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Aliases for MIR4658 Gene

Subcategory (RNA class) for MIR4658 Gene


Quality Score for this RNA gene is


Aliases for MIR4658 Gene

  • MicroRNA 4658 2 3
  • C7orf43 4 5
  • Chromosome 7 Open Reading Frame 43 5
  • Hsa-Mir-4658 3

External Ids for MIR4658 Gene

Previous GeneCards Identifiers for MIR4658 Gene

  • GC07U903182
  • GC07M099761
  • GC07M099771
  • GC07M099791

Summaries for MIR4658 Gene

Entrez Gene Summary for MIR4658 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4658 Gene

MIR4658 (MicroRNA 4658) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4658 Gene

Genomics for MIR4658 Gene

Regulatory Elements for MIR4658 Gene

Enhancers for MIR4658 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100137 1.1 Ensembl ENCODE 12.6 +20.5 20531 0.8 GATA3 PKNOX1 IKZF1 TCF7 NFE2 TCF7L2 PVRIG C7orf43 MIR4658 GAL3ST4 GPC2 STAG3 GATS MCM7 AP4M1 MIR106B
GH07F100187 1 FANTOM5 12.5 -28.9 -28881 0.3 SCRT2 GATS MIR4658 C7orf43 LAMTOR4 PVRIG MCM7 ZKSCAN1 LOC102724025 STAG3
GH07F100189 1.2 Ensembl ENCODE 12.1 -33.1 -33056 3.9 HDGF HDAC1 ZBTB40 RAD21 YY1 GATA2 SCRT2 SMARCA5 CEBPB REST PVRIG AP4M1 GATS GAL3ST4 C7orf43 MIR4658 LAMTOR4 RPL7P60 ZCWPW1 LOC102724025
GH07F100195 0.2 ENCODE 12 -37.2 -37166 1.3 PTRF CEBPG ZNF7 IRF9 SCRT2 PRDM10 CREM STAT1 MTA2 TRIM22 AP4M1 GAL3ST4 MIR4658 C7orf43 LAMTOR4 LOC102724025 GC07M100212 PIR36589
GH07F100199 1 Ensembl ENCODE 11.8 -42.0 -41958 1.5 HDGF HDAC1 ATF1 CBX3 PKNOX1 ARNT NFRKB SIN3A GATA2 EGR1 PVRIG GPC2 STAG3 GAL3ST4 MIR4658 C7orf43 LAMTOR4 LOC102724025 PIR36589 GC07M100212
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4658 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4658 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR4658 Gene

100,154,420 bp from pter
100,158,715 bp from pter
4,296 bases
Minus strand

Genomic View for MIR4658 Gene

Genes around MIR4658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4658 Gene

Proteins for MIR4658 Gene

  • Protein details for MIR4658 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C7orf43
    Protein Accession:
    Secondary Accessions:
    • A4D2A9
    • D6W5U4
    • Q9BQJ1
    • Q9BUB6
    • Q9NV47

    Protein attributes for MIR4658 Gene

    580 amino acids
    Molecular mass:
    62597 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB66490.1; Type=Frameshift; Positions=539; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR4658 Gene


neXtProt entry for MIR4658 Gene

Post-translational modifications for MIR4658 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR4658 Gene

Domains & Families for MIR4658 Gene

Gene Families for MIR4658 Gene

Protein Domains for MIR4658 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4658: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4658 Gene

Function for MIR4658 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4658 Gene

Localization for MIR4658 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4658 Gene

Pathways & Interactions for MIR4658 Gene

SuperPathways for MIR4658 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4658 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4658 Gene

Transcripts for MIR4658 Gene

mRNA/cDNA for MIR4658 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4658 Gene

No ASD Table

Relevant External Links for MIR4658 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4658 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4658 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4658 Gene

This gene is overexpressed in Whole Blood (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR4658 Gene:

genes like me logo Genes that share expression patterns with MIR4658: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4658 Gene

Orthologs for MIR4658 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4658 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C7ORF43 35
  • 100 (a)
(Bos Taurus)
Mammalia C7orf43 35
  • 98 (a)
(Canis familiaris)
Mammalia C7orf43 35
  • 97 (a)
(Mus musculus)
Mammalia BC037034 35 35
  • 96 (a)
(Monodelphis domestica)
Mammalia C7orf43 35
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia C7orf43 35
  • 89 (a)
(Danio rerio)
Actinopterygii C7H7orf43 35
  • 63 (a)
Species where no ortholog for MIR4658 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4658 Gene

Gene Tree for MIR4658 (if available)
Gene Tree for MIR4658 (if available)

Paralogs for MIR4658 Gene

No data available for Paralogs for MIR4658 Gene

Variants for MIR4658 Gene

Sequence variations from dbSNP and Humsavar for MIR4658 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs112784768 -- 100,156,258(+) GCCAC(C/T)TGCCA intron-variant, downstream-variant-500B
rs114824692 -- 100,157,020(+) GCATG(C/G)TCTCC intron-variant, upstream-variant-2KB
rs11764584 -- 100,156,247(+) ACAGG(A/G)CGGAA intron-variant, downstream-variant-500B
rs117793118 -- 100,157,720(+) TCTGA(C/T)CTCTG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs13245522 -- 100,158,275(+) GTTGC(A/C)AGTTC intron-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR4658 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv469687 CNV loss 16826518
nsv607931 CNV loss 21841781

Relevant External Links for MIR4658 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4658 Gene

Disorders for MIR4658 Gene

Relevant External Links for MIR4658

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4658 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4658 Gene

Publications for MIR4658 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4658 Gene

Sources for MIR4658 Gene

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