Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4674 Gene

Subcategory (RNA class) for MIR4674 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4674 Gene

  • MicroRNA 4674 2 3 5
  • Hsa-Mir-4674 3

External Ids for MIR4674 Gene

Previous GeneCards Identifiers for MIR4674 Gene

  • GC09U901721
  • GC09M139442

Summaries for MIR4674 Gene

Entrez Gene Summary for MIR4674 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4674 Gene

MIR4674 (MicroRNA 4674) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4674 Gene

Genomics for MIR4674 Gene

Regulatory Elements for MIR4674 Gene

Enhancers for MIR4674 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G136549 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -5.6 -5584 4.5 HDGF GLIS2 GATA2 EGR1 ZNF366 SCRT2 ZNF416 FOS RELB IKZF2 SEC16A C9orf163 INPP5E TMEM203 NOTCH1 NALT1 SDCCAG3 TMEM141 MIR4674 LINC01451
GH09G136563 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 0.3 -22.3 -22284 10.7 HDGF FOXA2 MLX WRNIP1 ARID4B SIN3A YBX1 ZBTB7B SLC30A9 ZNF143 NOTCH1 SNAPC4 ANAPC2 CCDC183-AS1 SEC16A FUT7 TMEM250 NACC2 MIR4674 LINC01451
GH09G136586 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -41.9 -41885 3.5 ATF1 ETS1 TCF12 ZNF766 GLIS2 ELK1 KDM4B REST ZNF592 MBD2 NALT1 ENSG00000227512 C9orf163 LINC01451 MIR4674
GH09G136550 0.7 ENCODE dbSUPER 0.7 -3.3 -3268 0.2 GLIS2 ZBTB48 ZIC2 C9orf163 SEC16A INPP5E NALT1 MIR4674 LINC01451
GH09G136557 1.2 Ensembl ENCODE dbSUPER 0.4 -11.9 -11943 2.0 SMARCC1 ZNF687 MTA2 SREBF2 CEBPB GATAD2B DPF2 ZNF592 ZNF121 CTBP1 SEC16A NOTCH1 MIR4674 LINC01451
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4674 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4674 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243031 659 2401 CREB3L1 SIN3A FEZF1 ZNF2 ZNF766 ZNF207 ZNF143 ZNF263 SP3 JUNB

Genomic Location for MIR4674 Gene

Chromosome:
9
Start:
136,546,173 bp from pter
End:
136,546,259 bp from pter
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR4674 Gene

Genes around MIR4674 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4674 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4674 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4674 Gene

ORGUL Member Location for MIR4674 Gene

ORGUL Member Location for MIR4674 gene

Proteins for MIR4674 Gene

Post-translational modifications for MIR4674 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4674 Gene

Domains & Families for MIR4674 Gene

Gene Families for MIR4674 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4674: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4674 Gene

Function for MIR4674 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4674 Gene

Localization for MIR4674 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4674 Gene

Pathways & Interactions for MIR4674 Gene

SuperPathways for MIR4674 Gene

No Data Available

Interacting Proteins for MIR4674 Gene

Gene Ontology (GO) - Biological Process for MIR4674 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4674 Gene

Drugs & Compounds for MIR4674 Gene

No Compound Related Data Available

Transcripts for MIR4674 Gene

mRNA/cDNA for MIR4674 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4674 Gene

No ASD Table

Relevant External Links for MIR4674 Gene

GeneLoc Exon Structure for
MIR4674
ECgene alternative splicing isoforms for
MIR4674

Expression for MIR4674 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4674 Gene:

MIR4674
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4674 Gene

Orthologs for MIR4674 Gene

Evolution for MIR4674 Gene

ENSEMBL:
Gene Tree for MIR4674 (if available)
TreeFam:
Gene Tree for MIR4674 (if available)

No data available for Orthologs for MIR4674 Gene

Paralogs for MIR4674 Gene

No data available for Paralogs for MIR4674 Gene

Variants for MIR4674 Gene

Sequence variations from dbSNP and Humsavar for MIR4674 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1002164447 -- 136,546,604(+) TCGCC(G/T)CCAGA upstream-variant-2KB
rs1002659444 -- 136,546,064(+) GTCGA(C/G)GTGCG downstream-variant-500B, upstream-variant-2KB
rs1002684206 -- 136,547,284(+) ACTCT(A/G)GAAAC upstream-variant-2KB
rs1003144942 -- 136,547,091(+) CCTGG(A/T)GTAGG upstream-variant-2KB
rs1005456406 -- 136,546,118(+) GGTCC(A/C)CCCGC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4674 Gene

Variant ID Type Subtype PubMed ID
esv2759720 CNV loss 17122850
esv30005 CNV loss 17803354
nsv1161916 CNV deletion 26073780
nsv1161917 CNV deletion 26073780
nsv466673 CNV gain 19166990
nsv469918 CNV loss 18288195
nsv509334 CNV insertion 20534489
nsv615965 CNV loss 21841781
nsv615966 CNV gain 21841781
nsv615967 CNV loss 21841781
nsv6768 CNV insertion 18451855
nsv8579 CNV gain 18304495
nsv951202 CNV deletion 24416366

Relevant External Links for MIR4674 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4674

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4674 Gene

Disorders for MIR4674 Gene

Relevant External Links for MIR4674

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4674

No disorders were found for MIR4674 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4674 Gene

Publications for MIR4674 Gene

  1. MicroRNA hsa-miR-4674 in Hemolysis-Free Blood Plasma Is Associated with Distant Metastases of Prostatic Cancer. (PMID: 27265126) Knyazev E.N. … Shkurnikov M.Y. (Bull. Exp. Biol. Med. 2016) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4674 Gene

Sources for MIR4674 Gene

Content
Loading form....