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Aliases for MIR4640 Gene

Subcategory (RNA class) for MIR4640 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4640 Gene

  • MicroRNA 4640 2 3 5
  • Hsa-Mir-4640 3

External Ids for MIR4640 Gene

Previous GeneCards Identifiers for MIR4640 Gene

  • GC06U902213
  • GC06P030862
  • GC06P031015

Summaries for MIR4640 Gene

Entrez Gene Summary for MIR4640 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4640 Gene

MIR4640 (MicroRNA 4640) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Non-integrin membrane-ECM interactions and Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway.

Additional gene information for MIR4640 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4640 Gene

Genomics for MIR4640 Gene

GeneHancer (GH) Regulatory Elements for MIR4640 Gene

Promoters and enhancers for MIR4640 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I030889 Enhancer 0.7 ENCODE dbSUPER 550.8 -0.8 -767 1.6 CTCF ZNF121 ZNF189 ZIC2 MIR4640 HLA-C VARS2 FLOT1 IER3 DPCR1 DDR1
GH06I030891 Enhancer 0.5 dbSUPER 550.8 +0.4 380 0.2 ZFHX2 EGR1 ZSCAN4 ZNF600 EGR2 MIR4640 IER3 FLOT1 DPCR1 DDR1 GC06P031581
GH06I030879 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.4 -6.5 -6500 9.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 FOS DDR1 VARS2 HLA-C PSORS1C1 GNL1 PSORS1C3 SFTA2 HCG18 IER3 FLOT1
GH06I030875 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -14.1 -14063 3.5 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B ZNF2 YY1 POLR2B ZNF766 DDR1 DDR1-AS1 VARS2 DDX39B LSM2 TRIM39 GTF2H4 PPP1R10 LY6G5B MDC1
GH06I030894 Enhancer 0.5 dbSUPER 0.8 +4.8 4804 3.2 POLR2A ZNF366 PHB2 YBX1 ZBTB17 VARS2 SFTA2 HLA-C ENSG00000252761 FLOT1 IER3 DPCR1 C6orf15 PSORS1C1 HCG21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4640 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4640 Gene

Genomic Locations for MIR4640 Gene
chr6:30,890,883-30,890,972
(GRCh38/hg38)
Size:
90 bases
Orientation:
Plus strand
chr6:30,858,660-30,858,749
(GRCh37/hg19)

Genomic View for MIR4640 Gene

Genes around MIR4640 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4640 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4640 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MIR4640 Gene

Post-translational modifications for MIR4640 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4640 Gene

Domains & Families for MIR4640 Gene

Gene Families for MIR4640 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4640: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4640 Gene

Function for MIR4640 Gene

Phenotypes From GWAS Catalog for MIR4640 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4640 Gene

Localization for MIR4640 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4640 Gene

Pathways & Interactions for MIR4640 Gene

genes like me logo Genes that share pathways with MIR4640: view

Pathways by source for MIR4640 Gene

Interacting Proteins for MIR4640 Gene

Gene Ontology (GO) - Biological Process for MIR4640 Gene

None

No data available for SIGNOR curated interactions for MIR4640 Gene

Drugs & Compounds for MIR4640 Gene

No Compound Related Data Available

Transcripts for MIR4640 Gene

mRNA/cDNA for MIR4640 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4640 Gene

No ASD Table

Relevant External Links for MIR4640 Gene

GeneLoc Exon Structure for
MIR4640
ECgene alternative splicing isoforms for
MIR4640

Expression for MIR4640 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4640 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4640 Gene:

MIR4640
genes like me logo Genes that share expression patterns with MIR4640: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4640 Gene

Orthologs for MIR4640 Gene

Evolution for MIR4640 Gene

ENSEMBL:
Gene Tree for MIR4640 (if available)
TreeFam:
Gene Tree for MIR4640 (if available)

No data available for Orthologs for MIR4640 Gene

Paralogs for MIR4640 Gene

No data available for Paralogs for MIR4640 Gene

Variants for MIR4640 Gene

Sequence variations from dbSNP and Humsavar for MIR4640 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000890964 -- 30,890,762(+) G/A upstream_transcript_variant
rs1001393100 -- 30,888,940(+) C/T upstream_transcript_variant
rs1002345889 -- 30,889,726(+) T/C upstream_transcript_variant
rs1003654033 -- 30,890,287(+) C/T upstream_transcript_variant
rs1004137285 -- 30,890,545(+) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4640 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
esv3608518 CNV gain 21293372
nsv1031677 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv5245 CNV insertion 18451855
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Additional Variant Information for MIR4640 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4640

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4640 Gene

Disorders for MIR4640 Gene

Additional Disease Information for MIR4640

No disorders were found for MIR4640 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4640 Gene

Publications for MIR4640 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4640 Gene

Sources for MIR4640 Gene

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