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Aliases for MIR455 Gene

Subcategory (RNA class) for MIR455 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR455 Gene

  • MicroRNA 455 2 3 5
  • Hsa-Mir-455 3
  • Mir-455 3
  • MIRN455 3

External Ids for MIR455 Gene

ORGUL Members for MIR455 Gene

Previous HGNC Symbols for MIR455 Gene

  • MIRN455

Previous GeneCards Identifiers for MIR455 Gene

  • GC09P116012
  • GC09P116971

Summaries for MIR455 Gene

Entrez Gene Summary for MIR455 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR455 Gene

MIR455 (MicroRNA 455) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR455 Gene

Genomics for MIR455 Gene

Regulatory Elements for MIR455 Gene

Enhancers for MIR455 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F114237 0.5 Ensembl ENCODE 12.5 +29.7 29654 3.2 HDAC1 ATF1 TBL1XR1 RAD21 YY1 GATA2 CREM SMARCA5 CEBPB REST MIR455 COL27A1 KIF12 LOC105376224
GH09F114246 0.6 ENCODE 12.5 +37.3 37306 0.8 MAFK MIR455 COL27A1 ATP6V1G1 LOC105376224
GH09F114180 0.8 Ensembl ENCODE 12.3 -28.1 -28052 2.4 ZBED1 EED JUNB HNF4G TCF7 ETV6 CREM COL27A1 MIR455 GC09P114173 GC09P114211 GC09P114261
GH09F114179 0.2 ENCODE 12.3 -30.3 -30259 0.1 HLF RAD21 MIR455 COL27A1 GC09P114173 GC09P114211 GC09P114261
GH09F114169 1.6 FANTOM5 Ensembl ENCODE 12.3 -35.7 -35675 9.5 MLX ARID4B DMAP1 YBX1 ZNF48 YY1 ZNF143 FOS SP5 NFYC COL27A1 MIR455 ORM1 GC09P114173 GC09P114211 GC09P114261
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR455 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR455 Gene

Chromosome:
9
Start:
114,209,434 bp from pter
End:
114,209,529 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR455 Gene

Genes around MIR455 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR455 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR455 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR455 Gene

Proteins for MIR455 Gene

Post-translational modifications for MIR455 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR455 Gene

Domains & Families for MIR455 Gene

Gene Families for MIR455 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR455: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR455 Gene

Function for MIR455 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR455 Gene

Localization for MIR455 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR455 Gene

Pathways & Interactions for MIR455 Gene

SuperPathways for MIR455 Gene

No Data Available

Interacting Proteins for MIR455 Gene

Gene Ontology (GO) - Biological Process for MIR455 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR455 Gene

Transcripts for MIR455 Gene

mRNA/cDNA for MIR455 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR455 Gene

No ASD Table

Relevant External Links for MIR455 Gene

GeneLoc Exon Structure for
MIR455
ECgene alternative splicing isoforms for
MIR455

Expression for MIR455 Gene

mRNA expression in normal human tissues for MIR455 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR455 Gene:

MIR455
genes like me logo Genes that share expression patterns with MIR455: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR455 Gene

Orthologs for MIR455 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR455 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-455 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-455 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-455 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-455 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir455 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-455 35
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-455 35
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-455b 35
  • 81 (a)
OneToOne
Species where no ortholog for MIR455 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR455 Gene

ENSEMBL:
Gene Tree for MIR455 (if available)
TreeFam:
Gene Tree for MIR455 (if available)

Paralogs for MIR455 Gene

No data available for Paralogs for MIR455 Gene

Variants for MIR455 Gene

Sequence variations from dbSNP and Humsavar for MIR455 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10982099 -- 114,207,541(+) TGCCT(C/G)CCAGG intron-variant, upstream-variant-2KB
rs10982100 -- 114,207,835(+) aTCTG(A/G)GAGAT intron-variant, upstream-variant-2KB
rs10982101 -- 114,207,881(+) TCAGA(C/T)TATGG intron-variant, upstream-variant-2KB
rs10982102 -- 114,208,123(+) ttacc(G/T)ctaca intron-variant, upstream-variant-2KB
rs10982103 -- 114,209,860(+) GGAGT(C/G)TGATA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR455 Gene

Variant ID Type Subtype PubMed ID
dgv12859n54 CNV gain 21841781
dgv33e196 CNV duplication 17116639
dgv7706n100 CNV gain 25217958
dgv948n27 CNV gain 19166990
esv2761285 CNV gain 21179565
esv3621549 CNV gain 21293372
nsv615233 CNV gain 21841781

Relevant External Links for MIR455 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR455

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR455 Gene

Disorders for MIR455 Gene

Relevant External Links for MIR455

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR455

No disorders were found for MIR455 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR455 Gene

Publications for MIR455 Gene

  1. MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase. (PMID: 25355599) Chai J. … Guo H. (Tumour Biol. 2015) 3 64
  2. Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. (PMID: 25686251) Shoshan E. … Bar-Eli M. (Nat. Cell Biol. 2015) 3 64
  3. Plasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm. (PMID: 25916817) Zhang W. … Liu C. (Clin. Biochem. 2015) 3 64
  4. miR455 is linked to hypoxia signaling and is deregulated in preeclampsia. (PMID: 25188518) LalevAce S. … BA1hler M. (Cell Death Dis 2014) 3 64
  5. Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma. (PMID: 23685355) Hudson J. … Chernock R.D. (Exp. Mol. Pathol. 2013) 3 64

Products for MIR455 Gene

Sources for MIR455 Gene

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