Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4658 Gene

Subcategory (RNA class) for MIR4658 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4658 Gene

  • MicroRNA 4658 2 3 5
  • Hsa-Mir-4658 3

External Ids for MIR4658 Gene

Previous GeneCards Identifiers for MIR4658 Gene

  • GC07U903182
  • GC07M099761
  • GC07M099771
  • GC07M099791

Summaries for MIR4658 Gene

Entrez Gene Summary for MIR4658 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4658 Gene

MIR4658 (MicroRNA 4658) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4658 Gene

Genomics for MIR4658 Gene

Regulatory Elements for MIR4658 Gene

Enhancers for MIR4658 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G100151 1.1 Ensembl ENCODE 0.7 +4.3 4286 1.2 HDAC1 CTCF PKNOX1 ESRRA MAX ZBTB40 ZNF121 ZNF316 POLR2A ZSCAN5C MIR4658 LAMTOR4
GH07G100153 1.1 ENCODE 0.7 +0.3 340 6.4 HDGF FOXA2 PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 AP4M1 ZSCAN25 ENSG00000242798 MBLAC1 ZNF655 GIGYF1 PILRA LAMTOR4 STAG3L5P PPP1R35
GH07G100148 1.1 ENCODE 0.4 +7.3 7295 2.6 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 AP4M1 ZSCAN25 ZNF655 GIGYF1 PPP1R35 PVRIG STAG3 PDAP1 STAG3L5P LOC100131859
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4658 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4658 Gene

Chromosome:
7
Start:
100,156,605 bp from pter
End:
100,156,669 bp from pter
Size:
65 bases
Orientation:
Minus strand

Genomic View for MIR4658 Gene

Genes around MIR4658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4658 Gene

ORGUL Member Location for MIR4658 Gene

ORGUL Member Location for MIR4658 gene

Proteins for MIR4658 Gene

Post-translational modifications for MIR4658 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4658 Gene

Domains & Families for MIR4658 Gene

Gene Families for MIR4658 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4658: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4658 Gene

Function for MIR4658 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4658 Gene

Localization for MIR4658 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4658 Gene

Pathways & Interactions for MIR4658 Gene

SuperPathways for MIR4658 Gene

No Data Available

Interacting Proteins for MIR4658 Gene

Gene Ontology (GO) - Biological Process for MIR4658 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4658 Gene

Transcripts for MIR4658 Gene

mRNA/cDNA for MIR4658 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4658 Gene

No ASD Table

Relevant External Links for MIR4658 Gene

GeneLoc Exon Structure for
MIR4658
ECgene alternative splicing isoforms for
MIR4658

Expression for MIR4658 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4658 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4658 Gene

This gene is overexpressed in Whole Blood (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR4658 Gene:

MIR4658
genes like me logo Genes that share expression patterns with MIR4658: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4658 Gene

Orthologs for MIR4658 Gene

Evolution for MIR4658 Gene

ENSEMBL:
Gene Tree for MIR4658 (if available)
TreeFam:
Gene Tree for MIR4658 (if available)

No data available for Orthologs for MIR4658 Gene

Paralogs for MIR4658 Gene

No data available for Paralogs for MIR4658 Gene

Variants for MIR4658 Gene

Sequence variations from dbSNP and Humsavar for MIR4658 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000062003 -- 100,158,472(+) GAAGT(-/A)CATCG intron-variant, upstream-variant-2KB, reference, frameshift-variant
rs1002225274 -- 100,156,135(+) GAAGT(A/G)GAGTT intron-variant, downstream-variant-500B
rs1005821422 -- 100,158,021(+) TCATC(G/T)GCCTC intron-variant, upstream-variant-2KB
rs1007871544 -- 100,157,237(+) CTTGG(C/T)TCAGA intron-variant, upstream-variant-2KB
rs1011028187 -- 100,156,478(+) GCTCG(C/T)AGGTC downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR4658 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv469687 CNV loss 16826518
nsv607931 CNV loss 21841781

Relevant External Links for MIR4658 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4658

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4658 Gene

Disorders for MIR4658 Gene

Relevant External Links for MIR4658

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4658

No disorders were found for MIR4658 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4658 Gene

Publications for MIR4658 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4658 Gene

Sources for MIR4658 Gene

Content
Loading form....