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Aliases for MIR4649 Gene

Subcategory (RNA class) for MIR4649 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4649 Gene

  • MicroRNA 4649 2 3 5
  • Hsa-Mir-4649 3
  • Mir-4649 3

External Ids for MIR4649 Gene

Previous GeneCards Identifiers for MIR4649 Gene

  • GC07U903197
  • GC07P044154

Summaries for MIR4649 Gene

Entrez Gene Summary for MIR4649 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4649 Gene

MIR4649 (MicroRNA 4649) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4649 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4649 Gene

Genomics for MIR4649 Gene

Regulatory Elements for MIR4649 Gene

Enhancers for MIR4649 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H044111 1.1 Ensembl dbSUPER 0.7 +2.0 1987 2 PTBP1 GLIS2 EGR1 SCRT2 ATF7 CREM EGR2 ZNF202 SP3 ZEB2 DDX56 POLM SNORA5C ENSG00000228434 TMED4 SNHG15 SNORA5A SPDYE1 SNORA5B GCK
GH07H044114 0.7 ENCODE dbSUPER 0.7 +4.3 4327 1 POLR2A ZIC2 SUPT5H POLM MIR4649 POLD2
GH07H044121 1.1 ENCODE 0.4 +12.2 12191 3 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS ENSG00000228680 DDX56 POLM TMED4 SPDYE1 SNORA5B ENSG00000228434 SNORA5C SNHG15 TBRG4
GH07H044106 0.4 dbSUPER 0.7 -3.6 -3606 0 GLIS1 ZIC2 POLM ENSG00000239556 AEBP1 MIR4649
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4649 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4649 Gene

Chromosome:
7
Start:
44,110,849 bp from pter
End:
44,110,912 bp from pter
Size:
64 bases
Orientation:
Plus strand

Genomic View for MIR4649 Gene

Genes around MIR4649 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4649 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4649 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4649 Gene

Proteins for MIR4649 Gene

Post-translational modifications for MIR4649 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4649 Gene

Domains & Families for MIR4649 Gene

Gene Families for MIR4649 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4649: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4649 Gene

Function for MIR4649 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4649
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4649 Gene

Localization for MIR4649 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4649 Gene

Pathways & Interactions for MIR4649 Gene

SuperPathways for MIR4649 Gene

No Data Available

Interacting Proteins for MIR4649 Gene

Gene Ontology (GO) - Biological Process for MIR4649 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4649 Gene

Drugs & Compounds for MIR4649 Gene

No Compound Related Data Available

Transcripts for MIR4649 Gene

mRNA/cDNA for MIR4649 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4649
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4649 Gene

No ASD Table

Relevant External Links for MIR4649 Gene

GeneLoc Exon Structure for
MIR4649
ECgene alternative splicing isoforms for
MIR4649

Expression for MIR4649 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4649 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4649 Gene:

MIR4649
genes like me logo Genes that share expression patterns with MIR4649: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4649 Gene

Orthologs for MIR4649 Gene

Evolution for MIR4649 Gene

ENSEMBL:
Gene Tree for MIR4649 (if available)
TreeFam:
Gene Tree for MIR4649 (if available)

No data available for Orthologs for MIR4649 Gene

Paralogs for MIR4649 Gene

No data available for Paralogs for MIR4649 Gene

Variants for MIR4649 Gene

Sequence variations from dbSNP and Humsavar for MIR4649 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1001386189 -- 44,110,489(+) CCTGC(C/G)CATCC intron-variant, upstream-variant-2KB
rs1006189122 -- 44,111,211(+) TTTCC(A/G)GCACC downstream-variant-500B, reference, missense
rs1006949301 -- 44,110,795(+) CCAAC(A/G)GCTAT upstream-variant-2KB, reference, missense
rs1008679990 -- 44,111,136(+) AGACA(A/C)CCCCG intron-variant, downstream-variant-500B
rs1008733771 -- 44,109,031(+) TGGGG(C/T)CTGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4649 Gene

Variant ID Type Subtype PubMed ID
dgv11297n54 CNV loss 21841781
nsv428165 CNV gain 18775914
nsv470210 CNV loss 18288195
nsv606747 CNV gain 21841781
nsv606749 CNV loss 21841781
nsv8082 CNV gain 18304495
nsv830983 CNV loss 17160897

Relevant External Links for MIR4649 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4649

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4649 Gene

Disorders for MIR4649 Gene

Relevant External Links for MIR4649

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4649

No disorders were found for MIR4649 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4649 Gene

Publications for MIR4649 Gene

  1. MicroRNA-4649-3p inhibits cell proliferation by targeting protein tyrosine phosphatase SHP-1 in nasopharyngeal carcinoma cells. (PMID: 26081980) Pan X … Wu G (International journal of molecular medicine 2015) 3 60
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 60
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4649 Gene

Sources for MIR4649 Gene

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