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Aliases for MIR4647 Gene

Subcategory (RNA class) for MIR4647 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4647 Gene

  • MicroRNA 4647 2 3
  • Solute Carrier Family 35 Member B2 4 5
  • SLC35B2 4 5
  • Putative NF-Kappa-B-Activating Protein 48 4
  • Putative MAPK-Activating Protein PM15 4
  • PAPS Transporter 1 4
  • Hsa-Mir-4647 3
  • Mir-4647 3
  • PAPST1 4

External Ids for MIR4647 Gene

Previous GeneCards Identifiers for MIR4647 Gene

  • GC06U902218

Summaries for MIR4647 Gene

Entrez Gene Summary for MIR4647 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4647 Gene

MIR4647 (MicroRNA 4647) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. An important paralog of this gene is SLC35B1.

UniProtKB/Swiss-Prot for MIR4647 Gene

  • Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4647 Gene

Genomics for MIR4647 Gene

Regulatory Elements for MIR4647 Gene

Enhancers for MIR4647 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F044232 1.8 FANTOM5 Ensembl ENCODE 11.9 +22.0 22013 6.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLH CAPN11 RPS2P29 NFKBIE SLC35B2 MIR4647 MRPL14 TMEM63B TMEM151B LOC101929726
GH06F044056 1.9 FANTOM5 Ensembl ENCODE 10.1 +195.1 195124 13.1 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A YY1 SLC30A9 CBX5 POLH NFKBIE AARS2 RPS2P29 MRPL14 TMEM63B CUL9 ENSG00000271754 VEGFA SLC35B2
GH06F043723 1.7 FANTOM5 Ensembl ENCODE 9.9 +533.0 532990 3.0 HDGF ARNT CREB3L1 MLX ARID4B FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 POLH ENSG00000271970 MAD2L1BP VEGFA GLTSCR1L MRPS18A RSPH9 GTPBP2 RPL24P4 CAPN11
GH06F043989 1.3 Ensembl ENCODE 10.1 +265.5 265537 6.3 HDGF PKNOX1 ARNT MLX ARID4B SLC30A9 FOS SP5 ZHX2 MXD4 CUL7 ENSG00000271970 RPS2P29 ENSG00000272223 RPL34P14 AARS2 LOC101929705 CUL9 MIR4647 SLC35B2
GH06F043713 1.3 Ensembl ENCODE 9.8 +542.3 542279 3.7 HDGF ATF1 WRNIP1 ARID4B ZNF48 ZNF121 GATA2 YY2 JUNB MXD4 ENSG00000223469 RPS2P28 RPL29P16 MRPS18A RSPH9 MAD2L1BP GTPBP2 NFKBIE MIR4647 SLC35B2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4647 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4647 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001880929 890 1601 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF143

Genomic Location for MIR4647 Gene

Chromosome:
6
Start:
44,254,096 bp from pter
End:
44,257,890 bp from pter
Size:
3,795 bases
Orientation:
Minus strand

Genomic View for MIR4647 Gene

Genes around MIR4647 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4647 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4647 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4647 Gene

Proteins for MIR4647 Gene

  • Protein details for MIR4647 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB61-S35B2_HUMAN
    Recommended name:
    Adenosine 3-phospho 5-phosphosulfate transporter 1
    Protein Accession:
    Q8TB61
    Secondary Accessions:
    • B4DDM2
    • B4DDU9
    • F5H7Y9
    • Q2VY06
    • Q53GA3
    • Q5T9W1
    • Q5T9W2
    • Q7Z2G3
    • Q8NBK6
    • Q96AR6

    Protein attributes for MIR4647 Gene

    Size:
    432 amino acids
    Molecular mass:
    47515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI20100.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR4647 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4647 Gene

Post-translational modifications for MIR4647 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR4647 Gene

No data available for DME Specific Peptides for MIR4647 Gene

Domains & Families for MIR4647 Gene

Gene Families for MIR4647 Gene

Protein Domains for MIR4647 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TB61

UniProtKB/Swiss-Prot:

S35B2_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with MIR4647: view

No data available for Suggested Antigen Peptide Sequences for MIR4647 Gene

Function for MIR4647 Gene

Molecular function for MIR4647 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 uM for PAPS {ECO:0000269 PubMed:12716889};
UniProtKB/Swiss-Prot Function:
Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.

Gene Ontology (GO) - Molecular Function for MIR4647 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP --
GO:0046964 3-phosphoadenosine 5-phosphosulfate transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with MIR4647: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4647 Gene

Localization for MIR4647 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4647 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR4647 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS --
GO:0030173 integral component of Golgi membrane IBA --
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with MIR4647: view

No data available for Subcellular locations from COMPARTMENTS for MIR4647 Gene

Pathways & Interactions for MIR4647 Gene

genes like me logo Genes that share pathways with MIR4647: view

Gene Ontology (GO) - Biological Process for MIR4647 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007165 signal transduction IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP --
GO:0046963 3-phosphoadenosine 5-phosphosulfate transport IDA --
GO:0050428 3-phosphoadenosine 5-phosphosulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with MIR4647: view

No data available for SIGNOR curated interactions for MIR4647 Gene

Transcripts for MIR4647 Gene

mRNA/cDNA for MIR4647 Gene

(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4647 Gene

No ASD Table

Relevant External Links for MIR4647 Gene

GeneLoc Exon Structure for
MIR4647
ECgene alternative splicing isoforms for
MIR4647

Expression for MIR4647 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4647 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4647 Gene:

MIR4647

mRNA Expression by UniProt/SwissProt for MIR4647 Gene:

Q8TB61-S35B2_HUMAN
Tissue specificity: Highly expressed in the placenta, pancreas, mammary gland and skeletal muscle. Weakly or not expressed in colon, heart and prostate.
genes like me logo Genes that share expression patterns with MIR4647: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4647 Gene

Orthologs for MIR4647 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR4647 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC35B2 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35b2 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PAPST1 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC35B2 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35B2 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35B2 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc35b2 35
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sll 35
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pst-1 35
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
Species where no ortholog for MIR4647 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4647 Gene

ENSEMBL:
Gene Tree for MIR4647 (if available)
TreeFam:
Gene Tree for MIR4647 (if available)

Paralogs for MIR4647 Gene

Paralogs for MIR4647 Gene

genes like me logo Genes that share paralogs with MIR4647: view

Variants for MIR4647 Gene

Sequence variations from dbSNP and Humsavar for MIR4647 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1059894 -- 44,254,762(-) GCCGT(C/T)TAAAG upstream-variant-2KB, reference, synonymous-codon
rs1063511 -- 44,253,827(+) ATTTT(C/T)TTCAT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1064730 -- 44,254,225(-) GCACC(A/C)CCACC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111408583 -- 44,254,424(+) AGTAA(C/G)TGGAA upstream-variant-2KB, utr-variant-3-prime
rs111429871 -- 44,254,427(+) AACTG(G/T)AACCT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4647 Gene

Variant ID Type Subtype PubMed ID
nsv603003 CNV gain 21841781
nsv5282 CNV insertion 18451855
nsv524398 CNV loss 19592680
nsv462936 CNV loss 19166990
dgv10641n54 CNV loss 21841781

Relevant External Links for MIR4647 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4647

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4647 Gene

Disorders for MIR4647 Gene

Relevant External Links for MIR4647

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4647

No disorders were found for MIR4647 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4647 Gene

Publications for MIR4647 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for MIR4647 Gene

Sources for MIR4647 Gene

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