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Aliases for MIR4651 Gene

Subcategory (RNA class) for MIR4651 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4651 Gene

  • MicroRNA 4651 2 3
  • EC 1.6.2.4 4 61
  • Cytochrome P450 Oxidoreductase 5
  • Hsa-Mir-4651 3
  • Mir-4651 3
  • CYPOR 4
  • P450R 4
  • CPR 4
  • POR 5

External Ids for MIR4651 Gene

Previous GeneCards Identifiers for MIR4651 Gene

  • GC07U903198
  • GC07P075547

Summaries for MIR4651 Gene

Entrez Gene Summary for MIR4651 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4651 Gene

MIR4651 (MicroRNA 4651) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4651 include Cytochrome P450 Oxidoreductase Deficiency and Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. An important paralog of this gene is NOS1.

UniProtKB/Swiss-Prot for MIR4651 Gene

  • This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4651 Gene

Genomics for MIR4651 Gene

Regulatory Elements for MIR4651 Gene

Enhancers for MIR4651 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F075953 0.7 Ensembl ENCODE 13 +59.6 59560 10.7 PKNOX1 MLX ARID4B DMAP1 FOS PAF1 REST PPARG KAT8 SMARCA4 POR ZP3 MIR4651 CCL26 RHBDD2 CCL24 SRRM3 ENSG00000230882 UPK3B MDH2
GH07F075971 1.3 FANTOM5 Ensembl ENCODE 12.3 +72.9 72921 1.5 CTCF NR2F1 CEBPB ZNF2 RAD21 NR2F2 IKZF1 HNF4G ETV6 NR2F6 STYXL1 SNORA14A MIR4651 POR CCL26 CCL24 SRRM3 ENSG00000230882 TMEM120A GC07P075946
GH07F076008 1 Ensembl ENCODE 11.9 +111.4 111365 4.7 ATF1 ZNF133 SIN3A GLI4 ZNF2 GLIS2 ZNF766 ZNF207 KLF7 ZNF263 STYXL1 MDH2 STAG3L1 ENSG00000230882 DTX2P1 NSUN5P1 SNORA14A MIR4651 POR RHBDD2
GH07F075964 0.9 FANTOM5 Ensembl ENCODE 11.6 +68.3 68345 5.4 HDAC1 GATA2 ZNF366 ETV6 FOS CREM JUNB USF2 ZEB2 REST STYXL1 POR SNORA14A MIR4651 CCL24 SRRM3 ENSG00000230882 MDH2 ZP3 GC07P075946
GH07F075841 0.6 Ensembl ENCODE 11.3 -56.0 -56031 2.5 ATF1 FOS KDM4B KLF13 GTF2B JUNB REST TBX21 ZNF592 CREB3 LOC100133091 CCL26 MIR4651 POR SNORA14A NSUN5P1 CCL24 STAG3L1 SRRM3 RHBDD2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4651 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4651 Gene

Chromosome:
7
Start:
75,899,200 bp from pter
End:
75,986,855 bp from pter
Size:
87,656 bases
Orientation:
Plus strand

Genomic View for MIR4651 Gene

Genes around MIR4651 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4651 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4651 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4651 Gene

Proteins for MIR4651 Gene

  • Protein details for MIR4651 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16435-NCPR_HUMAN
    Recommended name:
    NADPH--cytochrome P450 reductase
    Protein Accession:
    P16435
    Secondary Accessions:
    • Q16455
    • Q197M5
    • Q8N181
    • Q9H3M8
    • Q9UDT3

    Protein attributes for MIR4651 Gene

    Size:
    677 amino acids
    Molecular mass:
    76690 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34277.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR4651 Gene

neXtProt entry for MIR4651 Gene

Post-translational modifications for MIR4651 Gene

  • Ubiquitination at Lys 56 and Lys 487
  • Modification sites at PhosphoSitePlus

Domains & Families for MIR4651 Gene

Gene Families for MIR4651 Gene

Graphical View of Domain Structure for InterPro Entry

P16435

UniProtKB/Swiss-Prot:

NCPR_HUMAN :
  • Contains 1 FAD-binding FR-type domain.
  • Belongs to the NADPH--cytochrome P450 reductase family.
Domain:
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 flavodoxin-like domain.
Family:
  • Belongs to the NADPH--cytochrome P450 reductase family.
  • In the N-terminal section; belongs to the flavodoxin family.
  • In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with MIR4651: view

