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Aliases for MIR4653 Gene

Subcategory (RNA class) for MIR4653 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4653 Gene

  • MicroRNA 4653 2 3 5
  • Hsa-Mir-4653 3

External Ids for MIR4653 Gene

Previous GeneCards Identifiers for MIR4653 Gene

  • GC07U903187
  • GC07P100805

Summaries for MIR4653 Gene

Entrez Gene Summary for MIR4653 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4653 Gene

MIR4653 (MicroRNA 4653) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4653 Gene

Genomics for MIR4653 Gene

Regulatory Elements for MIR4653 Gene

Enhancers for MIR4653 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F101159 0.9 Ensembl ENCODE 0.8 +2.6 2642 5.6 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF766 ZNF143 FOS ZNF263 AP1S1 NAT16 RN7SL750P RN7SL416P NYAP1 GIGYF1 PPP1R35 FIS1 STAG3L5P AZGP1P2
GH07F101153 0.2 ENCODE 0.8 -3.7 -3699 3.9 HDGF PKNOX1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF263 AP1S1 GIGYF1 NAT16 STAG3L5P SERPINE1 NYAP1 FIS1 AZGP1P2 LNCPRESS1 PPP1R35
GH07F101165 1 FANTOM5 Ensembl ENCODE 0.4 +7.0 7021 2.8 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS NYAP1 AP1S1 NAT16 MOSPD3 TSC22D4 VGF MIR4653
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4653 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4653 Gene

Chromosome:
7
Start:
101,159,473 bp from pter
End:
101,159,555 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR4653 Gene

Genes around MIR4653 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4653 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4653 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4653 Gene

Proteins for MIR4653 Gene

Post-translational modifications for MIR4653 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4653 Gene

Domains & Families for MIR4653 Gene

Gene Families for MIR4653 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4653: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4653 Gene

Function for MIR4653 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4653 Gene

Localization for MIR4653 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4653 Gene

Pathways & Interactions for MIR4653 Gene

SuperPathways for MIR4653 Gene

No Data Available

Interacting Proteins for MIR4653 Gene

Gene Ontology (GO) - Biological Process for MIR4653 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4653 Gene

Transcripts for MIR4653 Gene

mRNA/cDNA for MIR4653 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4653 Gene

No ASD Table

Relevant External Links for MIR4653 Gene

GeneLoc Exon Structure for
MIR4653
ECgene alternative splicing isoforms for
MIR4653

Expression for MIR4653 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4653 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4653 Gene:

MIR4653
genes like me logo Genes that share expression patterns with MIR4653: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4653 Gene

Orthologs for MIR4653 Gene

Evolution for MIR4653 Gene

ENSEMBL:
Gene Tree for MIR4653 (if available)
TreeFam:
Gene Tree for MIR4653 (if available)

No data available for Orthologs for MIR4653 Gene

Paralogs for MIR4653 Gene

No data available for Paralogs for MIR4653 Gene

Variants for MIR4653 Gene

Sequence variations from dbSNP and Humsavar for MIR4653 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10245661 -- 101,159,287(+) CCCAC(C/T)GTCGC intron-variant, upstream-variant-2KB
rs112066382 -- 101,158,136(+) GCATT(A/G)GAGTT intron-variant, upstream-variant-2KB
rs116399991 -- 101,157,809(+) CCTAT(C/T)ACCTG intron-variant, upstream-variant-2KB
rs117188154 -- 101,157,728(+) AGCTC(A/G)GACTT intron-variant, upstream-variant-2KB
rs117675097 -- 101,159,618(+) TTTTT(C/T)TTTTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4653 Gene

Variant ID Type Subtype PubMed ID
esv2422376 CNV duplication 17116639
esv2734888 CNV deletion 23290073
esv2752134 CNV gain 17911159
nsv1018841 CNV gain 25217958
nsv1030604 CNV gain 25217958
nsv607972 CNV loss 21841781
nsv607973 CNV loss 21841781
nsv607974 CNV loss 21841781
nsv831075 CNV loss 17160897

Relevant External Links for MIR4653 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4653

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4653 Gene

Disorders for MIR4653 Gene

Relevant External Links for MIR4653

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4653

No disorders were found for MIR4653 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4653 Gene

Publications for MIR4653 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4653 Gene

Sources for MIR4653 Gene

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