MIR4659A Gene RNA gene GIFtS : 14 GCID: GC08 P006605
MicroRNA 4659a
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Aliasesfor MIR4659A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section GeneCards Plus Subcategory (RNA class): miRNAQuality score for this RNA gene is 3 Aliases MicroRNA 4659a 1 2 mir-4659a9
Export aliases for MIR4659A gene to outside databases Previous GC identifer: GC08U901565
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Summariesfor MIR4659A gene (According to Entrez Gene ,
GeneCards ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Plus Entrez Gene summary for MIR4659A Gene: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation ofgene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs aretranscribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that canbe either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzymeto produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by thecytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. Themature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs throughimperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization ofthe target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009) GeneCards Summary for MIR4659A Gene: MIR4659A (microRNA 4659a) is an RNA gene, and is affiliated with the miRNA class.
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Genomic Viewsfor MIR4659A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 75) ,
Regulatory elements and Epigenetics data according to
QIAGEN , and/or
SwitchGear Genomics )About This Section GeneCards Plus Regulatory elements: Search for regulatory transcription factor binding sites for MIR4659A Other transcription factors Search Chromatin IP Primers for MIR4659A Epigenetics: DNA Methylation CpG Assay Predesigned for Pyrosequencing in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Ensembl cytogenetic band: 8p23.1 HGNC chromosome: 8 MIR4659A Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08P006605: view genomic region miRBase )
(about GC identifiers )
Start: 6,602,685 bp from pter End:
6,602,765 bp from pter
Size: 81 bases Orientation:
plus strand
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Proteinsfor MIR4659A gene
(According to
1 UniProtKB ,
HORDE ,
2 neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec ,
Cloud-Clone Corp. ,
eBioscience , and/or
antibodies-online ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences ,
Cloud-Clone Corp. ,
eBioscience , and/or
antibodies-online ,
Antibodies by
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam ,
Cloud-Clone Corp ,
antibodies-online ,
and/or others.)
About This Section GeneCards Plus UniProtKB: --
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Domains /for MIR4659A gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section GeneCards Plus HGNC Gene Families: MIR: ncRNAs / Micro RNAs
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Functionfor MIR4659A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
genOway ,
QIAGEN
and/or HOMER ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
Gene Editing from DNA2.0 ,
Clones from OriGene ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs
and/or Addgene ,
Cell Lines from GenScript ,
ESI BIO ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Flow cytometry from eBioscience ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus
Animal Models: Inhib. RNA Browse OriGene RNAi Predesigned siRNA for gene silencing in human mouse rat
Cell Line GenScript Custom overexpressing Cell Line Services for MIR4659A Browse ESI BIO Cell Lines and PureStem Progenitors for MIR4659A In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR4659A
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Localizationfor MIR4659A gene
(According to UniProtKB , COMPARTMENTS Subcellular localization database ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus
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Pathways & Interactionsfor MIR4659A gene
(SuperPaths according to PathCards ,
Pathways according to
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
QIAGEN ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene) .
About This Section GeneCards Plus
Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR4659A Interactions: Search GeneGlobe Interaction Network for MIR4659A
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Drugs & Compoundsfor MIR4659A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience ,
ApexBio ,
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB )
About This Section GeneCards Plus
Browse compounds at ApexBio Browse Tocris compounds for MIR4659A
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Transcriptsfor MIR4659A gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
OriGene ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
and/or Addgene ,
Primers from
OriGene , and/or
QIAGEN ,
Flow cytometry from eBioscience
)About This Section GeneCards Plus 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000580269(miRNA) Inhib. RNA Browse OriGene RNAi Predesigned siRNA for gene silencing in human mouse rat
GeneLoc Exon Structure
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Expression for MIR4659A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MaxQB ,
plus additional links to
SOURCE , and/or
BioGPS , and/or
UniProtKB ,QIAGEN ,
Primers from
OriGene , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GeneCards Plus
Expression evidence for MIR4659A:none See probesets specificity/sensitivity at GeneAnnot CGAP TAG: --
MIR4659A Protein expression data from MOPED1 2 3 : Custom PCR Arrays for MIR4659A Primer Browse OriGene qPCR Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat MIR4659A QuantiTect SYBR Green Assays in human mouse rat QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR4659A
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Orthologsfor MIR4659A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section GeneCards Plus
ENSEMBL Gene Tree for MIR4659A (if available)TreeFam Gene Tree for MIR4659A (if available)
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Paralogsfor MIR4659A gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section GeneCards Plus
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Genomic Variantsfor MIR4659A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) , the Human Cytochrome P450 Allele
Nomenclature Database , and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN )
About This Section GeneCards Plus Structural Variations Database of Genomic Variants (DGV) 3 variations for MIR4659A : About this table Site Specific Mutation Identification with PCR Assays
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Disorders
/ Diseasesfor MIR4659A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section GeneCards Plus
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Publicationsfor MIR4659A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section GeneCards Plus PubMed articles for MIR4659A gene integrated from 10 sources :(articles sorted by number of sources associating them with MIR4659A) Utopia : connect your pdf to the dynamic
Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PubMed id 21199797) 1 (Cancer Res. 2011) miRBase: microRNA sequences, targets and gene nomenclature. (PubMed id 16381832) 1 (Nucleic Acids Res. 2006)
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External Searches for MIR4659A gene (in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section GeneCards Plus
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Genome Databases showing MIR4659A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section GeneCards Plus
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Other Databases showing MIR4659A gene
(According to HUGE )
About This Section GeneCards Plus --
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Specialized Databases showing MIR4659A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , UniProtKB/TrEMBL , and/or others, e.g. Wikipedia and GeneReviews , via UniProtKB/Swiss-Prot )About This Section GeneCards Plus
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About This Section GeneCards Plus Patent Information for MIR4659A gene: MIR4659A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MIR4659A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , eBioscience , antibodies-online , and/or others, Gene Editing from DNA2.0 . Clones from OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Addgene , Cell lines from GenScript , and ESI BIO , Flow cytometery from eBioscience , PCR Arrays from QIAGEN , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , Enzo Life Sciences , and/or
ApexBio , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from genOway )About This Section GeneCards Plus
Block miRNA regulation of human, mouse, rat MIR4659A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MIR4659A DNA Methylation CpG Assay Predesigned for Pyrosequencing in human mouse rat Predesigned siRNA for gene silencing in human mouse rat QuantiFast Probe-based Assays in human mouse rat QuantiTect SYBR Green Assays in human mouse rat Custom PCR Arrays for MIR4659A Search Chromatin IP Primers for MIR4659A Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MIR4659A Search GeneGlobe Interaction Network for MIR4659A Search Regulatory tfbs for MIR4659A
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR4659A
Search ThermoFisher Antibodies for MIR4659A
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR4659A
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