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Aliases for MIR4640 Gene

Subcategory (RNA class) for MIR4640 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4640 Gene

  • MicroRNA 4640 2 3
  • EC 2.7.10.1 4 61
  • Discoidin Domain Receptor Tyrosine Kinase 1 5
  • Epithelial Discoidin Domain Receptor 1 4
  • Discoidin Receptor Tyrosine Kinase 4
  • CD167 Antigen-Like Family Member A 4
  • Protein-Tyrosine Kinase RTK-6 4
  • Mammary Carcinoma Kinase 10 4
  • Tyrosine-Protein Kinase CAK 4
  • Protein-Tyrosine Kinase 3A 4
  • Cell Adhesion Kinase 4
  • Tyrosine Kinase DDR 4
  • CD167a Antigen 4
  • Hsa-Mir-4640 3
  • EC 2.7.10 61
  • MCK-10 4
  • EDDR1 4
  • NTRK4 4
  • PTK3A 4
  • TRK E 4
  • HGK2 4
  • RTK6 4
  • TRKE 4
  • DDR1 5
  • CAK 4
  • NEP 4

External Ids for MIR4640 Gene

Previous GeneCards Identifiers for MIR4640 Gene

  • GC06U902213
  • GC06P030862
  • GC06P030890

Summaries for MIR4640 Gene

Entrez Gene Summary for MIR4640 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4640 Gene

MIR4640 (MicroRNA 4640) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Non-integrin membrane-ECM interactions and Degradation of the extracellular matrix. An important paralog of this gene is DDR2.

UniProtKB/Swiss-Prot for MIR4640 Gene

  • Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4640 Gene

Genomics for MIR4640 Gene

Regulatory Elements for MIR4640 Gene

Enhancers for MIR4640 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F030816 1.5 FANTOM5 Ensembl ENCODE 12.1 -56.4 -56421 6.8 HDGF PKNOX1 ARNT MLX ARID4B SLC30A9 ZNF143 FOS KLF13 SP5 IER3 DDR1 HCG18 PRR3 RPP21 PPP1R10 HLA-E PPP1R18 FLOT1 LINC00243
GH06F030826 1.2 FANTOM5 ENCODE 12.1 -47.1 -47141 5.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 DDR1 VARS2 IER3 LINC00243 HLA-C DDR1-AS1 MIR4640 FLOT1 DPCR1 HCG21
GH06F030776 1.5 FANTOM5 Ensembl ENCODE 12.1 -93.1 -93121 13.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 IER3 PPP1R10 PAIP1P1 DHX16 LY6G5B GTF2H4 ABCF1 DDX39B VARS2 HCG18
GH06F030810 1.3 Ensembl ENCODE 12 -63.2 -63220 6.0 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DDR1 HCG18 IER3 GTF2H4 ABCF1 MICD DHX16 LINC00243 VARS2 DDX39B
GH06F030746 1.4 FANTOM5 Ensembl ENCODE 11.6 -125.0 -124994 9.5 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 IER3 GTF2H4 PPP1R10 DHX16 LY6G5B MICA PAIP1P1 DDX39B ABCF1 HLA-K
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4640 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4640 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001879707 1379 401 PKNOX1 SIN3A ARID4B ZNF2 YY1 ZNF143 DEK JUNB MXD4 REST

Genomic Location for MIR4640 Gene

Chromosome:
6
Start:
30,876,421 bp from pter
End:
30,900,156 bp from pter
Size:
23,736 bases
Orientation:
Plus strand

Genomic View for MIR4640 Gene

Genes around MIR4640 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4640 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4640 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MIR4640 Gene

  • Protein details for MIR4640 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08345-DDR1_HUMAN
    Recommended name:
    Epithelial discoidin domain-containing receptor 1
    Protein Accession:
    Q08345
    Secondary Accessions:
    • B5A975
    • B5A976
    • B7Z2K0
    • Q14196
    • Q16562
    • Q2L6H3
    • Q4LE50
    • Q5ST11
    • Q5ST12
    • Q6NSK4
    • Q9UD35
    • Q9UD36
    • Q9UD37
    • Q9UD86
    • Q9UDL2

    Protein attributes for MIR4640 Gene

    Size:
    913 amino acids
    Molecular mass:
    101128 Da
    Quaternary structure:
    • Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2.
    • Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2.
    SequenceCaution:
    • Sequence=ACF47649.1; Type=Erroneous termination; Positions=287; Note=Translated as Cys.; Evidence={ECO:0000305}; Sequence=BAE06103.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR4640 Gene

    Alternative splice isoforms for MIR4640 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4640 Gene

