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Aliases for MIR4657 Gene

Subcategory (RNA class) for MIR4657 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4657 Gene

  • MicroRNA 4657 2 3
  • PURB 4 5
  • Purine-Rich Element-Binding Protein B 4
  • Purine Rich Element Binding Protein B 5
  • Hsa-Mir-4657 3
  • Mir-4657 3

External Ids for MIR4657 Gene

Previous GeneCards Identifiers for MIR4657 Gene

  • GC07U903199
  • GC07M044931
  • GC07M044932
  • GC07M044935
  • GC07M044881
  • GC07M044880

Summaries for MIR4657 Gene

Entrez Gene Summary for MIR4657 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4657 Gene

MIR4657 (MicroRNA 4657) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4657 include Myelodysplastic Syndrome. An important paralog of this gene is PURA.

UniProtKB/Swiss-Prot for MIR4657 Gene

  • Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4657 Gene

Genomics for MIR4657 Gene

Regulatory Elements for MIR4657 Gene

Enhancers for MIR4657 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F044915 1.4 FANTOM5 Ensembl ENCODE 12.3 -29.9 -29882 0.3 CBX3 PKNOX1 BMI1 NR2F6 CREM RFX1 MTA2 NRF1 BHLHE40 EP300 PURB MIR4657 H2AFV LINC01952 ENSG00000228596 MYO1G ZMIZ2 OGDH DDX56 CCM2
GH07F044921 1.1 Ensembl ENCODE 12.1 -36.7 -36691 0.7 PKNOX1 ARID4B SIN3A NFXL1 RAD21 GATA2 ZNF143 CREM ZNF263 ZNF654 PURB MIR4657 LINC01952 H2AFV ENSG00000228596 ZMIZ2 MRPS23P1 ENSG00000260997
GH07F044588 0.7 Ensembl 10.7 +296.9 296861 0.2 CTCF ZNF362 ZNF654 HLF CEBPB REST RAD21 ZNF2 RFX5 GATA3 H2AFV LINC01952 ENSG00000228596 PURB MIR4657 PIR35616 GC07P044582 ENSG00000271586
GH07F044589 0.7 ENCODE 10.7 +297.1 297085 0.2 CTCF ZNF362 ZNF654 HLF CEBPB TRIM22 REST ZNF2 RAD21 RFX5 H2AFV LINC01952 ENSG00000228596 PURB MIR4657 PIR35616 GC07P044582 ENSG00000271586
GH07F044912 0.5 Ensembl 12.4 -27.1 -27140 1.0 NR2F1 NR2F6 NR2F2 NR2C2 PURB MIR4657 H2AFV LINC01952 MYO1G PPIA MRPS23P1 LOC105375262
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4657 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4657 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157705 -39 2401 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for MIR4657 Gene

Chromosome:
7
Start:
44,876,293 bp from pter
End:
44,885,361 bp from pter
Size:
9,069 bases
Orientation:
Minus strand

Genomic View for MIR4657 Gene

Genes around MIR4657 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4657 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4657 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4657 Gene

Proteins for MIR4657 Gene

  • Protein details for MIR4657 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QR8-PURB_HUMAN
    Recommended name:
    Transcriptional activator protein Pur-beta
    Protein Accession:
    Q96QR8
    Secondary Accessions:
    • A4D2L7

    Protein attributes for MIR4657 Gene

    Size:
    312 amino acids
    Molecular mass:
    33241 Da
    Quaternary structure:
    • Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1.
    • Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1.
    Miscellaneous:
    • Defects in PURB may be a cause of progression of myelodysplastic syndrome (MDS) towards acute myelogenous leukemia (AML). MDS refers to a heterogeneous group of closely related hematopoietic disorders. All are characterized by a cellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. Some patients with MDS develop acute myelogenous leukemia (AML), a malignant disease in which hematopoietic precursors are arrested in an early stage of development.

neXtProt entry for MIR4657 Gene

Post-translational modifications for MIR4657 Gene

  • Ubiquitination at Lys 240
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4657 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR4657 Gene

Domains & Families for MIR4657 Gene

Gene Families for MIR4657 Gene

Protein Domains for MIR4657 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96QR8

UniProtKB/Swiss-Prot:

PURB_HUMAN :
  • Belongs to the PUR DNA-binding protein family.
Family:
  • Belongs to the PUR DNA-binding protein family.
genes like me logo Genes that share domains with MIR4657: view

No data available for Suggested Antigen Peptide Sequences for MIR4657 Gene

Function for MIR4657 Gene

Molecular function for MIR4657 Gene

UniProtKB/Swiss-Prot Function:
Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).

Gene Ontology (GO) - Molecular Function for MIR4657 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with MIR4657: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4657 Gene

Localization for MIR4657 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4657 Gene

Gene Ontology (GO) - Cellular Components for MIR4657 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005662 DNA replication factor A complex IEA --
genes like me logo Genes that share ontologies with MIR4657: view

No data available for Subcellular locations from COMPARTMENTS for MIR4657 Gene

Pathways & Interactions for MIR4657 Gene

SuperPathways for MIR4657 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4657 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008283 cell proliferation IEA --
GO:0030154 cell differentiation IEA --
GO:0045637 regulation of myeloid cell differentiation NAS --
genes like me logo Genes that share ontologies with MIR4657: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4657 Gene

Transcripts for MIR4657 Gene

mRNA/cDNA for MIR4657 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4657 Gene

No ASD Table

Relevant External Links for MIR4657 Gene

GeneLoc Exon Structure for
MIR4657
ECgene alternative splicing isoforms for
MIR4657

Expression for MIR4657 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4657 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4657 Gene:

MIR4657

mRNA Expression by UniProt/SwissProt for MIR4657 Gene:

Q96QR8-PURB_HUMAN
Tissue specificity: Expressed in myocardium of heart failure patients.
genes like me logo Genes that share expression patterns with MIR4657: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4657 Gene

Orthologs for MIR4657 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4657 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PURB 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PURB 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Purb 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PURB 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PURB 35
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii purbb 35
  • 82 (a)
OneToMany
purba 35
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pur-alpha 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea plp-1 35
  • 38 (a)
ManyToMany
plp-2 35
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for MIR4657 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4657 Gene

ENSEMBL:
Gene Tree for MIR4657 (if available)
TreeFam:
Gene Tree for MIR4657 (if available)

Paralogs for MIR4657 Gene

Paralogs for MIR4657 Gene

genes like me logo Genes that share paralogs with MIR4657: view

Variants for MIR4657 Gene

Sequence variations from dbSNP and Humsavar for MIR4657 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs112908972 -- 44,881,788(+) TCAGA(A/C)CACTT nc-transcript-variant, utr-variant-3-prime
rs113071477 -- 44,882,094(+) GCAAC(C/T)TAAAT upstream-variant-2KB, utr-variant-3-prime
rs113588361 -- 44,883,101(+) GTGCA(-/C)TGCTT upstream-variant-2KB, utr-variant-3-prime
rs139863263 -- 44,882,190(-) GAATT(A/T)GTTCT upstream-variant-2KB, utr-variant-3-prime
rs142417079 -- 44,883,715(+) GCGAA(A/G)AAAAG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4657 Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV loss 17160897

Relevant External Links for MIR4657 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4657

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4657 Gene

Disorders for MIR4657 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4657 Gene - From: GeneCards

Disorder Aliases PubMed IDs
myelodysplastic syndrome
  • myelodysplastic syndrome, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR4657

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4657
genes like me logo Genes that share disorders with MIR4657: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4657 Gene

Publications for MIR4657 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for MIR4657 Gene

Sources for MIR4657 Gene

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