Aliases for MIR4659A Gene
Subcategory (RNA class) for MIR4659A Gene
Quality Score for this RNA gene is
External Ids for MIR4659A Gene
- HGNC: 41857
- Entrez Gene: 100616348
- Ensembl: ENSG00000266038
- miRBase: hsa-mir-4659a
Previous GeneCards Identifiers for MIR4659A Gene
- GC08U901565
- GC08P006605
Summaries for MIR4659A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4659A Gene
MIR4659A (MicroRNA 4659a) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR4659A Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4659A Gene
Genomics for MIR4659A Gene
GeneHancer (GH) Regulatory Elements for MIR4659A Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08I006744 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 0.8 | +2.7 | 2675 | 7.2 | HDGF FOXA2 SMAD1 ARNT SIN3A YBX1 IRF4 ZNF766 ZNF207 ZNF143 | AGPAT5 MCPH1-AS1 ANGPT2 OR7E154P MIR4659A MIR4659B PIR35931 | |
GH08I006731 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 0.4 | -11.8 | -11762 | 3.5 | HDGF RB1 ZNF133 BATF ZNF335 TCF12 ETV6 BCLAF1 IKZF2 RUNX3 | AGPAT5 MCPH1-AS1 MIR4659A LOC100422495 | |
GH08I006735 | Enhancer | 1 | ENCODE dbSUPER | 0.4 | -8.8 | -8796 | 2.1 | HDGF HDAC1 ELF3 FOXA2 SMAD1 IRF4 CBX5 ATF7 ETV6 BCLAF1 | AGPAT5 MCPH1-AS1 MIR4659A LOC100422495 | |
GH08I006727 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 0.4 | -16.2 | -16238 | 2.7 | ZNF687 JUN JUNB EBF1 ELF1 IKZF1 NBN HNF4A IKZF2 PRDM1 | AGPAT5 MCPH1-AS1 ANGPT2 LOC100422495 MIR4659A | |
GH08I006737 | Enhancer | 0.6 | ENCODE dbSUPER | 0.4 | -7.0 | -7031 | 0.8 | MLLT1 PRDM1 ZNF592 | AGPAT5 MCPH1-AS1 MIR4659A LOC100422495 |
Regulatory Element Products
Genomic Locations for MIR4659A Gene
- chr8:6,745,164-6,745,244
- (GRCh38/hg38)
- Size:
- 81 bases
- Orientation:
- Plus strand
- chr8:6,602,685-6,602,765
- (GRCh37/hg19)
Genomic View for MIR4659A Gene
- Cytogenetic band:
-
- 8p23.1 by Ensembl
- 8p23.1 by Entrez Gene
- 8p23.1 by HGNC


RefSeq DNA sequence for MIR4659A Gene
Proteins for MIR4659A Gene
Post-translational modifications for MIR4659A Gene
Antibody Products
- Search GeneTex for Antibodies for MIR4659A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4659A
- Origene Custom Protein Services for MIR4659A
- Search GeneTex for Proteins for MIR4659A
No data available for DME Specific Peptides for MIR4659A Gene
Domains & Families for MIR4659A Gene
Gene Families for MIR4659A Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4659A Gene
Function for MIR4659A Gene
Animal Model Products
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-
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CRISPR Products
- Browse CRISPR knockouts for MIR4659A
- Applied Biological Materials CRISPR for MIR4659A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR4659A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR4659A
Clone Products
- GenScript: Custom all cDNA clones Services for MIR4659A
- VectorBuilder custom plasmid, inducible vectors for MIR4659A
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR4659A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4659A Gene
Localization for MIR4659A Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4659A Gene
Transcripts for MIR4659A Gene
mRNA/cDNA for MIR4659A Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR4659A
- Applied Biological Materials CRISPR for MIR4659A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR4659A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR4659A
Clone Products
- GenScript: Custom all cDNA clones Services for MIR4659A
- VectorBuilder custom plasmid, inducible vectors for MIR4659A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR4659A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR4659A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR4659A Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR4659A Gene:
MIR4659APrimer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4659A Gene
Orthologs for MIR4659A Gene
No data available for Orthologs for MIR4659A Gene
Paralogs for MIR4659A Gene
No data available for Paralogs for MIR4659A Gene
Variants for MIR4659A Gene
SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000667529 | -- | 6,743,449(+) | T/C | upstream_transcript_variant | |
rs1002791998 | -- | 6,744,288(+) | C/G | upstream_transcript_variant | |
rs1003193687 | -- | 6,744,890(+) | C/G | upstream_transcript_variant | |
rs1003858044 | -- | 6,745,142(+) | C/G | upstream_transcript_variant | |
rs1005177870 | -- | 6,745,249(+) | C/T | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv6876n100 | CNV | loss | 25217958 |
dgv6877n100 | CNV | gain | 25217958 |
dgv6878n100 | CNV | gain | 25217958 |
esv2422383 | CNV | duplication | 17116639 |
nsv1021684 | CNV | loss | 25217958 |
nsv1025976 | CNV | loss | 25217958 |
nsv1031577 | CNV | gain | 25217958 |
nsv465436 | CNV | gain | 19166990 |
nsv610004 | CNV | gain | 21841781 |
nsv610006 | CNV | gain | 21841781 |
nsv831220 | CNV | gain | 17160897 |
Additional Variant Information for MIR4659A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR4659A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4659A Gene
Disorders for MIR4659A Gene
Additional Disease Information for MIR4659A
No disorders were found for MIR4659A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4659A Gene
Publications for MIR4659A Gene
- miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
- Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
Products for MIR4659A Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR4659A
- VectorBuilder custom plasmid, inducible vectors for MIR4659A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR4659A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR4659A
- Search GeneTex for Proteins for MIR4659A
Sources for MIR4659A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
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- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew