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Aliases for MIR4680 Gene

Subcategory (RNA class) for MIR4680 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4680 Gene

  • MicroRNA 4680 2 3
  • PDCD4 4 5
  • Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) 5
  • Neoplastic Transformation Inhibitor Protein 4
  • Nuclear Antigen H731-Like 4
  • Protein 197/15a 4
  • Hsa-Mir-4680 3
  • H731 4

External Ids for MIR4680 Gene

Previous GeneCards Identifiers for MIR4680 Gene

  • GC10U901549
  • GC10P112660

Summaries for MIR4680 Gene

Entrez Gene Summary for MIR4680 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4680 Gene

MIR4680 (MicroRNA 4680) is an RNA Gene, and is affiliated with the miRNA class.

UniProtKB/Swiss-Prot for MIR4680 Gene

  • Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4680 Gene

Genomics for MIR4680 Gene

Regulatory Elements for MIR4680 Gene


Promoters for MIR4680 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR4680 Gene

Chromosome:
10
Start:
110,871,795 bp from pter
End:
110,900,006 bp from pter
Size:
28,212 bases
Orientation:
Plus strand

Genomic View for MIR4680 Gene

Genes around MIR4680 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4680 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4680 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4680 Gene

Proteins for MIR4680 Gene

  • Protein details for MIR4680 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53EL6-PDCD4_HUMAN
    Recommended name:
    Programmed cell death protein 4
    Protein Accession:
    Q53EL6
    Secondary Accessions:
    • B2RCV4
    • B5ME91
    • O15501
    • Q5VZS6
    • Q6PJI5
    • Q8TAR5
    • Q99834

    Protein attributes for MIR4680 Gene

    Size:
    469 amino acids
    Molecular mass:
    51735 Da
    Quaternary structure:
    • Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
    • Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
    SequenceCaution:
    • Sequence=AAB42218.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH15036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR4680 Gene

    Alternative splice isoforms for MIR4680 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4680 Gene

Post-translational modifications for MIR4680 Gene

  • Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
  • Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR4680 Gene

No data available for DME Specific Peptides for MIR4680 Gene

Domains & Families for MIR4680 Gene

Gene Families for MIR4680 Gene

Protein Domains for MIR4680 Gene

Graphical View of Domain Structure for InterPro Entry

Q53EL6

UniProtKB/Swiss-Prot:

PDCD4_HUMAN :
  • Binds EIF4A1 via both MI domains.
  • Belongs to the PDCD4 family.
Domain:
  • Binds EIF4A1 via both MI domains.
  • Contains 2 MI domains.
Family:
  • Belongs to the PDCD4 family.
genes like me logo Genes that share domains with MIR4680: view

No data available for Suggested Antigen Peptide Sequences for MIR4680 Gene

Function for MIR4680 Gene

Molecular function for MIR4680 Gene

UniProtKB/Swiss-Prot Function:
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
UniProtKB/Swiss-Prot Induction:
IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression.

Gene Ontology (GO) - Molecular Function for MIR4680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with MIR4680: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4680 Gene

Localization for MIR4680 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4680 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269 PubMed:16357133}.

Gene Ontology (GO) - Cellular Components for MIR4680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IMP --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MIR4680: view

No data available for Subcellular locations from COMPARTMENTS for MIR4680 Gene

Pathways & Interactions for MIR4680 Gene

SuperPathways for MIR4680 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS --
GO:0007569 cell aging IDA --
GO:0034393 positive regulation of smooth muscle cell apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043508 negative regulation of JUN kinase activity ISS --
genes like me logo Genes that share ontologies with MIR4680: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4680 Gene

Drugs & Compounds for MIR4680 Gene

No Compound Related Data Available

Transcripts for MIR4680 Gene

mRNA/cDNA for MIR4680 Gene

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4680 Gene

No ASD Table

Relevant External Links for MIR4680 Gene

GeneLoc Exon Structure for
MIR4680
ECgene alternative splicing isoforms for
MIR4680

Expression for MIR4680 Gene

mRNA expression in normal human tissues for MIR4680 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4680 Gene:

MIR4680

mRNA Expression by UniProt/SwissProt for MIR4680 Gene:

Q53EL6-PDCD4_HUMAN
Tissue specificity: Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
genes like me logo Genes that share expression patterns with MIR4680: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4680 Gene

Orthologs for MIR4680 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4680 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDCD4 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDCD4 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDCD4 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcd4 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PDCD4 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDCD4 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDCD4 35
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pdcd4b 35
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pdcd4 35
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2910 35
  • 40 (a)
OneToOne
Species where no ortholog for MIR4680 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4680 Gene

ENSEMBL:
Gene Tree for MIR4680 (if available)
TreeFam:
Gene Tree for MIR4680 (if available)

Paralogs for MIR4680 Gene

No data available for Paralogs for MIR4680 Gene

Variants for MIR4680 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4680 Gene

Variant ID Type Subtype PubMed ID
nsv1035602 CNV loss 25217958
nsv1069515 CNV deletion 25765185
nsv7211 OTHER inversion 18451855
nsv831985 CNV gain+loss 17160897

Relevant External Links for MIR4680 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4680 Gene

Disorders for MIR4680 Gene

Relevant External Links for MIR4680

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4680

No disorders were found for MIR4680 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4680 Gene

Publications for MIR4680 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 65
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 65

Products for MIR4680 Gene

Sources for MIR4680 Gene

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