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Aliases for MIR4683 Gene

Subcategory (RNA class) for MIR4683 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4683 Gene

  • MicroRNA 4683 2 3
  • FZD8 4 5
  • Frizzled Class Receptor 8 5
  • Hsa-Mir-4683 3
  • FZ-8 4
  • HFZ8 4

External Ids for MIR4683 Gene

Previous GeneCards Identifiers for MIR4683 Gene

  • GC10U901539
  • GC10M035934

Summaries for MIR4683 Gene

Entrez Gene Summary for MIR4683 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4683 Gene

MIR4683 (MicroRNA 4683) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are HIV Life Cycle and Signaling by GPCR. An important paralog of this gene is FZD5.

UniProtKB/Swiss-Prot for MIR4683 Gene

  • Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4683 Gene

Genomics for MIR4683 Gene

Regulatory Elements for MIR4683 Gene

Enhancers for MIR4683 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F035683 1.2 VISTA 11.3 -43.2 -43207 3.0 PKNOX1 ZNF133 ZFP64 RARA KAT2B ZNF121 ZNF138 ZNF354C CREM MIXL1 FZD8 ENSG00000271335 MIR4683 RPL7P37 LOC105376494
GH10F035668 0.6 ENCODE 11.7 -27.3 -27257 1.1 OSR2 ZNF121 SUZ12 MAX REST MNT WT1 FZD8 MIR4683 LOC105376494 RPL7P37
GH10F035593 0.6 ENCODE 11 +47.7 47652 1.5 CTCF POLR2A SMARCA4 ZNF547 TEAD4 KDM1A TBX21 FZD8 MIR4683 GJD4 GC10P035401
GH10F035692 0.4 ENCODE 11.3 -49.9 -49860 0.2 POU5F1 FZD8 MIR4683 RPL7P37 LOC105376494
GH10F035691 0.4 ENCODE 11.3 -49.5 -49484 0.5 POU5F1 FZD8 MIR4683 RPL7P37 LOC105376494
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4683 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4683 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000353579 478 5601 PKNOX1 FEZF1 ZNF2 YY1 ZNF121 GLIS2 KLF7 ZNF202 ZNF263 SP3

Genomic Location for MIR4683 Gene

Chromosome:
10
Start:
35,638,249 bp from pter
End:
35,642,278 bp from pter
Size:
4,030 bases
Orientation:
Minus strand

Genomic View for MIR4683 Gene

Genes around MIR4683 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4683 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4683 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4683 Gene

Proteins for MIR4683 Gene

  • Protein details for MIR4683 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H461-FZD8_HUMAN
    Recommended name:
    Frizzled-8
    Protein Accession:
    Q9H461

    Protein attributes for MIR4683 Gene

    Size:
    694 amino acids
    Molecular mass:
    73300 Da
    Quaternary structure:
    • Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts with GPOC, RSPO1 and RSPO3 (By similarity).
    • Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts with GPOC, RSPO1 and RSPO3 (By similarity).

neXtProt entry for MIR4683 Gene

Post-translational modifications for MIR4683 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Glycosylation at Asn 49, Asn 152, and Asn 475
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4683 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR4683 Gene

Domains & Families for MIR4683 Gene

Gene Families for MIR4683 Gene

Protein Domains for MIR4683 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H461

UniProtKB/Swiss-Prot:

FZD8_HUMAN :
  • The PDZ-binding motif mediates interaction with GOPC.
  • Belongs to the G-protein coupled receptor Fz/Smo family.
Domain:
  • The PDZ-binding motif mediates interaction with GOPC.
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.
genes like me logo Genes that share domains with MIR4683: view

No data available for Suggested Antigen Peptide Sequences for MIR4683 Gene

Function for MIR4683 Gene

Molecular function for MIR4683 Gene

UniProtKB/Swiss-Prot Function:
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Gene Ontology (GO) - Molecular Function for MIR4683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005102 receptor binding IEA --
GO:0017147 Wnt-protein binding IEA --
genes like me logo Genes that share ontologies with MIR4683: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4683 Gene

Localization for MIR4683 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4683 Gene

Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MIR4683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS --
GO:1990851 Wnt-Frizzled-LRP5/6 complex IEA --
genes like me logo Genes that share ontologies with MIR4683: view

No data available for Subcellular locations from COMPARTMENTS for MIR4683 Gene

Pathways & Interactions for MIR4683 Gene

genes like me logo Genes that share pathways with MIR4683: view

Gene Ontology (GO) - Biological Process for MIR4683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MIR4683: view

No data available for SIGNOR curated interactions for MIR4683 Gene

Transcripts for MIR4683 Gene

mRNA/cDNA for MIR4683 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4683 Gene

No ASD Table

Relevant External Links for MIR4683 Gene

GeneLoc Exon Structure for
MIR4683
ECgene alternative splicing isoforms for
MIR4683

Expression for MIR4683 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4683 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4683 Gene:

MIR4683

mRNA Expression by UniProt/SwissProt for MIR4683 Gene:

Q9H461-FZD8_HUMAN
Tissue specificity: Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
genes like me logo Genes that share expression patterns with MIR4683: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4683 Gene

Orthologs for MIR4683 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4683 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FZD8 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FZD8 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd8 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FZD8 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD8 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FZD8 35
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FZD8 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fzd8a 35
  • 84 (a)
OneToMany
fzd8b 35
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fz2 35
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for MIR4683 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4683 Gene

ENSEMBL:
Gene Tree for MIR4683 (if available)
TreeFam:
Gene Tree for MIR4683 (if available)

Paralogs for MIR4683 Gene

Paralogs for MIR4683 Gene

genes like me logo Genes that share paralogs with MIR4683: view

Variants for MIR4683 Gene

Sequence variations from dbSNP and Humsavar for MIR4683 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs111812311 -- 35,641,682(+) GCAGG(A/C)GCGCG upstream-variant-2KB
rs113619063 -- 35,642,015(+) TTGGG(C/G)ACCCG upstream-variant-2KB
rs12255343 -- 35,642,541(+) TGCGT(C/T)GGAGG upstream-variant-2KB
rs139457239 -- 35,642,064(+) TCCTT(-/CGTC)CGTCC upstream-variant-2KB
rs139744259 -- 35,640,680(+) ACGCG(A/G)TTGTA downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR4683 Gene

Variant ID Type Subtype PubMed ID
nsv825341 CNV gain 20364138
nsv825340 CNV gain 20364138
nsv825337 CNV gain 20364138
nsv550416 CNV gain 21841781
nsv550415 CNV loss 21841781
nsv550413 CNV loss 21841781
nsv521143 CNV loss 19592680
nsv466871 CNV loss 19166990
esv22469 CNV loss 19812545
dgv144n67 CNV gain 20364138
dgv1036n54 CNV loss 21841781
dgv1035n54 CNV loss 21841781
dgv1034n54 CNV loss 21841781

Relevant External Links for MIR4683 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4683

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4683 Gene

Disorders for MIR4683 Gene

Relevant External Links for MIR4683

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4683

No disorders were found for MIR4683 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4683 Gene

Publications for MIR4683 Gene

  1. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PMID: 22575959) Hao H.X. … Cong F. (Nature 2012) 4 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  4. Solution structure of GOPC PDZ domain and its interaction with the C- terminal motif of neuroligin. (PMID: 16882988) Li X. … Shi Y. (Protein Sci. 2006) 4 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64

Products for MIR4683 Gene

Sources for MIR4683 Gene

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