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Aliases for MIR4525 Gene

Subcategory (RNA class) for MIR4525 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4525 Gene

  • MicroRNA 4525 2 3 5
  • Hsa-Mir-4525 3

External Ids for MIR4525 Gene

Previous GeneCards Identifiers for MIR4525 Gene

  • GC17U901644
  • GC17M080628

Summaries for MIR4525 Gene

Entrez Gene Summary for MIR4525 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4525 Gene

MIR4525 (MicroRNA 4525) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4525 Gene

Genomics for MIR4525 Gene

Regulatory Elements for MIR4525 Gene

Enhancers for MIR4525 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F082668 1 Ensembl ENCODE 0.8 -0.4 -366 1.1 ELF3 ARID4B SIN3A ZNF48 ZSCAN9 DNMT3B RAD21 SLC30A9 ZNF143 EGR2 WDR45B FN3K LOC101929552 LOC105371942 ENSG00000261888 MIR4525 GC17M082673
GH17F082671 0.2 ENCODE 0.8 -2.9 -2853 0.2 ATF1 ZNF493 DMAP1 YBX1 PLRG1 ZNF207 KLF7 ZNF645 SSRP1 KLF16 ENSG00000262049 WDR45B NARF-IT1 FN3K ENSG00000262652 HGS ARL2BPP9 ALYREF ENSG00000265678 OGFOD3
GH17F082669 0.6 ENCODE 0.8 -1.7 -1721 1.0 NR2F2 WDR45B FN3K LOC101929552 FN3KRP ENSG00000262663 MIR4525 GC17M082673
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4525 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4525 Gene

Chromosome:
17
Start:
82,668,233 bp from pter
End:
82,668,307 bp from pter
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR4525 Gene

Genes around MIR4525 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4525 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4525 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4525 Gene

ORGUL Member Location for MIR4525 Gene

ORGUL Member Location for MIR4525 gene

Proteins for MIR4525 Gene

Post-translational modifications for MIR4525 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4525 Gene

Domains & Families for MIR4525 Gene

Gene Families for MIR4525 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4525: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4525 Gene

Function for MIR4525 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4525 Gene

Localization for MIR4525 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4525 Gene

Pathways & Interactions for MIR4525 Gene

SuperPathways for MIR4525 Gene

No Data Available

Interacting Proteins for MIR4525 Gene

Gene Ontology (GO) - Biological Process for MIR4525 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4525 Gene

Transcripts for MIR4525 Gene

mRNA/cDNA for MIR4525 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4525 Gene

No ASD Table

Relevant External Links for MIR4525 Gene

GeneLoc Exon Structure for
MIR4525
ECgene alternative splicing isoforms for
MIR4525

Expression for MIR4525 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4525 Gene:

MIR4525
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4525 Gene

Orthologs for MIR4525 Gene

Evolution for MIR4525 Gene

ENSEMBL:
Gene Tree for MIR4525 (if available)
TreeFam:
Gene Tree for MIR4525 (if available)

No data available for Orthologs for MIR4525 Gene

Paralogs for MIR4525 Gene

No data available for Paralogs for MIR4525 Gene

Variants for MIR4525 Gene

Sequence variations from dbSNP and Humsavar for MIR4525 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10710873 -- 82,669,136(+) AATTC(-/G)AAACC intron-variant, upstream-variant-2KB
rs111724693 -- 82,667,761(+) AGAAC(A/G)CCCGA intron-variant, downstream-variant-500B
rs111835757 -- 82,667,942(+) CTGAC(A/G)GGGCA intron-variant, downstream-variant-500B, utr-variant-5-prime
rs114335069 -- 82,669,118(+) GGATC(A/G)CTTGA intron-variant, upstream-variant-2KB
rs114598293 -- 82,670,010(+) GAATG(C/T)GGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4525 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2762577 CNV gain+loss 21179565
nsv1062980 CNV gain 25217958
nsv1067362 CNV gain 25217958
nsv1067553 CNV loss 25217958
nsv428351 CNV gain 18775914
nsv509680 CNV insertion 20534489
nsv833575 CNV loss 17160897
nsv952395 CNV deletion 24416366

Relevant External Links for MIR4525 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4525

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4525 Gene

Disorders for MIR4525 Gene

Relevant External Links for MIR4525

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4525

No disorders were found for MIR4525 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4525 Gene

Publications for MIR4525 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4525 Gene

Sources for MIR4525 Gene

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