 Gene

SuperPathways for MIR4685 Gene

No Data Available

Interacting Proteins for MIR4685 Gene

Gene Ontology (GO) - Biological Process for MIR4685 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4685 Gene

Drugs & Compounds for MIR4685 Gene

No Compound Related Data Available

Transcripts for MIR4685 Gene

mRNA/cDNA for MIR4685 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4685
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4685 Gene

No ASD Table

Relevant External Links for MIR4685 Gene

GeneLoc Exon Structure for
MIR4685
ECgene alternative splicing isoforms for
MIR4685

Expression for MIR4685 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4685 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4685 Gene:

MIR4685
genes like me logo Genes that share expression patterns with MIR4685: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4685 Gene

Orthologs for MIR4685 Gene

Evolution for MIR4685 Gene

ENSEMBL:
Gene Tree for MIR4685 (if available)
TreeFam:
Gene Tree for MIR4685 (if available)

No data available for Orthologs for MIR4685 Gene

Paralogs for MIR4685 Gene

No data available for Paralogs for MIR4685 Gene

Variants for MIR4685 Gene

Sequence variations from dbSNP and Humsavar for MIR4685 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs281865079 Pathogenic 98,431,266(+) AGCTG(-/G)GGGGT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, frameshift-variant, utr-variant-5-prime
rs1801286 Uncertain significance 98,431,242(-) AGAGG(C/T)GCTGG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-5-prime
rs746626404 Uncertain significance 98,431,197(+) CTCCC(C/T)GCTCG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-5-prime
rs757374077 Uncertain significance 98,431,234(+) GTGCC(A/G)CTCCA intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-5-prime
rs113520308 Benign 98,431,202(+) CGCTC(A/G)GGGCT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4685 Gene

Variant ID Type Subtype PubMed ID
nsv515723 CNV loss 19592680
nsv524427 CNV loss 19592680
nsv831955 CNV gain 17160897

Relevant External Links for MIR4685 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4685

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4685 Gene

Disorders for MIR4685 Gene

Relevant External Links for MIR4685

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4685

No disorders were found for MIR4685 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4685 Gene

Publications for MIR4685 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4685 Gene

Sources for MIR4685 Gene

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