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Aliases for MIR4645 Gene

Subcategory (RNA class) for MIR4645 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4645 Gene

  • MicroRNA 4645 2 3 5
  • Hsa-Mir-4645 3
  • Mir-4645 3

External Ids for MIR4645 Gene

Previous GeneCards Identifiers for MIR4645 Gene

  • GC06U902230
  • GC06M002865
  • GC06M002866
  • GC06M002868
  • GC06M002859
  • GC06M002861
  • GC06M002864
  • GC06M002870

Summaries for MIR4645 Gene

Entrez Gene Summary for MIR4645 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4645 Gene

MIR4645 (MicroRNA 4645) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4645 Gene

Genomics for MIR4645 Gene

Regulatory Elements for MIR4645 Gene

Enhancers for MIR4645 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F002852 1.5 FANTOM5 ENCODE 0.8 -2.1 -2053 8.0 HDGF PKNOX1 ARNT WRNIP1 ZFP64 SIN3A ARID4B FEZF1 DMAP1 YBX1 SERPINB9 RIPK1 SERPINB1 SERPINB9P1 HTATSF1P2 NQO2 MIR4645 PIR43328
GH06F002848 1.4 FANTOM5 ENCODE 0.8 +3.9 3852 3.7 HDGF TBP CBX3 PKNOX1 NFRKB ETS1 ZNF335 GATA2 CREM ZNF362 SERPINB9 SERPINB1 NQO2 ENSG00000232999 LINC01011 SERPINB6 WRNIP1 SERPINB9P1 RIPK1 MIR4645
GH06F002845 1.2 Ensembl ENCODE 0.4 +7.5 7534 1.7 HDGF PKNOX1 ATF1 ARNT ARID4B DMAP1 ZNF2 YY1 GTF3C2 ZNF766 SERPINB9 RIPK1 ENSG00000232999 LINC01011 NQO2 SERPINB6 WRNIP1 MYLK4 SERPINB1 MIR4645
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4645 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4645 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001877512 -93 401 HDGF PKNOX1 ZFP64 FEZF1 DMAP1 YBX1 ZNF2 YY1 ZNF207 FOS

Genomic Location for MIR4645 Gene

Chromosome:
6
Start:
2,854,031 bp from pter
End:
2,854,107 bp from pter
Size:
77 bases
Orientation:
Minus strand

Genomic View for MIR4645 Gene

Genes around MIR4645 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4645 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4645 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4645 Gene

ORGUL Member Location for MIR4645 Gene

ORGUL Member Location for MIR4645 gene

Proteins for MIR4645 Gene

Post-translational modifications for MIR4645 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4645 Gene

Domains & Families for MIR4645 Gene

Gene Families for MIR4645 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4645: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4645 Gene

Function for MIR4645 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4645 Gene

Localization for MIR4645 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4645 Gene

Pathways & Interactions for MIR4645 Gene

SuperPathways for MIR4645 Gene

No Data Available

Interacting Proteins for MIR4645 Gene

Gene Ontology (GO) - Biological Process for MIR4645 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4645 Gene

Transcripts for MIR4645 Gene

mRNA/cDNA for MIR4645 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4645 Gene

No ASD Table

Relevant External Links for MIR4645 Gene

GeneLoc Exon Structure for
MIR4645
ECgene alternative splicing isoforms for
MIR4645

Expression for MIR4645 Gene

mRNA expression in normal human tissues for MIR4645 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4645 Gene:

MIR4645
genes like me logo Genes that share expression patterns with MIR4645: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4645 Gene

Orthologs for MIR4645 Gene

Evolution for MIR4645 Gene

ENSEMBL:
Gene Tree for MIR4645 (if available)
TreeFam:
Gene Tree for MIR4645 (if available)

No data available for Orthologs for MIR4645 Gene

Paralogs for MIR4645 Gene

No data available for Paralogs for MIR4645 Gene

Variants for MIR4645 Gene

Sequence variations from dbSNP and Humsavar for MIR4645 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111304194 -- 2,853,629(+) TGGAG(-/C)CCCCC downstream-variant-500B
rs112210657 -- 2,854,555(+) GATAT(C/G)ACCAC intron-variant, upstream-variant-2KB
rs114537588 -- 2,854,353(+) TACCT(C/T)TGTAA intron-variant, upstream-variant-2KB
rs116315034 -- 2,854,063(+) GTCTC(G/T)TCGCA nc-transcript-variant
rs116627929 -- 2,855,193(+) TTGTT(C/T)GGGAG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4645 Gene

Variant ID Type Subtype PubMed ID
nsv830575 CNV loss 17160897

Relevant External Links for MIR4645 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4645

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4645 Gene

Disorders for MIR4645 Gene

Relevant External Links for MIR4645

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4645

No disorders were found for MIR4645 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4645 Gene

Publications for MIR4645 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4645 Gene

Sources for MIR4645 Gene

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