Aliases for MIR4659A Gene
Subcategory (RNA class) for MIR4659A Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR4659A Gene
- HGNC: 41857
- Entrez Gene: 100616348
- Ensembl: ENSG00000266038
- miRBase: hsa-mir-4659a
Previous GeneCards Identifiers for MIR4659A Gene
- GC08U901565
- GC08P006605
Summaries for MIR4659A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4659A Gene
MIR4659A (MicroRNA 4659a) is an RNA Gene, and is affiliated with the miRNA class.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4659A Gene
Genomics for MIR4659A Gene
Regulatory Elements for MIR4659A Gene
Enhancers for MIR4659A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G006731 | 1.4 | Ensembl ENCODE dbSUPER | 0.4 | -11.8 | -11763 | 3.5 | HDGF WRNIP1 ZNF133 SIN3A ZBTB40 TCF12 GATA2 SCRT2 FOS RELB | AGPAT5 MCPH1-AS1 MIR4659A LOC100422495 |
| GH08G006735 | 1.2 | ENCODE dbSUPER | 0.4 | -8.8 | -8796 | 2.1 | HDGF FOXA2 WRNIP1 ARID4B DMAP1 ZNF48 CBX5 PPARG SMARCA4 NBN | AGPAT5 MCPH1-AS1 MIR4659A LOC100422495 |
| GH08G006727 | 1.2 | Ensembl ENCODE dbSUPER | 0.4 | -16.2 | -16239 | 2.7 | CTCF MTA2 BHLHE40 JUN JUNB ZBTB40 JUND GATA2 EED IKZF1 | AGPAT5 MCPH1-AS1 ANGPT2 LOC100422495 MIR4659A |
| GH08G006737 | 0.8 | ENCODE dbSUPER | 0.4 | -7.0 | -7031 | 0.8 | ELF3 FOXA2 WRNIP1 MLLT1 PRDM1 ZNF652 | AGPAT5 MCPH1-AS1 MIR4659A LOC100422495 |
| GH08G006724 | 0.5 | dbSUPER | 0.4 | -19.2 | -19181 | 2.0 | ZNF316 SMARCA4 EMSY MAFK SPI1 | AGPAT5 ANGPT2 LOC100422495 MIR4659A |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MIR4659A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MIR4659A Gene
- Chromosome:
- 8
- Start:
- 6,745,164 bp from pter
- End:
- 6,745,244 bp from pter
- Size:
- 81 bases
- Orientation:
- Plus strand
Genomic View for MIR4659A Gene
Genes around MIR4659A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p23.1 by Ensembl
- 8p23.1 by Entrez Gene
- 8p23.1 by HGNC
MIR4659A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR4659A Gene
Proteins for MIR4659A Gene
Post-translational modifications for MIR4659A Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR4659A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4659A
- Origene Custom Protein Services for MIR4659A
- Search GeneTex for Proteins for MIR4659A
Assay Products
No data available for DME Specific Peptides for MIR4659A Gene
Domains & Families for MIR4659A Gene
Gene Families for MIR4659A Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4659A Gene
Function for MIR4659A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Search ViGene Biosciences for MIR4659A
CRISPR Products
- Browse CRISPR knockouts for MIR4659A
miRNA Products
- Search ViGene Biosciences for MIR4659A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR4659A
Cell Line Products
- Search ViGene Biosciences for MIR4659A
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4659A Gene
Localization for MIR4659A Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4659A Gene
Transcripts for MIR4659A Gene
mRNA/cDNA for MIR4659A Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR4659A
miRNA Products
- Search ViGene Biosciences for MIR4659A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR4659A
Flow Cytometry Products
Expression for MIR4659A Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR4659A Gene:
MIR4659APrimer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4659A Gene
Orthologs for MIR4659A Gene
No data available for Orthologs for MIR4659A Gene
Paralogs for MIR4659A Gene
No data available for Paralogs for MIR4659A Gene
Variants for MIR4659A Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000667529 | -- | 6,743,449(+) | ATGCA(C/T)ACACT | intron-variant, upstream-variant-2KB | |
| rs1002791998 | -- | 6,744,288(+) | GCCAA(C/G)TTCTG | intron-variant, upstream-variant-2KB | |
| rs1003193687 | -- | 6,744,890(+) | TCTCC(C/G)TTCCT | intron-variant, downstream-variant-500B, upstream-variant-2KB | |
| rs1003858044 | -- | 6,745,142(+) | AGTCT(C/G)TTGAC | intron-variant, downstream-variant-500B, upstream-variant-2KB | |
| rs1005177870 | -- | 6,745,249(+) | CTAAG(C/T)TCTTG | intron-variant, downstream-variant-500B, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv6876n100 | CNV | loss | 25217958 |
| dgv6877n100 | CNV | gain | 25217958 |
| dgv6878n100 | CNV | gain | 25217958 |
| esv2422383 | CNV | duplication | 17116639 |
| nsv1021684 | CNV | loss | 25217958 |
| nsv1025976 | CNV | loss | 25217958 |
| nsv1031577 | CNV | gain | 25217958 |
| nsv465436 | CNV | gain | 19166990 |
| nsv610004 | CNV | gain | 21841781 |
| nsv610006 | CNV | gain | 21841781 |
| nsv831220 | CNV | gain | 17160897 |
Relevant External Links for MIR4659A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR4659A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4659A Gene
Disorders for MIR4659A Gene
Relevant External Links for MIR4659A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MIR4659A
No disorders were found for MIR4659A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4659A Gene
Publications for MIR4659A Gene
- miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
- Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
Products for MIR4659A Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
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- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4659A
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- Browse CRISPR knockouts for MIR4659A
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- Browse OriGene miRNA Products For MIR4659A
- GenScript: Custom all cDNA clones Services for MIR4659A
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- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR4659A
- VectorBuilder custom plasmid, inducible vectors for MIR4659A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR4659A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MIR4659A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer