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Aliases for MIR4524A Gene

Subcategory (RNA class) for MIR4524A Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4524A Gene

  • MicroRNA 4524a 2 3 5
  • MicroRNA 4524 2 3
  • Hsa-Mir-4524a 3
  • Hsa-Mir-4524 3
  • Mir-4524a 3
  • MIR4524 3

External Ids for MIR4524A Gene

Previous HGNC Symbols for MIR4524A Gene

  • MIR4524

Previous GeneCards Identifiers for MIR4524A Gene

  • GC17U901689
  • GC17P067099
  • GC17M067098

Summaries for MIR4524A Gene

Entrez Gene Summary for MIR4524A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4524A Gene

MIR4524A (MicroRNA 4524a) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4524A Gene

Genomics for MIR4524A Gene

Regulatory Elements for MIR4524A Gene

Enhancers for MIR4524A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F069103 0.9 ENCODE 0.8 -4.1 -4103 0.2 HDAC1 PKNOX1 CBX3 ATF1 TBL1XR1 GATA2 CREM ZBTB2 NCOA1 ZEB2 ABCA6 ABCA9 ABCA10 MIR4524A GC17M069120
GH17F069099 0.6 FANTOM5 0.8 -0.1 -70 0.1 FOSL1 ZGPAT ATF3 CEBPG ABCA6 ABCA9 ABCA10 MIR4524A GC17M069120
GH17F069115 1.1 Ensembl ENCODE 0.3 -16.4 -16388 1.4 HDGF TBP CEBPG EBF1 RAD21 YY1 RELA ARID3A MTA3 POLR2A ABCA10 ABCA6 ABCA9 ABCA5 MIR4524A GC17M069120
GH17F069118 0.7 Ensembl 0.3 -18.7 -18669 0.6 TBP TBL1XR1 MTA2 CHD1 JUNB BMI1 EP300 RELA POLR2A IKZF1 ABCA6 ABCA10 ABCA9 GC17M069120 MIR4524A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4524A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4524A Gene

Chromosome:
17
Start:
69,099,564 bp from pter
End:
69,099,632 bp from pter
Size:
69 bases
Orientation:
Minus strand

Genomic View for MIR4524A Gene

Genes around MIR4524A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4524A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4524A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4524A Gene

ORGUL Member Location for MIR4524A Gene

ORGUL Member Location for MIR4524A gene

Proteins for MIR4524A Gene

Post-translational modifications for MIR4524A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4524A Gene

Domains & Families for MIR4524A Gene

Gene Families for MIR4524A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4524A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4524A Gene

Function for MIR4524A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4524A Gene

Localization for MIR4524A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4524A Gene

Pathways & Interactions for MIR4524A Gene

SuperPathways for MIR4524A Gene

No Data Available

Interacting Proteins for MIR4524A Gene

Gene Ontology (GO) - Biological Process for MIR4524A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4524A Gene

Transcripts for MIR4524A Gene

mRNA/cDNA for MIR4524A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4524A Gene

No ASD Table

Relevant External Links for MIR4524A Gene

GeneLoc Exon Structure for
MIR4524A
ECgene alternative splicing isoforms for
MIR4524A

Expression for MIR4524A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4524A Gene:

MIR4524A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4524A Gene

Orthologs for MIR4524A Gene

Evolution for MIR4524A Gene

ENSEMBL:
Gene Tree for MIR4524A (if available)
TreeFam:
Gene Tree for MIR4524A (if available)

No data available for Orthologs for MIR4524A Gene

Paralogs for MIR4524A Gene

No data available for Paralogs for MIR4524A Gene

Variants for MIR4524A Gene

Sequence variations from dbSNP and Humsavar for MIR4524A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10581075 -- 69,100,353(+) TAAAT(-/AAA)TCAAC intron-variant, upstream-variant-2KB
rs10713615 -- 69,100,632(+) GCAGG(-/A)AAAAA intron-variant, upstream-variant-2KB
rs111760217 -- 69,100,686(+) AAAAT(A/T)ATAAT intron-variant, upstream-variant-2KB
rs112641777 -- 69,100,877(+) ATTCA(C/T)AAGAA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs11382456 -- 69,099,948(+) CATTT(-/C)CTAAT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4524A Gene

Variant ID Type Subtype PubMed ID
nsv833526 CNV gain 17160897
nsv470598 CNV loss 18288195

Relevant External Links for MIR4524A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4524A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4524A Gene

Disorders for MIR4524A Gene

Relevant External Links for MIR4524A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4524A

No disorders were found for MIR4524A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4524A Gene

Publications for MIR4524A Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) FriedlAonder M.R. … Rajewsky N. (Nucleic Acids Res. 2012) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  4. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. (PMID: 21807764) Joyce C.E. … Bowcock A.M. (Hum. Mol. Genet. 2011) 3 64
  5. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64

Products for MIR4524A Gene

Sources for MIR4524A Gene

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