Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4531 Gene

Subcategory (RNA class) for MIR4531 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4531 Gene

  • MicroRNA 4531 2 3 5
  • Hsa-Mir-4531 3

External Ids for MIR4531 Gene

Previous GeneCards Identifiers for MIR4531 Gene

  • GC19U901538
  • GC19M045157

Summaries for MIR4531 Gene

Entrez Gene Summary for MIR4531 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4531 Gene

MIR4531 (MicroRNA 4531) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4531 Gene

Genomics for MIR4531 Gene

Regulatory Elements for MIR4531 Gene

Enhancers for MIR4531 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F044647 1.1 Ensembl ENCODE 0.8 +5.0 4957 3.1 CTCF ESRRA USF1 CBX3 SAP130 ZIC2 ZNF664 ZFHX2 ZBTB48 POLR2A PVR CEACAM19 CEACAM22P MIR4531
GH19F044657 0.9 ENCODE 0.8 -3.8 -3764 0.7 HDGF PKNOX1 ARID4B SIN3A RAD21 EGR1 ZNF143 CREM EGR2 USF2 PVR CEACAM19 MIR4531
GH19F044653 0.8 ENCODE 0.8 -0.6 -561 1.5 CTCF PKNOX1 USF1 ZMYM3 SIN3A EBF1 RAD21 ZNF239 ZNF143 SMC3 PVR CEACAM19 MIR4531
GH19F044646 0.6 ENCODE 0.4 +7.4 7399 0.4 BCOR ZFP69B ZNF263 ZNF692 ZMYM3 ZBTB33 KDM1A CEACAM19 PVR MIR4531
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4531 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4531 Gene

Chromosome:
19
Start:
44,653,686 bp from pter
End:
44,653,732 bp from pter
Size:
47 bases
Orientation:
Minus strand

Genomic View for MIR4531 Gene

Genes around MIR4531 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4531 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4531 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4531 Gene

Proteins for MIR4531 Gene

Post-translational modifications for MIR4531 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4531 Gene

Domains & Families for MIR4531 Gene

Gene Families for MIR4531 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4531: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4531 Gene

Function for MIR4531 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4531 Gene

Localization for MIR4531 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4531 Gene

Pathways & Interactions for MIR4531 Gene

SuperPathways for MIR4531 Gene

No Data Available

Interacting Proteins for MIR4531 Gene

Gene Ontology (GO) - Biological Process for MIR4531 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4531 Gene

Transcripts for MIR4531 Gene

mRNA/cDNA for MIR4531 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4531 Gene

No ASD Table

Relevant External Links for MIR4531 Gene

GeneLoc Exon Structure for
MIR4531
ECgene alternative splicing isoforms for
MIR4531

Expression for MIR4531 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4531 Gene:

MIR4531
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4531 Gene

Orthologs for MIR4531 Gene

Evolution for MIR4531 Gene

ENSEMBL:
Gene Tree for MIR4531 (if available)
TreeFam:
Gene Tree for MIR4531 (if available)

No data available for Orthologs for MIR4531 Gene

Paralogs for MIR4531 Gene

No data available for Paralogs for MIR4531 Gene

Variants for MIR4531 Gene

Sequence variations from dbSNP and Humsavar for MIR4531 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10406264 -- 44,653,790(+) CTCCC(A/G/T)CTGTT intron-variant, upstream-variant-2KB
rs10425860 -- 44,653,336(+) TCCCT(C/T)AGGTA intron-variant, downstream-variant-500B
rs10469291 -- 44,653,569(+) CACTG(C/T)TGTGT intron-variant, downstream-variant-500B
rs111729675 -- 44,653,845(+) GCGTA(C/G)CCCAG intron-variant, upstream-variant-2KB
rs112177685 -- 44,654,114(+) GGGAG(A/G)AGGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4531 Gene

Variant ID Type Subtype PubMed ID
nsv483005 CNV loss 15286789
nsv1062812 CNV gain 25217958

Relevant External Links for MIR4531 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4531

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4531 Gene

Disorders for MIR4531 Gene

Relevant External Links for MIR4531

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4531

No disorders were found for MIR4531 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4531 Gene

Publications for MIR4531 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4531 Gene

Sources for MIR4531 Gene

Content
Loading form....