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Aliases for MIR454 Gene

Subcategory (RNA class) for MIR454 Gene


Quality Score for this RNA gene is


Aliases for MIR454 Gene

  • MicroRNA 454 2 3
  • Hsa-Mir-454 3
  • Mir-454 3
  • MIRN454 3

External Ids for MIR454 Gene

Previous HGNC Symbols for MIR454 Gene

  • MIRN454

Previous GeneCards Identifiers for MIR454 Gene

  • GC17M054570
  • GC17M057215

Summaries for MIR454 Gene

Entrez Gene Summary for MIR454 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR454 Gene

MIR454 (MicroRNA 454) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR454 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR454

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR454 Gene

Genomics for MIR454 Gene

Genomic Location for MIR454 Gene

59,137,758 bp from pter
59,137,872 bp from pter
115 bases
Minus strand

Genomic View for MIR454 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR454 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR454 Gene

ORGUL Member Location for MIR454 Gene

ORGUL Member Location for MIR454 gene

No data available for Regulatory Elements for MIR454 Gene

Proteins for MIR454 Gene

Post-translational modifications for MIR454 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR454 Gene

Domains & Families for MIR454 Gene

Gene Families for MIR454 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR454: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR454 Gene

Function for MIR454 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR454 Gene

Localization for MIR454 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR454 Gene

Pathways & Interactions for MIR454 Gene

SuperPathways for MIR454 Gene

No Data Available

Interacting Proteins for MIR454 Gene

Gene Ontology (GO) - Biological Process for MIR454 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR454 Gene

Drugs & Compounds for MIR454 Gene

No Compound Related Data Available

Transcripts for MIR454 Gene

fRNAdb Secondary structures for MIR454 Gene

  • hsa-miR-454-3p_MIMAT0003885_Homo_sapiens_miR-454-3p_mature
  • FR399850

mRNA/cDNA for MIR454 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR454 Gene

No ASD Table

Relevant External Links for MIR454 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR454 Gene

mRNA expression in normal human tissues for MIR454 Gene

genes like me logo Genes that share expression patterns with MIR454: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR454 Gene

Orthologs for MIR454 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR454 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-454 36
  • 95 (a)
(Canis familiaris)
Mammalia cfa-mir-454 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-454 36
  • 89 (a)
(Pan troglodytes)
Mammalia ptr-mir-454 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-454 36
  • 51 (a)
(Anolis carolinensis)
Reptilia aca-mir-454 36
  • 64 (a)
(Danio rerio)
Actinopterygii dre-mir-454a 36
  • 61 (a)
Species with no ortholog for MIR454:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR454 Gene

Gene Tree for MIR454 (if available)
Gene Tree for MIR454 (if available)

Paralogs for MIR454 Gene

No data available for Paralogs for MIR454 Gene

Variants for MIR454 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR454 Gene

Variant ID Type Subtype PubMed ID
dgv3236n71 CNV Loss 21882294
nsv908644 CNV Loss 21882294
nsv908646 CNV Loss 21882294
nsv833499 CNV Loss 17160897
dgv995e1 CNV Complex 17122850
dgv3237n71 CNV Loss 21882294
esv990139 CNV Deletion 20482838

Relevant External Links for MIR454 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR454 Gene

Disorders for MIR454 Gene

Relevant External Links for MIR454

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR454: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR454 Gene

Publications for MIR454 Gene

  1. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E. … Cuppen E. (Genome Res. 2006) 1 67
  2. Signature of circulating microRNAs in osteoarthritis. (PMID: 24515954) Beyer C. … Kiechl S. (Ann. Rheum. Dis. 2015) 67
  3. miR-454 is down-regulated in osteosarcomas and suppresses cell proliferation and invasion by directly targeting c-Met. (PMID: 25880599) Niu G. … Sun L. (Cell Prolif. 2015) 67
  4. Expression of microRNA-454 in TGF-I^1-stimulated hepatic stellate cells and in mouse livers infected with Schistosoma japonicum. (PMID: 24685242) Zhu D. … Zhang L. (Parasit Vectors 2014) 67
  5. Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells. (PMID: 25115181) Wu X. … Wang J. (Radiat Oncol 2014) 67

Products for MIR454 Gene

Sources for MIR454 Gene

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