Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4654 Gene

Subcategory (RNA class) for MIR4654 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4654 Gene

  • MicroRNA 4654 2 3 5
  • Hsa-Mir-4654 3
  • Mir-4654 3

External Ids for MIR4654 Gene

Previous GeneCards Identifiers for MIR4654 Gene

  • GC01U903276

Summaries for MIR4654 Gene

Entrez Gene Summary for MIR4654 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4654 Gene

MIR4654 (MicroRNA 4654) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4654 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4654 Gene

Genomics for MIR4654 Gene

GeneHancer (GH) Regulatory Elements for MIR4654 Gene

Promoters and enhancers for MIR4654 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I162156 Enhancer 0.4 ENCODE 550.8 +0.4 435 1.2 ZNF664 ZNF146 MIR4654 C1orf226 LOC105371475 NOS1AP
GH01I162151 Enhancer 1.2 ENCODE dbSUPER 0.8 -4.6 -4640 1.5 ATF1 FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 ETS1 YY1 GLIS2 USP21 PPOX C1orf226 B4GALT3 ATF6 DUSP12 LOC148430 SPATA46 MIR4654 LOC105371475
GH01I162159 Enhancer 1 ENCODE dbSUPER 0.8 +2.6 2579 0.2 PKNOX1 CLOCK NFIB NEUROD1 BMI1 E2F8 FOS RCOR1 GATAD2B ZNF398 PPOX C1orf226 SPATA46 MIR4654 LOC105371475 NOS1AP
GH01I162136 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 -19.9 -19912 1.7 RAD21 RARA RFX5 RCOR1 FOS DEK SMARCC1 RXRA CEBPB PPARG C1orf226 MIR4654 LOC105371475 GC01M162031 NOS1AP GC01P162033
GH01I162143 Enhancer 1.1 ENCODE dbSUPER 0.4 -11.9 -11910 3 ELF3 ZFP64 ARID4B MZF1 FEZF1 RAD21 RARA ZNF121 GLIS2 THAP11 C1orf226 SPATA46 MIR4654 LOC105371475 GC01M162031 NOS1AP GC01P162033
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4654 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4654 Gene

Genomic Locations for MIR4654 Gene
chr1:162,157,107-162,157,182
(GRCh38/hg38)
Size:
76 bases
Orientation:
Plus strand
chr1:162,126,897-162,126,972
(GRCh37/hg19)

Genomic View for MIR4654 Gene

Genes around MIR4654 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4654 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4654 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4654 Gene

Proteins for MIR4654 Gene

Post-translational modifications for MIR4654 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4654 Gene

Domains & Families for MIR4654 Gene

Gene Families for MIR4654 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4654: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4654 Gene

Function for MIR4654 Gene

Phenotypes From GWAS Catalog for MIR4654 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4654 Gene

Localization for MIR4654 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4654 Gene

Pathways & Interactions for MIR4654 Gene

SuperPathways for MIR4654 Gene

No Data Available

Interacting Proteins for MIR4654 Gene

Gene Ontology (GO) - Biological Process for MIR4654 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4654 Gene

Drugs & Compounds for MIR4654 Gene

No Compound Related Data Available

Transcripts for MIR4654 Gene

mRNA/cDNA for MIR4654 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4654 Gene

No ASD Table

Relevant External Links for MIR4654 Gene

GeneLoc Exon Structure for
MIR4654
ECgene alternative splicing isoforms for
MIR4654

Expression for MIR4654 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4654 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4654 Gene:

MIR4654
genes like me logo Genes that share expression patterns with MIR4654: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4654 Gene

Orthologs for MIR4654 Gene

Evolution for MIR4654 Gene

ENSEMBL:
Gene Tree for MIR4654 (if available)
TreeFam:
Gene Tree for MIR4654 (if available)

No data available for Orthologs for MIR4654 Gene

Paralogs for MIR4654 Gene

No data available for Paralogs for MIR4654 Gene

Variants for MIR4654 Gene

Sequence variations from dbSNP and Humsavar for MIR4654 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000035194 -- 162,155,988(+) G/A upstream_transcript_variant
rs1001704176 -- 162,157,680(+) C/G downstream_transcript_variant
rs1004293639 -- 162,155,559(+) G/A upstream_transcript_variant
rs1006251465 -- 162,156,908(+) G/A upstream_transcript_variant
rs1007785445 -- 162,156,947(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4654 Gene

Variant ID Type Subtype PubMed ID
esv2758973 CNV gain 17122850
esv34209 CNV gain 17911159
esv3587740 CNV gain 21293372
esv3587741 CNV gain 21293372
nsv516482 CNV gain+loss 19592680
nsv818511 CNV gain 17921354
nsv831759 CNV gain+loss 17160897

Additional Variant Information for MIR4654 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4654

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4654 Gene

Disorders for MIR4654 Gene

Additional Disease Information for MIR4654

No disorders were found for MIR4654 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4654 Gene

Publications for MIR4654 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4654 Gene

Sources for MIR4654 Gene

Content
Loading form....