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Aliases for MIR4681 Gene

Subcategory (RNA class) for MIR4681 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4681 Gene

  • MicroRNA 4681 2 3 5
  • Hsa-Mir-4681 3

External Ids for MIR4681 Gene

Previous GeneCards Identifiers for MIR4681 Gene

  • GC10U901547
  • GC10P121139

Summaries for MIR4681 Gene

Entrez Gene Summary for MIR4681 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4681 Gene

MIR4681 (MicroRNA 4681) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4681 Gene

Genomics for MIR4681 Gene

Regulatory Elements for MIR4681 Gene

Enhancers for MIR4681 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G119377 1.3 Ensembl ENCODE dbSUPER 0.7 +0.7 663 1.4 ATF1 ZIC2 ZFHX2 GATA3 POLR2A NFYB SCRT2 EZH2 EGR2 SCRT1 EIF3A MIR4681 GC10P119418
GH10G119374 1.1 Ensembl ENCODE dbSUPER 0.7 -2.5 -2464 2.1 KLF1 ZNF10 KLF17 ZNF623 ZIC2 SMARCA4 POLR2A FOXP2 KDM1A WT1 RGS10 MIR4681 LOC105378511
GH10G119368 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -6.7 -6683 5.7 CTCF ZIC2 RAD21 ZKSCAN1 ZFHX2 GATA2 POLR2A EED SCRT2 FOS GRK5 PRDX3 MIR4681 LOC105378511
GH10G119360 1.4 Ensembl ENCODE dbSUPER 0.4 -14.5 -14546 6.5 ELF3 HDGF PKNOX1 RAD21 RARA YY1 EGR1 MIXL1 EGR2 ZNF263 GRK5 MIR4681 LOC105378511
GH10G119394 1.3 Ensembl ENCODE dbSUPER 0.4 +17.7 17695 3.3 FOXA2 ZSCAN4 RAD21 ZNF335 EGR1 SCRT2 EGR2 REST TBX21 NR2F2 GRK5 MIR4681 GC10P119418
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4681 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4681 Gene

Chromosome:
10
Start:
119,377,972 bp from pter
End:
119,378,043 bp from pter
Size:
72 bases
Orientation:
Plus strand

Genomic View for MIR4681 Gene

Genes around MIR4681 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4681 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4681 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4681 Gene

Proteins for MIR4681 Gene

Post-translational modifications for MIR4681 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4681 Gene

Domains & Families for MIR4681 Gene

Gene Families for MIR4681 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4681: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4681 Gene

Function for MIR4681 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4681 Gene

Localization for MIR4681 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4681 Gene

Pathways & Interactions for MIR4681 Gene

SuperPathways for MIR4681 Gene

No Data Available

Interacting Proteins for MIR4681 Gene

Gene Ontology (GO) - Biological Process for MIR4681 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4681 Gene

Drugs & Compounds for MIR4681 Gene

No Compound Related Data Available

Transcripts for MIR4681 Gene

mRNA/cDNA for MIR4681 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4681 Gene

No ASD Table

Relevant External Links for MIR4681 Gene

GeneLoc Exon Structure for
MIR4681
ECgene alternative splicing isoforms for
MIR4681

Expression for MIR4681 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4681 Gene:

MIR4681
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4681 Gene

Orthologs for MIR4681 Gene

Evolution for MIR4681 Gene

ENSEMBL:
Gene Tree for MIR4681 (if available)
TreeFam:
Gene Tree for MIR4681 (if available)

No data available for Orthologs for MIR4681 Gene

Paralogs for MIR4681 Gene

No data available for Paralogs for MIR4681 Gene

Variants for MIR4681 Gene

Sequence variations from dbSNP and Humsavar for MIR4681 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000226858 -- 119,378,480(+) GGGCG(A/G)ATTCC intron-variant, downstream-variant-500B
rs1001743091 -- 119,378,028(+) GCTGC(A/G)GACCT intron-variant, nc-transcript-variant
rs1003175444 -- 119,376,652(+) CTCCA(C/T)CTCCC intron-variant, upstream-variant-2KB
rs1003731203 -- 119,376,375(+) ACATA(C/T)CCCCA intron-variant, upstream-variant-2KB
rs1004536843 -- 119,377,444(+) ATGAT(A/T)TTGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4681 Gene

Variant ID Type Subtype PubMed ID
nsv832007 CNV gain 17160897

Relevant External Links for MIR4681 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4681

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4681 Gene

Disorders for MIR4681 Gene

Relevant External Links for MIR4681

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4681

No disorders were found for MIR4681 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4681 Gene

Publications for MIR4681 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4681 Gene

Sources for MIR4681 Gene

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