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Aliases for MIR4659A Gene

Subcategory (RNA class) for MIR4659A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4659A Gene

  • MicroRNA 4659a 2 3 5
  • Hsa-Mir-4659a 3
  • Mir-4659a 3

External Ids for MIR4659A Gene

Previous GeneCards Identifiers for MIR4659A Gene

  • GC08U901565
  • GC08P006605

Summaries for MIR4659A Gene

Entrez Gene Summary for MIR4659A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4659A Gene

MIR4659A (MicroRNA 4659a) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4659A Gene

Genomics for MIR4659A Gene

Regulatory Elements for MIR4659A Gene

Enhancers for MIR4659A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G006731 1.4 Ensembl ENCODE dbSUPER 0.4 -11.8 -11763 3.5 HDGF WRNIP1 ZNF133 SIN3A ZBTB40 TCF12 GATA2 SCRT2 FOS RELB AGPAT5 MCPH1-AS1 MIR4659A LOC100422495
GH08G006735 1.2 ENCODE dbSUPER 0.4 -8.8 -8796 2.1 HDGF FOXA2 WRNIP1 ARID4B DMAP1 ZNF48 CBX5 PPARG SMARCA4 NBN AGPAT5 MCPH1-AS1 MIR4659A LOC100422495
GH08G006727 1.2 Ensembl ENCODE dbSUPER 0.4 -16.2 -16239 2.7 CTCF MTA2 BHLHE40 JUN JUNB ZBTB40 JUND GATA2 EED IKZF1 AGPAT5 MCPH1-AS1 ANGPT2 LOC100422495 MIR4659A
GH08G006737 0.8 ENCODE dbSUPER 0.4 -7.0 -7031 0.8 ELF3 FOXA2 WRNIP1 MLLT1 PRDM1 ZNF652 AGPAT5 MCPH1-AS1 MIR4659A LOC100422495
GH08G006724 0.5 dbSUPER 0.4 -19.2 -19181 2.0 ZNF316 SMARCA4 EMSY MAFK SPI1 AGPAT5 ANGPT2 LOC100422495 MIR4659A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4659A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4659A Gene

Chromosome:
8
Start:
6,745,164 bp from pter
End:
6,745,244 bp from pter
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR4659A Gene

Genes around MIR4659A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4659A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4659A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4659A Gene

Proteins for MIR4659A Gene

Post-translational modifications for MIR4659A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4659A Gene

Domains & Families for MIR4659A Gene

Gene Families for MIR4659A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4659A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4659A Gene

Function for MIR4659A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4659A Gene

Localization for MIR4659A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4659A Gene

Pathways & Interactions for MIR4659A Gene

SuperPathways for MIR4659A Gene

No Data Available

Interacting Proteins for MIR4659A Gene

Gene Ontology (GO) - Biological Process for MIR4659A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4659A Gene

Transcripts for MIR4659A Gene

mRNA/cDNA for MIR4659A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4659A Gene

No ASD Table

Relevant External Links for MIR4659A Gene

GeneLoc Exon Structure for
MIR4659A
ECgene alternative splicing isoforms for
MIR4659A

Expression for MIR4659A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4659A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4659A Gene:

MIR4659A
genes like me logo Genes that share expression patterns with MIR4659A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4659A Gene

Orthologs for MIR4659A Gene

Evolution for MIR4659A Gene

ENSEMBL:
Gene Tree for MIR4659A (if available)
TreeFam:
Gene Tree for MIR4659A (if available)

No data available for Orthologs for MIR4659A Gene

Paralogs for MIR4659A Gene

No data available for Paralogs for MIR4659A Gene

Variants for MIR4659A Gene

Sequence variations from dbSNP and Humsavar for MIR4659A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000667529 -- 6,743,449(+) ATGCA(C/T)ACACT intron-variant, upstream-variant-2KB
rs1002791998 -- 6,744,288(+) GCCAA(C/G)TTCTG intron-variant, upstream-variant-2KB
rs1003193687 -- 6,744,890(+) TCTCC(C/G)TTCCT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003858044 -- 6,745,142(+) AGTCT(C/G)TTGAC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1005177870 -- 6,745,249(+) CTAAG(C/T)TCTTG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4659A Gene

Variant ID Type Subtype PubMed ID
dgv6876n100 CNV loss 25217958
dgv6877n100 CNV gain 25217958
dgv6878n100 CNV gain 25217958
esv2422383 CNV duplication 17116639
nsv1021684 CNV loss 25217958
nsv1025976 CNV loss 25217958
nsv1031577 CNV gain 25217958
nsv465436 CNV gain 19166990
nsv610004 CNV gain 21841781
nsv610006 CNV gain 21841781
nsv831220 CNV gain 17160897

Relevant External Links for MIR4659A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4659A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4659A Gene

Disorders for MIR4659A Gene

Relevant External Links for MIR4659A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4659A

No disorders were found for MIR4659A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4659A Gene

Publications for MIR4659A Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4659A Gene

Sources for MIR4659A Gene

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