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MIR4659A Gene(RNA Gene)

MicroRNA 4659a

GCID:
GC08P006745
GIFtS:
13
Genes Participants
UDN Logo

Aliases for MIR4659A Gene

Subcategory (RNA class) for MIR4659A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4659A Gene

  • MicroRNA 4659a 2 3 5
  • Hsa-Mir-4659a 3
  • Mir-4659a 3

External Ids for MIR4659A Gene

Previous GeneCards Identifiers for MIR4659A Gene

  • GC08U901565
  • GC08P006605

Summaries for MIR4659A Gene

Entrez Gene Summary for MIR4659A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4659A Gene

MIR4659A (MicroRNA 4659a) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4659A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4659A Gene

Genomics for MIR4659A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR4659A Gene

Promoters and enhancers for MIR4659A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08I006744 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.8 +2.7 2675 7.2 HDGF FOXA2 SMAD1 ARNT SIN3A YBX1 IRF4 ZNF766 ZNF207 ZNF143 AGPAT5 MCPH1-AS1 ANGPT2 OR7E154P MIR4659A MIR4659B PIR35931
GH08I006731 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 -11.8 -11762 3.5 HDGF RB1 ZNF133 BATF ZNF335 TCF12 ETV6 BCLAF1 IKZF2 RUNX3 AGPAT5 MCPH1-AS1 MIR4659A LOC100422495
GH08I006735 Enhancer 1 ENCODE dbSUPER 0.4 -8.8 -8796 2.1 HDGF HDAC1 ELF3 FOXA2 SMAD1 IRF4 CBX5 ATF7 ETV6 BCLAF1 AGPAT5 MCPH1-AS1 MIR4659A LOC100422495
GH08I006727 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -16.2 -16238 2.7 ZNF687 JUN JUNB EBF1 ELF1 IKZF1 NBN HNF4A IKZF2 PRDM1 AGPAT5 MCPH1-AS1 ANGPT2 LOC100422495 MIR4659A
GH08I006737 Enhancer 0.6 ENCODE dbSUPER 0.4 -7.0 -7031 0.8 MLLT1 PRDM1 ZNF592 AGPAT5 MCPH1-AS1 MIR4659A LOC100422495
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4659A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4659A Gene

Genomic Locations for MIR4659A Gene
chr8:6,745,164-6,745,244
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr8:6,602,685-6,602,765
(GRCh37/hg19)

Genomic View for MIR4659A Gene

Genes around MIR4659A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4659A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4659A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR4659A Gene

Proteins for MIR4659A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR4659A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4659A Gene

Domains & Families for MIR4659A Gene

Gene Families for MIR4659A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4659A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4659A Gene

Function for MIR4659A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4659A Gene

Localization for MIR4659A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4659A Gene

Pathways & Interactions for MIR4659A Gene

SuperPathways for MIR4659A Gene

PathCards logo More details on SuperPathways for MIR4659A
No Data Available

Interacting Proteins for MIR4659A Gene

Gene Ontology (GO) - Biological Process for MIR4659A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4659A Gene

Drugs & Compounds for MIR4659A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR4659A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR4659A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4659A Gene

No ASD Table

Relevant External Links for MIR4659A Gene

GeneLoc Exon Structure for
MIR4659A
ECgene alternative splicing isoforms for
MIR4659A

Expression for MIR4659A Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4659A Gene

mRNA expression in normal human tissues for MIR4659A Gene
mRNA expression by GTEx for MIR4659A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4659A Gene:

MIR4659A
genes like me logo Genes that share expression patterns with MIR4659A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4659A Gene

Orthologs for MIR4659A Gene

Evolution for MIR4659A Gene

ENSEMBL:
Gene Tree for MIR4659A (if available)
TreeFam:
Gene Tree for MIR4659A (if available)

No data available for Orthologs for MIR4659A Gene

Paralogs for MIR4659A Gene

No data available for Paralogs for MIR4659A Gene

Variants for MIR4659A Gene

Sequence variations from dbSNP and Humsavar for MIR4659A Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000667529 -- 6,743,449(+) T/C upstream_transcript_variant
rs1002791998 -- 6,744,288(+) C/G upstream_transcript_variant
rs1003193687 -- 6,744,890(+) C/G upstream_transcript_variant
rs1003858044 -- 6,745,142(+) C/G upstream_transcript_variant
rs1005177870 -- 6,745,249(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4659A Gene

Variant ID Type Subtype PubMed ID
dgv6876n100 CNV loss 25217958
dgv6877n100 CNV gain 25217958
dgv6878n100 CNV gain 25217958
esv2422383 CNV duplication 17116639
nsv1021684 CNV loss 25217958
nsv1025976 CNV loss 25217958
nsv1031577 CNV gain 25217958
nsv465436 CNV gain 19166990
nsv610004 CNV gain 21841781
nsv610006 CNV gain 21841781
nsv831220 CNV gain 17160897

Additional Variant Information for MIR4659A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4659A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4659A Gene

Disorders for MIR4659A Gene

Additional Disease Information for MIR4659A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR4659A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4659A Gene

Publications for MIR4659A Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4659A Gene

Sources for MIR4659A Gene

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