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Aliases for MIR4658 Gene

Subcategory (RNA class) for MIR4658 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4658 Gene

  • MicroRNA 4658 2 3
  • C7orf43 4 5
  • Chromosome 7 Open Reading Frame 43 5
  • Hsa-Mir-4658 3

External Ids for MIR4658 Gene

Previous GeneCards Identifiers for MIR4658 Gene

  • GC07U903182
  • GC07M099761
  • GC07M099771
  • GC07M099791

Summaries for MIR4658 Gene

Entrez Gene Summary for MIR4658 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4658 Gene

MIR4658 (MicroRNA 4658) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4658 Gene

Genomics for MIR4658 Gene

Regulatory Elements for MIR4658 Gene

Enhancers for MIR4658 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR4658 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4658 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR4658 Gene

Chromosome:
7
Start:
100,154,420 bp from pter
End:
100,158,715 bp from pter
Size:
4,296 bases
Orientation:
Minus strand

Genomic View for MIR4658 Gene

Genes around MIR4658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4658 Gene

ORGUL Member Location for MIR4658 Gene

ORGUL Member Location for MIR4658 gene

Proteins for MIR4658 Gene

  • Protein details for MIR4658 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVR3-CG043_HUMAN
    Recommended name:
    Uncharacterized protein C7orf43
    Protein Accession:
    Q8WVR3
    Secondary Accessions:
    • A4D2A9
    • D6W5U4
    • Q9BQJ1
    • Q9BUB6
    • Q9NV47

    Protein attributes for MIR4658 Gene

    Size:
    580 amino acids
    Molecular mass:
    62597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66490.1; Type=Frameshift; Positions=539; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR4658 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4658 Gene

Post-translational modifications for MIR4658 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR4658 Gene

Domains & Families for MIR4658 Gene

Gene Families for MIR4658 Gene

Protein Domains for MIR4658 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4658: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4658 Gene

Function for MIR4658 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4658 Gene

Localization for MIR4658 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4658 Gene

Pathways & Interactions for MIR4658 Gene

SuperPathways for MIR4658 Gene

No Data Available

Interacting Proteins for MIR4658 Gene

Gene Ontology (GO) - Biological Process for MIR4658 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4658 Gene

Drugs & Compounds for MIR4658 Gene

No Compound Related Data Available

Transcripts for MIR4658 Gene

mRNA/cDNA for MIR4658 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4658 Gene

No ASD Table

Relevant External Links for MIR4658 Gene

GeneLoc Exon Structure for
MIR4658
ECgene alternative splicing isoforms for
MIR4658

Expression for MIR4658 Gene

mRNA expression in normal human tissues for MIR4658 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4658 Gene

This gene is overexpressed in Whole Blood (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR4658 Gene:

MIR4658
genes like me logo Genes that share expression patterns with MIR4658: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4658 Gene

Orthologs for MIR4658 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4658 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C7orf43 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7orf43 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C7orf43 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC037034 35
  • 96 (a)
OneToMany
BC037034 35
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C7orf43 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C7ORF43 35
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C7H7orf43 35
  • 63 (a)
OneToOne
Species where no ortholog for MIR4658 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4658 Gene

ENSEMBL:
Gene Tree for MIR4658 (if available)
TreeFam:
Gene Tree for MIR4658 (if available)

Paralogs for MIR4658 Gene

No data available for Paralogs for MIR4658 Gene

Variants for MIR4658 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4658 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv469687 CNV loss 16826518
nsv607931 CNV loss 21841781

Relevant External Links for MIR4658 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4658

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4658 Gene

Disorders for MIR4658 Gene

Relevant External Links for MIR4658

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4658

No disorders were found for MIR4658 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4658 Gene

Publications for MIR4658 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 65
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 65
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 65

Products for MIR4658 Gene

Sources for MIR4658 Gene

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