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Aliases for MIR454 Gene

Subcategory (RNA class) for MIR454 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR454 Gene

  • MicroRNA 454 2 3 5
  • Hsa-Mir-454 3
  • Mir-454 3
  • MIRN454 3

External Ids for MIR454 Gene

Previous HGNC Symbols for MIR454 Gene

  • MIRN454

Previous GeneCards Identifiers for MIR454 Gene

  • GC17M054570
  • GC17M057215

Summaries for MIR454 Gene

Entrez Gene Summary for MIR454 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR454 Gene

MIR454 (MicroRNA 454) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR454 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR454

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR454 Gene

Genomics for MIR454 Gene

Regulatory Elements for MIR454 Gene

Enhancers for MIR454 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G059438 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -302.5 -302539 3.3 HDGF PKNOX1 FOXA2 MLX WRNIP1 SIN3A ARID4B DMAP1 YY1 SLC30A9 YPEL2 SMG8 MIR454 GC17P059454 ENSG00000266002
GH17G059092 1.4 Ensembl ENCODE dbSUPER 11 +43.7 43668 3.0 PKNOX1 INSM2 KLF17 SIN3A FEZF1 NFXL1 ZEB1 GATA2 ZNF366 ZSCAN5C RAD51C MIR454 SMG8 TEX14 ENSG00000224738 RN7SL716P
GH17G059219 1.1 ENCODE 10 -82.7 -82693 1.7 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 ZNF207 MIR454 RAD51C SKA2 GDPD1 GC17P059261
GH17G059110 0.6 dbSUPER 11.5 +25.8 25840 2.7 PKNOX1 ZNF362 PRDM6 ZNF157 ETV6 NFXL1 ZNF384 TRIM37 MIR301A MIR454 PRR11 SKA2 GC17M059110
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR454 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR454 Gene

Chromosome:
17
Start:
59,137,758 bp from pter
End:
59,137,872 bp from pter
Size:
115 bases
Orientation:
Minus strand

Genomic View for MIR454 Gene

Genes around MIR454 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR454 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR454 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR454 Gene

ORGUL Member Location for MIR454 Gene

ORGUL Member Location for MIR454 gene

Proteins for MIR454 Gene

Post-translational modifications for MIR454 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR454 Gene

Domains & Families for MIR454 Gene

Gene Families for MIR454 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR454: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR454 Gene

Function for MIR454 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR454 Gene

Localization for MIR454 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR454 Gene

Pathways & Interactions for MIR454 Gene

SuperPathways for MIR454 Gene

No Data Available

Interacting Proteins for MIR454 Gene

Gene Ontology (GO) - Biological Process for MIR454 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR454 Gene

Drugs & Compounds for MIR454 Gene

No Compound Related Data Available

Transcripts for MIR454 Gene

fRNAdb Secondary structures for MIR454 Gene

  • hsa-miR-454-3p_MIMAT0003885_Homo_sapiens_miR-454-3p_mature
  • FR399850

mRNA/cDNA for MIR454 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR454 Gene

No ASD Table

Relevant External Links for MIR454 Gene

GeneLoc Exon Structure for
MIR454
ECgene alternative splicing isoforms for
MIR454

Expression for MIR454 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR454 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR454 Gene:

MIR454
genes like me logo Genes that share expression patterns with MIR454: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR454 Gene

Orthologs for MIR454 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR454 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-454 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-454 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-454 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-454 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-454 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-454 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-454a 35
  • 61 (a)
OneToOne
Species where no ortholog for MIR454 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR454 Gene

ENSEMBL:
Gene Tree for MIR454 (if available)
TreeFam:
Gene Tree for MIR454 (if available)

Paralogs for MIR454 Gene

No data available for Paralogs for MIR454 Gene

Variants for MIR454 Gene

Sequence variations from dbSNP and Humsavar for MIR454 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000888218 -- 59,139,319(+) ATAAA(C/T)CTGGG intron-variant, upstream-variant-2KB
rs1001326032 -- 59,138,378(+) GATTT(G/T)GGAGC intron-variant, upstream-variant-2KB
rs1002732543 -- 59,139,633(+) GTGTC(A/T)GCCAC intron-variant, upstream-variant-2KB
rs1005065859 -- 59,139,796(+) ACATG(A/G)TTTCA intron-variant, upstream-variant-2KB
rs1005509184 -- 59,138,769(+) AAGGC(C/T)TTAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR454 Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
dgv3271n100 CNV gain 25217958
esv2758699 CNV gain 17122850
esv990139 CNV deletion 20482838
nsv1065063 CNV gain 25217958
nsv575802 CNV loss 21841781
nsv833499 CNV loss 17160897

Relevant External Links for MIR454 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR454

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR454 Gene

Disorders for MIR454 Gene

Relevant External Links for MIR454

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR454

No disorders were found for MIR454 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR454 Gene

Publications for MIR454 Gene

  1. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E. … Cuppen E. (Genome Res. 2006) 1 3 64
  2. MiR-454 promotes the progression of human non-small cell lung cancer and directly targets PTEN. (PMID: 27261580) Zhu D.Y. … Zhao S. (Biomed. Pharmacother. 2016) 3 64
  3. Involvement of miR-454 overexpression in the poor prognosis of hepatocellular carcinoma. (PMID: 27010136) Zhou L. … Yue Z.D. (Eur Rev Med Pharmacol Sci 2016) 3 64
  4. MicroRNA-454 regulates stromal cell derived factor-1 in the control of the growth of pancreatic ductal adenocarcinoma. (PMID: 26976451) Fan Y. … Cai D.F. (Sci Rep 2016) 3 64
  5. miR-454 functions as an oncogene by inhibiting CHD5 in hepatocellular carcinoma. (PMID: 26287602) Yu L. … Zhu L. (Oncotarget 2015) 3 64

Products for MIR454 Gene

Sources for MIR454 Gene

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