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Aliases for MIR4521 Gene

Subcategory (RNA class) for MIR4521 Gene

miRNA

Quality Score for this RNA gene is

2

Aliases for MIR4521 Gene

  • MicroRNA 4521 2 3
  • Hsa-Mir-4521 3

External Ids for MIR4521 Gene

Previous GeneCards Identifiers for MIR4521 Gene

  • GC17U901651
  • GC17P008116
  • GC17P008121

Summaries for MIR4521 Gene

Entrez Gene Summary for MIR4521 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4521 Gene

MIR4521 (MicroRNA 4521) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4521 Gene

Genomics for MIR4521 Gene

Genomic Location for MIR4521 Gene

Start:
8,186,945 bp from pter
End:
8,187,004 bp from pter
Size:
60 bases
Orientation:
Plus strand

Genomic View for MIR4521 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR4521 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4521 Gene

No data available for Regulatory Elements for MIR4521 Gene

Proteins for MIR4521 Gene

Post-translational modifications for MIR4521 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4521 Gene

Domains for MIR4521 Gene

Gene Families for MIR4521 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4521: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4521 Gene

Function for MIR4521 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR4521 Gene

Localization for MIR4521 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4521 Gene

Pathways for MIR4521 Gene

SuperPathways for MIR4521 Gene

No Data Available

Interacting Proteins for MIR4521 Gene

Gene Ontology (GO) - Biological Process for MIR4521 Gene

None

No data available for Pathways by source for MIR4521 Gene

Transcripts for MIR4521 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4521 Gene

No ASD Table

Relevant External Links for MIR4521 Gene

GeneLoc Exon Structure for
MIR4521
ECgene alternative splicing isoforms for
MIR4521

No data available for mRNA/cDNA for MIR4521 Gene

Expression for MIR4521 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR4521 Gene

Orthologs for MIR4521 Gene

No data available for Orthologs and Evolution for MIR4521 Gene

Paralogs for MIR4521 Gene

No data available for Paralogs for MIR4521 Gene

Variants for MIR4521 Gene

Sequence variations from dbSNP and Humsavar for MIR4521 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs894508 -- 8,186,310(+) CCTCC(A/T)GGGCG upstream-variant-2KB
rs3027262 -- 8,186,345(+) GCTGC(C/T)GAGTG upstream-variant-2KB
rs3027263 -- 8,186,765(+) TCCAA(A/C)TGTGC upstream-variant-2KB
rs3027264 -- 8,186,784(+) CGACG(C/T)AGGCG upstream-variant-2KB
rs3027265 -- 8,186,990(+) ACTAG(G/T)ATTTC nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4521 Gene

Variant ID Type Subtype PubMed ID
nsv833352 CNV Loss 17160897
nsv907658 CNV Loss 21882294
nsv527475 CNV Loss 19592680
nsv833353 CNV Loss 17160897

Relevant External Links for MIR4521 Gene

HapMap Linkage Disequilibrium report
MIR4521

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR4521 Gene

Disorders for MIR4521 Gene

No disorders were found for MIR4521 Gene.

No data available for UniProtKB/Swiss-Prot for MIR4521 Gene

Publications for MIR4521 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3

Products for MIR4521 Gene

Sources for MIR4521 Gene

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