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Aliases for MIR4525 Gene

Subcategory (RNA class) for MIR4525 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4525 Gene

  • MicroRNA 4525 2 3 5
  • Hsa-Mir-4525 3

External Ids for MIR4525 Gene

Previous GeneCards Identifiers for MIR4525 Gene

  • GC17U901644
  • GC17M080628

Summaries for MIR4525 Gene

Entrez Gene Summary for MIR4525 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4525 Gene

MIR4525 (MicroRNA 4525) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4525 Gene

Genomics for MIR4525 Gene

Regulatory Elements for MIR4525 Gene

Enhancers for MIR4525 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G082668 1.4 Ensembl ENCODE dbSUPER 0.7 -0.4 -366 1.1 ELF3 HDGF RB1 ARID4B SIN3A DNMT3B ZNF48 ZSCAN9 RAD21 SLC30A9 WDR45B FN3K LOC101929552 LOC105371942 ENSG00000261888 MIR4525 GC17M082673
GH17G082671 1.2 ENCODE dbSUPER 0.7 -2.9 -2853 0.2 FOXA2 ATF1 ARNT ZNF473 ZNF493 ZSCAN4 ZNF195 DMAP1 YBX1 PLRG1 ENSG00000262049 ENSG00000265678 GPS1 ENSG00000262410 WDR45B NARF-IT1 ENSG00000263321 LOC105376790 FN3K ENSG00000262652
GH17G082672 0.8 dbSUPER 0.7 -4.2 -4160 0.9 FOXA2 ZNF473 ZSCAN4 DMAP1 YBX1 ZNF48 TCF12 CREM THAP11 CEBPB WDR45B ENSG00000263321 FN3K LOC101929552 MIR4525 GC17M082673
GH17G082661 0.8 dbSUPER 0.7 +4.6 4591 4.0 CTCF KLF1 ZIC2 GATA3 ZFHX2 ZNF316 GATA2 SCRT2 FOS FOSL2 FN3K FN3KRP WDR45B LOC105371942 LOC101929552 MIR4525 GC17P082655
GH17G082669 0.6 ENCODE dbSUPER 0.7 -1.7 -1721 1.0 NR2F2 WDR45B FN3K LOC101929552 FN3KRP ENSG00000262663 MIR4525 GC17M082673
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4525 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4525 Gene

Chromosome:
17
Start:
82,668,233 bp from pter
End:
82,668,307 bp from pter
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR4525 Gene

Genes around MIR4525 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4525 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4525 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4525 Gene

ORGUL Member Location for MIR4525 Gene

ORGUL Member Location for MIR4525 gene

Proteins for MIR4525 Gene

Post-translational modifications for MIR4525 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4525 Gene

Domains & Families for MIR4525 Gene

Gene Families for MIR4525 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4525: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4525 Gene

Function for MIR4525 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4525 Gene

Localization for MIR4525 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4525 Gene

Pathways & Interactions for MIR4525 Gene

SuperPathways for MIR4525 Gene

No Data Available

Interacting Proteins for MIR4525 Gene

Gene Ontology (GO) - Biological Process for MIR4525 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4525 Gene

Drugs & Compounds for MIR4525 Gene

No Compound Related Data Available

Transcripts for MIR4525 Gene

mRNA/cDNA for MIR4525 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4525 Gene

No ASD Table

Relevant External Links for MIR4525 Gene

GeneLoc Exon Structure for
MIR4525
ECgene alternative splicing isoforms for
MIR4525

Expression for MIR4525 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4525 Gene:

MIR4525
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4525 Gene

Orthologs for MIR4525 Gene

Evolution for MIR4525 Gene

ENSEMBL:
Gene Tree for MIR4525 (if available)
TreeFam:
Gene Tree for MIR4525 (if available)

No data available for Orthologs for MIR4525 Gene

Paralogs for MIR4525 Gene

No data available for Paralogs for MIR4525 Gene

Variants for MIR4525 Gene

Sequence variations from dbSNP and Humsavar for MIR4525 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000334606 -- 82,669,177(+) TACAA(A/C)AAATT intron-variant, upstream-variant-2KB
rs1002580334 -- 82,668,350(+) CAGCC(C/G/T)GGGCC intron-variant, upstream-variant-2KB
rs1003670286 -- 82,669,995(+) TGGGA(A/G)TCTAT intron-variant, upstream-variant-2KB
rs1004184859 -- 82,668,828(+) TGATC(C/T)GTGGA intron-variant, upstream-variant-2KB
rs1004299646 -- 82,668,660(+) GGAGC(A/G)GGCGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4525 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2762577 CNV gain+loss 21179565
nsv1062980 CNV gain 25217958
nsv1067362 CNV gain 25217958
nsv1067553 CNV loss 25217958
nsv428351 CNV gain 18775914
nsv509680 CNV insertion 20534489
nsv833575 CNV loss 17160897
nsv952395 CNV deletion 24416366

Relevant External Links for MIR4525 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4525

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4525 Gene

Disorders for MIR4525 Gene

Relevant External Links for MIR4525

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4525

No disorders were found for MIR4525 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4525 Gene

Publications for MIR4525 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4525 Gene

Sources for MIR4525 Gene

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