No data available for Suggested Antigen Peptide Sequences for MIR4651 Gene

Function for MIR4651 Gene

Molecular function for MIR4651 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
UniProtKB/Swiss-Prot Function:
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Enzyme Numbers (IUBMB) for MIR4651 Gene

Gene Ontology (GO) - Molecular Function for MIR4651 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003958 NADPH-hemoprotein reductase activity IEA --
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H IEA --
GO:0008941 nitric oxide dioxygenase activity IEA --
GO:0009055 electron carrier activity IEA --
GO:0010181 FMN binding IEA --
genes like me logo Genes that share ontologies with MIR4651: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4651 Gene

Localization for MIR4651 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4651 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Gene Ontology (GO) - Cellular Components for MIR4651 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MIR4651: view

No data available for Subcellular locations from COMPARTMENTS for MIR4651 Gene

Pathways & Interactions for MIR4651 Gene

genes like me logo Genes that share pathways with MIR4651: view

Pathways by source for MIR4651 Gene

Gene Ontology (GO) - Biological Process for MIR4651 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0007584 response to nutrient IEA --
GO:0009437 carnitine metabolic process IEA --
GO:0009812 flavonoid metabolic process IEA --
GO:0018393 internal peptidyl-lysine acetylation IEA --
genes like me logo Genes that share ontologies with MIR4651: view

No data available for SIGNOR curated interactions for MIR4651 Gene

Transcripts for MIR4651 Gene

mRNA/cDNA for MIR4651 Gene

(25) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4651 Gene

No ASD Table

Relevant External Links for MIR4651 Gene

GeneLoc Exon Structure for
MIR4651
ECgene alternative splicing isoforms for
MIR4651

Expression for MIR4651 Gene

mRNA expression in normal human tissues for MIR4651 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4651 Gene:

MIR4651
genes like me logo Genes that share expression patterns with MIR4651: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4651 Gene

Orthologs for MIR4651 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR4651 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POR 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POR 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Por 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POR 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 4 (a)
ManyToMany
chicken
(Gallus gallus)
Aves POR 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POR 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii POR (2 of 2) 35
  • 75 (a)
OneToMany
por 35
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cpr 35
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea emb-8 35
  • 48 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NCP1 35
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1215 35
  • 51 (a)
OneToOne
Species where no ortholog for MIR4651 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4651 Gene

ENSEMBL:
Gene Tree for MIR4651 (if available)
TreeFam:
Gene Tree for MIR4651 (if available)

Paralogs for MIR4651 Gene

Paralogs for MIR4651 Gene

genes like me logo Genes that share paralogs with MIR4651: view

Variants for MIR4651 Gene

Sequence variations from dbSNP and Humsavar for MIR4651 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs12537282 -- 75,914,894(+) GCCGC(C/T)GTCTC upstream-variant-2KB
rs139824475 -- 75,914,984(+) CCGGG(C/T)CGGGC upstream-variant-2KB
rs144810057 -- 75,914,073(+) AGCTA(A/G)TAATA upstream-variant-2KB
rs148556916 -- 75,914,362(+) AGGCA(C/G)CGTGT upstream-variant-2KB
rs149371800 -- 75,913,630(+) AATAT(A/G)TAAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4651 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
esv3571928 CNV loss 25503493
esv3613742 CNV loss 21293372
nsv528969 CNV gain 19592680

Relevant External Links for MIR4651 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4651

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4651 Gene

Disorders for MIR4651 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR4651 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cytochrome p450 oxidoreductase deficiency
  • antley-bixler syndrome
antley-bixler syndrome with genital anomalies and disordered steroidogenesis
  • antley-bixler syndrome, with genital anomalies and disordered steroidogenesis
disordered steroidogenesis due to cytochrome p450 oxidoreductase
  • cytochrome p450 oxidoreductase deficiency
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NCPR_HUMAN
  • Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis (ABS1) [MIM:201750]: A disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures. {ECO:0000269 PubMed:14758361, ECO:0000269 PubMed:15264278, ECO:0000269 PubMed:15483095}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD) [MIM:613571]: A disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome. {ECO:0000269 PubMed:14758361, ECO:0000269 PubMed:15220035}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR4651

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4651
genes like me logo Genes that share disorders with MIR4651: view

No data available for Genatlas for MIR4651 Gene

Publications for MIR4651 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64

Products for MIR4651 Gene

Sources for MIR4651 Gene

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