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Aliases for MIR4680 Gene

Subcategory (RNA class) for MIR4680 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4680 Gene

  • MicroRNA 4680 2 3 5
  • Hsa-Mir-4680 3

External Ids for MIR4680 Gene

Previous GeneCards Identifiers for MIR4680 Gene

  • GC10U901549
  • GC10P112660

Summaries for MIR4680 Gene

Entrez Gene Summary for MIR4680 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4680 Gene

MIR4680 (MicroRNA 4680) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Interferon type I signaling pathways.

Additional gene information for MIR4680 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4680 Gene

Genomics for MIR4680 Gene

GeneHancer (GH) Regulatory Elements for MIR4680 Gene

Promoters and enhancers for MIR4680 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I110895 Enhancer 0.6 dbSUPER 550.8 -1.5 -1539 2.3 ZNF146 FOXA2 RXRA MAX RAD21 YY1 JUND HNF4G HNF4A PRDM1 MIR4680 PDCD4 ENSG00000232470 SHOC2 ADRA2A ENSG00000270589 PDCD4-AS1 GC10P110732
GH10I110893 Enhancer 0.8 ENCODE dbSUPER 0.8 -4.3 -4322 0.2 CTCF ZNF654 RB1 ZNF143 SMC3 CEBPB REST RAD21 ENSG00000232470 PDCD4 MIR4680 PDCD4-AS1 GC10P110732
GH10I110901 Enhancer 0.8 ENCODE 0.8 +4.7 4732 2.1 ARNT ZNF133 BATF IRF4 ZNF335 EGR1 RCOR1 ATF7 FOS BCLAF1 ENSG00000232470 PDCD4 ENSG00000270589 GC10M110900 MIR4680 BBIP1 GC10P110732
GH10I110883 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -14.0 -14042 0.8 MEIS2 HDAC2 REST MNT MYC RUNX3 CREM ZNF592 BBIP1 SHOC2 MIR4680 PDCD4-AS1 PDCD4 GC10P110732
GH10I110884 Enhancer 0.7 dbSUPER 0.4 -12.2 -12184 2.3 HDAC1 MEIS2 PKNOX1 FOXA2 TCF12 GATA3 BRD9 NCOR1 GATAD2A SMARCE1 SHOC2 BBIP1 ENSG00000270589 ADRA2A MIR4680 PDCD4-AS1 PDCD4 GC10P110732
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4680 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4680 Gene

Genomic Locations for MIR4680 Gene
chr10:110,898,090-110,898,155
(GRCh38/hg38)
Size:
66 bases
Orientation:
Plus strand
chr10:112,657,843-112,657,916
(GRCh37/hg19)

Genomic View for MIR4680 Gene

Genes around MIR4680 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4680 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4680 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4680 Gene

Proteins for MIR4680 Gene

Post-translational modifications for MIR4680 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4680 Gene

Domains & Families for MIR4680 Gene

Gene Families for MIR4680 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4680: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4680 Gene

Function for MIR4680 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4680 Gene

Localization for MIR4680 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4680 Gene

Pathways & Interactions for MIR4680 Gene

genes like me logo Genes that share pathways with MIR4680: view

Pathways by source for MIR4680 Gene

1 BioSystems pathway for MIR4680 Gene

Interacting Proteins for MIR4680 Gene

Gene Ontology (GO) - Biological Process for MIR4680 Gene

None

No data available for SIGNOR curated interactions for MIR4680 Gene

Drugs & Compounds for MIR4680 Gene

No Compound Related Data Available

Transcripts for MIR4680 Gene

mRNA/cDNA for MIR4680 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4680 Gene

No ASD Table

Relevant External Links for MIR4680 Gene

GeneLoc Exon Structure for
MIR4680
ECgene alternative splicing isoforms for
MIR4680

Expression for MIR4680 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4680 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4680 Gene:

MIR4680
genes like me logo Genes that share expression patterns with MIR4680: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4680 Gene

Orthologs for MIR4680 Gene

Evolution for MIR4680 Gene

ENSEMBL:
Gene Tree for MIR4680 (if available)
TreeFam:
Gene Tree for MIR4680 (if available)

No data available for Orthologs for MIR4680 Gene

Paralogs for MIR4680 Gene

No data available for Paralogs for MIR4680 Gene

Variants for MIR4680 Gene

Sequence variations from dbSNP and Humsavar for MIR4680 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1001325945 -- 110,897,938(+) C/T upstream_transcript_variant
rs1001350100 -- 110,897,233(+) G/C upstream_transcript_variant
rs1002808943 -- 110,898,187(+) G/T downstream_transcript_variant
rs1005383129 -- 110,897,889(+) G/A upstream_transcript_variant
rs1005466543 -- 110,897,669(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4680 Gene

Variant ID Type Subtype PubMed ID
nsv1035602 CNV loss 25217958
nsv1069515 CNV deletion 25765185
nsv7211 OTHER inversion 18451855
nsv831985 CNV gain+loss 17160897

Additional Variant Information for MIR4680 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4680 Gene

Disorders for MIR4680 Gene

Additional Disease Information for MIR4680

No disorders were found for MIR4680 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4680 Gene

Publications for MIR4680 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4680 Gene

Sources for MIR4680 Gene

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