Post-translational modifications for MIR4640 Gene

  • Autophosphorylated in response to fibrillar collagen binding.
  • Glycosylation of Asn-211, but apparently not of Asn-260, Asn-371, or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.
  • Glycosylation at Asn 211, Asn 260, Asn 370, Asn 371, and Asn 394
  • Modification sites at PhosphoSitePlus

Domains & Families for MIR4640 Gene

Gene Families for MIR4640 Gene

Graphical View of Domain Structure for InterPro Entry

Q08345

UniProtKB/Swiss-Prot:

DDR1_HUMAN :
  • The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Domain:
  • The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.
  • Contains 1 F5/8 type C domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with MIR4640: view

No data available for Suggested Antigen Peptide Sequences for MIR4640 Gene

Function for MIR4640 Gene

Molecular function for MIR4640 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the multi-targeted cancer drugs imatinib and ponatinib.
UniProtKB/Swiss-Prot Function:
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Enzyme Numbers (IUBMB) for MIR4640 Gene

Gene Ontology (GO) - Molecular Function for MIR4640 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS --
GO:0005515 protein binding IPI --
GO:0005518 collagen binding IMP --
genes like me logo Genes that share ontologies with MIR4640: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4640 Gene

Localization for MIR4640 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4640 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.
Isoform 4: Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for MIR4640 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MIR4640: view

No data available for Subcellular locations from COMPARTMENTS for MIR4640 Gene

Pathways & Interactions for MIR4640 Gene

genes like me logo Genes that share pathways with MIR4640: view

Pathways by source for MIR4640 Gene

Gene Ontology (GO) - Biological Process for MIR4640 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001952 regulation of cell-matrix adhesion IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007155 cell adhesion TAS --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
genes like me logo Genes that share ontologies with MIR4640: view

No data available for SIGNOR curated interactions for MIR4640 Gene

Transcripts for MIR4640 Gene

mRNA/cDNA for MIR4640 Gene

(59) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4640 Gene

No ASD Table

Relevant External Links for MIR4640 Gene

GeneLoc Exon Structure for
MIR4640
ECgene alternative splicing isoforms for
MIR4640

Expression for MIR4640 Gene

mRNA expression in normal human tissues for MIR4640 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4640 Gene:

MIR4640

mRNA Expression by UniProt/SwissProt for MIR4640 Gene:

Q08345-DDR1_HUMAN
Tissue specificity: Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
genes like me logo Genes that share expression patterns with MIR4640: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4640 Gene

Orthologs for MIR4640 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4640 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDR1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDR1 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddr1 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDR1 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DDR1 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2H4 35
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DDR1 35
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ddr1 35
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ddr 35
  • 28 (a)
ManyToMany
CG34380 35
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ddr-2 35
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1149 35
  • 39 (a)
OneToMany
Species where no ortholog for MIR4640 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4640 Gene

ENSEMBL:
Gene Tree for MIR4640 (if available)
TreeFam:
Gene Tree for MIR4640 (if available)

Paralogs for MIR4640 Gene

Paralogs for MIR4640 Gene

genes like me logo Genes that share paralogs with MIR4640: view

Variants for MIR4640 Gene

Sequence variations from dbSNP and Humsavar for MIR4640 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1049621 -- 30,889,293(+) AACGA(C/G)TGCAC upstream-variant-2KB, reference, missense
rs1049622 -- 30,891,080(+) ATGAG(C/T)GTCTG downstream-variant-500B, reference, synonymous-codon
rs112048001 -- 30,889,416(+) AGGAC(C/T)GCTGG upstream-variant-2KB, reference, missense
rs1130681 -- 30,888,915(+) AAGTG(C/T)CGCTA upstream-variant-2KB, reference, synonymous-codon
rs113738680 -- 30,889,087(+) CCCTC(C/T)GCCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4640 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
esv3608518 CNV gain 21293372
nsv1031677 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv5245 CNV insertion 18451855
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Relevant External Links for MIR4640 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4640

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4640 Gene

Disorders for MIR4640 Gene

Relevant External Links for MIR4640

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4640

No disorders were found for MIR4640 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4640 Gene

Publications for MIR4640 Gene

  1. Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1). (PMID: 24509848) Fu H.L. … Fridman R. (J. Biol. Chem. 2014) 4 64
  2. Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. (PMID: 24768818) Canning P. … Bullock A.N. (J. Mol. Biol. 2014) 4 64
  3. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. (PMID: 23899692) Kim H.G. … Gray N.S. (ACS Chem. Biol. 2013) 4 64
  4. Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling. (PMID: 22483115) Carafoli F. … Hohenester E. (Structure 2012) 4 64
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64

Products for MIR4640 Gene

Sources for MIR4640 Gene

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