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Aliases for MIR4540 Gene

Subcategory (RNA class) for MIR4540 Gene


Quality Score for this RNA gene is


Aliases for MIR4540 Gene

  • MicroRNA 4540 2 3 5
  • Hsa-Mir-4540 3

External Ids for MIR4540 Gene

Previous GeneCards Identifiers for MIR4540 Gene

  • GC09U901722

Summaries for MIR4540 Gene

Entrez Gene Summary for MIR4540 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4540 Gene

MIR4540 (MicroRNA 4540) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4540 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4540 Gene

Genomics for MIR4540 Gene

Regulatory Elements for MIR4540 Gene

Enhancers for MIR4540 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H036868 0.9 ENCODE 0.7 -3.9 -3901 0.2 FOXA2 MLX ARID4B ZNF143 SP5 MXD4 MIER2 PPARG KAT8 NFIL3 MIR4540 MIR4476
GH09H036873 0.7 ENCODE 0.4 -9.2 -9151 0.2 SCRT1 CTCF ZNF654 TRIM22 REST EBF1 ZNF2 RAD21 HIC1 SCRT2 MIR4540 MIR4476
GH09H036869 0.5 FANTOM5 0.4 -5.3 -5284 0.2 HDGF ZNF366 YBX1 PAX5 ZCCHC7 MIR4540 MIR4476
GH09H036877 0.5 ENCODE 0.4 -13.4 -13408 0.6 EED EBF1 RUNX3 MIR4540 MIR4476
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4540 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4540 Gene

Genomic Locations for MIR4540 Gene
55 bases
Minus strand

Genomic View for MIR4540 Gene

Genes around MIR4540 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4540 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4540 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4540 Gene

ORGUL Member Location for MIR4540 Gene

ORGUL Member Location for MIR4540 gene

Proteins for MIR4540 Gene

Post-translational modifications for MIR4540 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4540 Gene

Domains & Families for MIR4540 Gene

Gene Families for MIR4540 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4540: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4540 Gene

Function for MIR4540 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4540 Gene

Localization for MIR4540 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4540 Gene

Pathways & Interactions for MIR4540 Gene

SuperPathways for MIR4540 Gene

No Data Available

Interacting Proteins for MIR4540 Gene

Gene Ontology (GO) - Biological Process for MIR4540 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4540 Gene

Drugs & Compounds for MIR4540 Gene

No Compound Related Data Available

Transcripts for MIR4540 Gene

mRNA/cDNA for MIR4540 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4540 Gene

No ASD Table

Relevant External Links for MIR4540 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4540 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4540 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4540 Gene

Orthologs for MIR4540 Gene

Evolution for MIR4540 Gene

Gene Tree for MIR4540 (if available)
Gene Tree for MIR4540 (if available)

No data available for Orthologs for MIR4540 Gene

Paralogs for MIR4540 Gene

No data available for Paralogs for MIR4540 Gene

Variants for MIR4540 Gene

Sequence variations from dbSNP and Humsavar for MIR4540 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1003779986 -- 36,865,798(+) TTTTG(G/T)AAGCC intron-variant, upstream-variant-2KB
rs1004588077 -- 36,865,633(+) GGAGA(C/T)CCCAC intron-variant, upstream-variant-2KB
rs1005177174 -- 36,864,552(+) CCAGC(C/T)GGACC intron-variant, upstream-variant-2KB
rs1006134713 -- 36,863,856(+) CTCCA(A/G)TCCCA intron-variant, downstream-variant-500B
rs1006177507 -- 36,865,408(+) CTCCT(A/C)GGTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4540 Gene

Variant ID Type Subtype PubMed ID
nsv6531 CNV deletion 18451855
nsv614212 CNV loss 21841781
nsv466387 CNV loss 19166990
nsv1125318 OTHER inversion 24896259

Relevant External Links for MIR4540 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4540 Gene

Disorders for MIR4540 Gene

Relevant External Links for MIR4540

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4540 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4540 Gene

Publications for MIR4540 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4540 Gene

Sources for MIR4540 Gene

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