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Aliases for MIR4646 Gene

Subcategory (RNA class) for MIR4646 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4646 Gene

  • MicroRNA 4646 2 3 5
  • Hsa-Mir-4646 3
  • Mir-4646 3

External Ids for MIR4646 Gene

Previous GeneCards Identifiers for MIR4646 Gene

  • GC06U902215
  • GC06M031672
  • GC06M031673
  • GC06M031702
  • GC06M031705
  • GC06M031715
  • GC06M031774
  • GC06M031826
  • GC06M031859
  • GC06M031894

Summaries for MIR4646 Gene

Entrez Gene Summary for MIR4646 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4646 Gene

MIR4646 (MicroRNA 4646) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4646 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4646 Gene

Genomics for MIR4646 Gene

GeneHancer (GH) Regulatory Elements for MIR4646 Gene

Promoters and enhancers for MIR4646 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031700 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.5 -1543 3.3 CLOCK MLX YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF263 SP3 ABHD16A MIR4646 DDX39B ATF6B SKIV2L LY6G5B LSM2 PBX2 MDC1 RPL3P2
GH06I031689 Enhancer 1.2 ENCODE dbSUPER 0.4 +10.6 10612 1.6 HDGF PKNOX1 SMAD1 ARNT POLR2B E2F8 ZNF143 FOS REST ZNF592 LOC105375018 LY6G5C SKIV2L LSM2 LY6G5B AGER ABHD16A MIR4646 ENSG00000204422
GH06I031694 Enhancer 0.3 dbSUPER 0.4 +5.9 5903 0.9 HDGF LY6G5C ABHD16A LOC105375018 MIR4646 ENSG00000204422
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4646 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4646 Gene

Genomic Locations for MIR4646 Gene
chr6:31,701,029-31,701,091
(GRCh38/hg38)
Size:
63 bases
Orientation:
Minus strand
chr6:31,668,806-31,668,868
(GRCh37/hg19)

Genomic View for MIR4646 Gene

Genes around MIR4646 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4646 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4646 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MIR4646 Gene

Post-translational modifications for MIR4646 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4646 Gene

Domains & Families for MIR4646 Gene

Gene Families for MIR4646 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4646: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4646 Gene

Function for MIR4646 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4646 Gene

Localization for MIR4646 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4646 Gene

Pathways & Interactions for MIR4646 Gene

SuperPathways for MIR4646 Gene

No Data Available

Interacting Proteins for MIR4646 Gene

Gene Ontology (GO) - Biological Process for MIR4646 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4646 Gene

Drugs & Compounds for MIR4646 Gene

No Compound Related Data Available

Transcripts for MIR4646 Gene

mRNA/cDNA for MIR4646 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4646 Gene

No ASD Table

Relevant External Links for MIR4646 Gene

GeneLoc Exon Structure for
MIR4646
ECgene alternative splicing isoforms for
MIR4646

Expression for MIR4646 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4646 Gene:

MIR4646
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4646 Gene

Orthologs for MIR4646 Gene

Evolution for MIR4646 Gene

ENSEMBL:
Gene Tree for MIR4646 (if available)
TreeFam:
Gene Tree for MIR4646 (if available)

No data available for Orthologs for MIR4646 Gene

Paralogs for MIR4646 Gene

No data available for Paralogs for MIR4646 Gene

Variants for MIR4646 Gene

Sequence variations from dbSNP and Humsavar for MIR4646 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001055964 -- 31,701,842(-) T/A upstream_transcript_variant
rs1001266566 -- 31,700,673(-) G/A downstream_transcript_variant
rs1004993098 -- 31,701,455(-) T/C upstream_transcript_variant
rs1007297150 -- 31,702,371(-) A/G upstream_transcript_variant
rs1008115128 -- 31,702,687(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4646 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv1161370 CNV deletion 26073780

Additional Variant Information for MIR4646 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4646

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4646 Gene

Disorders for MIR4646 Gene

Additional Disease Information for MIR4646

No disorders were found for MIR4646 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4646 Gene

Publications for MIR4646 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  4. A MIR4646 associated methylation locus is hypomethylated in adolescent depression. (PMID: 28618313) Boström AE … Schiöth HB (Journal of affective disorders 2017) 3

Products for MIR4646 Gene

Sources for MIR4646 Gene

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