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Aliases for MIR4649 Gene

Subcategory (RNA class) for MIR4649 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4649 Gene

  • MicroRNA 4649 2 3
  • AEBP1 4 5
  • Aortic Carboxypeptidase-Like Protein 4
  • AE-Binding Protein 1 4
  • AE Binding Protein 1 5
  • Hsa-Mir-4649 3
  • Mir-4649 3
  • ACLP 4

External Ids for MIR4649 Gene

Previous GeneCards Identifiers for MIR4649 Gene

  • GC07U903197
  • GC07P044154

Summaries for MIR4649 Gene

Entrez Gene Summary for MIR4649 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4649 Gene

MIR4649 (MicroRNA 4649) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is CPXM2.

UniProtKB/Swiss-Prot for MIR4649 Gene

  • May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4649 Gene

Genomics for MIR4649 Gene

Regulatory Elements for MIR4649 Gene

Enhancers for MIR4649 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F044200 1.1 ENCODE 25.2 +97.0 96965 2.0 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 KLF13 ZNF263 SP3 MIR4649 AEBP1 MIR6838 POLM YKT6 NUDCD3 SNORA5B CAMK2B PIR57733
GH07F043868 0.2 ENCODE 14.1 -234.5 -234469 3.5 HDGF PKNOX1 ARID4B SIN3A FEZF1 YY1 FOS ZNF263 SP3 SP5 URGCP POLM MIR4649 ENSG00000239556 MRPL32 PSMA2 ENSG00000241057 LINC00957 RASA4CP MRPS24
GH07F044488 0.6 ENCODE 14 +385.9 385930 2.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 NUDCD3 MIR4649 TBRG4 DDX56 SNORA5B GC07M044472 GC07M044473
GH07F044845 1.2 ENCODE 14 +743.2 743223 4.2 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 MIR4649 CICP20 TBRG4 SNHG15 SNORA5B PPIA ZMIZ2 H2AFV PIR39901
GH07F044880 0.8 ENCODE 14 +780.7 780735 9.8 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 H2AFV MIR4649 LINC01952 SNHG15 MYO1G ENSG00000228596 SNORA5B PPIA ZMIZ2 ENSG00000272768
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4649 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4649 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001559491 539 1801 ZNF263 CTCF HLF CEBPB ZIC2 ZBTB7A RAD21 HIC1 ZNF664 JUND

Genomic Location for MIR4649 Gene

Chromosome:
7
Start:
44,104,361 bp from pter
End:
44,114,562 bp from pter
Size:
10,202 bases
Orientation:
Plus strand

Genomic View for MIR4649 Gene

Genes around MIR4649 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4649 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4649 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4649 Gene

Proteins for MIR4649 Gene

  • Protein details for MIR4649 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUX7-AEBP1_HUMAN
    Recommended name:
    Adipocyte enhancer-binding protein 1
    Protein Accession:
    Q8IUX7
    Secondary Accessions:
    • Q14113
    • Q59ER7
    • Q6ZSC7
    • Q7KZ79

    Protein attributes for MIR4649 Gene

    Size:
    1158 amino acids
    Molecular mass:
    130929 Da
    Quaternary structure:
    • Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. May interact with calmodulin. Binds to DNA in vitro.
    • Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. May interact with calmodulin. Binds to DNA in vitro.
    SequenceCaution:
    • Sequence=BAD92981.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR4649 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4649 Gene

Post-translational modifications for MIR4649 Gene

No data available for DME Specific Peptides for MIR4649 Gene

Domains & Families for MIR4649 Gene

Gene Families for MIR4649 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IUX7

UniProtKB/Swiss-Prot:

AEBP1_HUMAN :
  • Contains 1 F5/8 type C domain.
  • Belongs to the peptidase M14 family.
Domain:
  • Contains 1 F5/8 type C domain.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with MIR4649: view

No data available for Suggested Antigen Peptide Sequences for MIR4649 Gene

Function for MIR4649 Gene

Molecular function for MIR4649 Gene

UniProtKB/Swiss-Prot Function:
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for MIR4649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IMP --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS --
GO:0003714 transcription corepressor activity IEA --
genes like me logo Genes that share ontologies with MIR4649: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4649 Gene

Localization for MIR4649 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4649 Gene

Isoform 1: Secreted.
Isoform 2: Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for MIR4649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0031012 extracellular matrix IDA --
genes like me logo Genes that share ontologies with MIR4649: view

No data available for Subcellular locations from COMPARTMENTS for MIR4649 Gene

Pathways & Interactions for MIR4649 Gene

SuperPathways for MIR4649 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
genes like me logo Genes that share ontologies with MIR4649: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4649 Gene

Transcripts for MIR4649 Gene

mRNA/cDNA for MIR4649 Gene

(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4649 Gene

No ASD Table

Relevant External Links for MIR4649 Gene

GeneLoc Exon Structure for
MIR4649
ECgene alternative splicing isoforms for
MIR4649

Expression for MIR4649 Gene

mRNA expression in normal human tissues for MIR4649 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4649 Gene:

MIR4649

mRNA Expression by UniProt/SwissProt for MIR4649 Gene:

Q8IUX7-AEBP1_HUMAN
Tissue specificity: Expressed in osteoblast and visceral fat.
genes like me logo Genes that share expression patterns with MIR4649: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4649 Gene

Orthologs for MIR4649 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4649 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AEBP1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AEBP1 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aebp1 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AEBP1 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AEBP1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AEBP1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves AEBP1 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AEBP1 35
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii aebp1 35
  • 49 (a)
OneToMany
AEBP1 (1 of 2) 35
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for MIR4649 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4649 Gene

ENSEMBL:
Gene Tree for MIR4649 (if available)
TreeFam:
Gene Tree for MIR4649 (if available)

Paralogs for MIR4649 Gene

Paralogs for MIR4649 Gene

genes like me logo Genes that share paralogs with MIR4649: view

Variants for MIR4649 Gene

Sequence variations from dbSNP and Humsavar for MIR4649 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs111364782 -- 44,110,013(+) TCCTC(A/C/T)GAGTG upstream-variant-2KB, splice-acceptor-variant
rs111432948 -- 44,110,014(+) CCTCA(A/C/G)AGTGT upstream-variant-2KB, splice-acceptor-variant
rs111792267 -- 44,111,240(+) GCCAG(C/G)TTGGG downstream-variant-500B, splice-donor-variant
rs111888664 -- 44,110,045(+) ACACC(A/G)TATTG upstream-variant-2KB, reference, missense
rs112006720 -- 44,109,106(+) TTCCA(A/C/G)AGAAA upstream-variant-2KB, splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4649 Gene

Variant ID Type Subtype PubMed ID
dgv11297n54 CNV loss 21841781
nsv428165 CNV gain 18775914
nsv470210 CNV loss 18288195
nsv606747 CNV gain 21841781
nsv606749 CNV loss 21841781
nsv8082 CNV gain 18304495
nsv830983 CNV loss 17160897

Relevant External Links for MIR4649 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4649

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4649 Gene

Disorders for MIR4649 Gene

Relevant External Links for MIR4649

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4649

No disorders were found for MIR4649 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4649 Gene

Publications for MIR4649 Gene

  1. MicroRNA-4649-3p inhibits cell proliferation by targeting protein tyrosine phosphatase SHP-1 in nasopharyngeal carcinoma cells. (PMID: 26081980) Pan X. … Wu G. (Int. J. Mol. Med. 2015) 3 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  5. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PMID: 19159218) Chen R. … Zou H. (J. Proteome Res. 2009) 4 64

Products for MIR4649 Gene

Sources for MIR4649 Gene

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