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Aliases for MIR4521 Gene

Subcategory (RNA class) for MIR4521 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4521 Gene

  • MicroRNA 4521 2 3 5
  • Hsa-Mir-4521 3
  • Mir-4521 3

External Ids for MIR4521 Gene

Previous GeneCards Identifiers for MIR4521 Gene

  • GC17U901651
  • GC17P008116
  • GC17P008121
  • GC17P008187
  • GC17P008198
  • GC17P008202
  • GC17P008207
  • GC17P008216

Summaries for MIR4521 Gene

Entrez Gene Summary for MIR4521 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4521 Gene

MIR4521 (MicroRNA 4521) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4521 Gene

Genomics for MIR4521 Gene

Regulatory Elements for MIR4521 Gene


Promoters for MIR4521 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000282326 -245 2601 MLX CREB3L1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 SSRP1

Genomic Location for MIR4521 Gene

Chromosome:
17
Start:
8,186,945 bp from pter
End:
8,187,004 bp from pter
Size:
60 bases
Orientation:
Plus strand

Genomic View for MIR4521 Gene

Genes around MIR4521 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4521 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4521 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4521 Gene

Proteins for MIR4521 Gene

Post-translational modifications for MIR4521 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4521 Gene

Domains & Families for MIR4521 Gene

Gene Families for MIR4521 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4521: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4521 Gene

Function for MIR4521 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4521 Gene

Localization for MIR4521 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4521 Gene

Pathways & Interactions for MIR4521 Gene

SuperPathways for MIR4521 Gene

No Data Available

Interacting Proteins for MIR4521 Gene

Gene Ontology (GO) - Biological Process for MIR4521 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4521 Gene

Drugs & Compounds for MIR4521 Gene

No Compound Related Data Available

Transcripts for MIR4521 Gene

mRNA/cDNA for MIR4521 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4521 Gene

No ASD Table

Relevant External Links for MIR4521 Gene

GeneLoc Exon Structure for
MIR4521
ECgene alternative splicing isoforms for
MIR4521

Expression for MIR4521 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4521 Gene:

MIR4521
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4521 Gene

Orthologs for MIR4521 Gene

Evolution for MIR4521 Gene

ENSEMBL:
Gene Tree for MIR4521 (if available)
TreeFam:
Gene Tree for MIR4521 (if available)

No data available for Orthologs for MIR4521 Gene

Paralogs for MIR4521 Gene

No data available for Paralogs for MIR4521 Gene

Variants for MIR4521 Gene

Sequence variations from dbSNP and Humsavar for MIR4521 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000408031 -- 8,186,373(+) CGCAA(A/C/T)GGTAG upstream-variant-2KB
rs1001835692 -- 8,186,213(+) ACAGG(G/T)CTGGC upstream-variant-2KB
rs1002418991 -- 8,187,235(+) GCCTC(C/T)GTGTT downstream-variant-500B
rs1002468861 -- 8,187,231(+) CGGTG(C/T)CTCCG downstream-variant-500B
rs1004323842 -- 8,185,894(+) GTGGG(G/T)ACATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4521 Gene

Variant ID Type Subtype PubMed ID
nsv527475 CNV loss 19592680
nsv833352 CNV loss 17160897
nsv833353 CNV loss 17160897

Relevant External Links for MIR4521 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4521

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4521 Gene

Disorders for MIR4521 Gene

Relevant External Links for MIR4521

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4521

No disorders were found for MIR4521 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4521 Gene

Publications for MIR4521 Gene

  1. Serum MicroRNA-4521 is a Potential Biomarker for Focal Cortical Dysplasia with Refractory Epilepsy. (PMID: 26645999) Wang X. … Yin J. (Neurochem. Res. 2016) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4521 Gene

Sources for MIR4521 Gene

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