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Aliases for MIR452 Gene

Subcategory (RNA class) for MIR452 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR452 Gene

  • MicroRNA 452 2 3
  • GABRE 4 5
  • Gamma-Aminobutyric Acid Type A Receptor Epsilon Subunit 5
  • GABA(A) Receptor Subunit Epsilon 4
  • Hsa-Mir-452 3
  • Mir-452 3
  • MIRN452 3

External Ids for MIR452 Gene

Previous HGNC Symbols for MIR452 Gene

  • MIRN452

Previous GeneCards Identifiers for MIR452 Gene

  • GC0XM150878
  • GC0XM151128

Summaries for MIR452 Gene

Entrez Gene Summary for MIR452 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR452 Gene

MIR452 (MicroRNA 452) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is GABRG3.

UniProtKB/Swiss-Prot for MIR452 Gene

  • GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR452 Gene

Genomics for MIR452 Gene

Regulatory Elements for MIR452 Gene

Enhancers for MIR452 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR452 on UCSC Golden Path with GeneCards custom track

Promoters for MIR452 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR452 Gene

Chromosome:
X
Start:
151,953,124 bp from pter
End:
151,974,680 bp from pter
Size:
21,557 bases
Orientation:
Minus strand

Genomic View for MIR452 Gene

Genes around MIR452 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR452 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR452 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR452 Gene

Proteins for MIR452 Gene

  • Protein details for MIR452 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78334-GBRE_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor subunit epsilon
    Protein Accession:
    P78334
    Secondary Accessions:
    • E7ET93
    • O15345
    • O15346
    • Q6PCD2
    • Q99520

    Protein attributes for MIR452 Gene

    Size:
    506 amino acids
    Molecular mass:
    57972 Da
    Quaternary structure:
    • Generally pentameric. Associates with alpha and beta subunits.
    • Generally pentameric. Associates with alpha and beta subunits.
    • Generally pentameric. Associates with alpha and beta subunits.

    Alternative splice isoforms for MIR452 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR452 Gene

Post-translational modifications for MIR452 Gene

  • Glycosylation at Asn 134 and Asn 252
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR452 Gene

No data available for DME Specific Peptides for MIR452 Gene

Domains & Families for MIR452 Gene

Gene Families for MIR452 Gene

Graphical View of Domain Structure for InterPro Entry

P78334

UniProtKB/Swiss-Prot:

GBRE_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily.
genes like me logo Genes that share domains with MIR452: view

No data available for Suggested Antigen Peptide Sequences for MIR452 Gene

Function for MIR452 Gene

Molecular function for MIR452 Gene

UniProtKB/Swiss-Prot Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Gene Ontology (GO) - Molecular Function for MIR452 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005254 chloride channel activity IEA --
genes like me logo Genes that share ontologies with MIR452: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR452 Gene

Localization for MIR452 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR452 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR452 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS --
GO:0030054 cell junction IEA --
GO:0034707 chloride channel complex IEA --
GO:0045211 postsynaptic membrane IEA --
GO:1902711 GABA-A receptor complex IBA --
genes like me logo Genes that share ontologies with MIR452: view

No data available for Subcellular locations from COMPARTMENTS for MIR452 Gene

Pathways & Interactions for MIR452 Gene

SuperPathways for MIR452 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR452 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS --
GO:0007214 gamma-aminobutyric acid signaling pathway TAS --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with MIR452: view

No data available for Pathways by source and SIGNOR curated interactions for MIR452 Gene

Drugs & Compounds for MIR452 Gene

No Compound Related Data Available

Transcripts for MIR452 Gene

mRNA/cDNA for MIR452 Gene

(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR452 Gene

No ASD Table

Relevant External Links for MIR452 Gene

GeneLoc Exon Structure for
MIR452
ECgene alternative splicing isoforms for
MIR452

Expression for MIR452 Gene

mRNA expression in normal human tissues for MIR452 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR452 Gene:

MIR452

mRNA Expression by UniProt/SwissProt for MIR452 Gene:

P78334-GBRE_HUMAN
Tissue specificity: Expressed in many tissues. Highest levels of expression in adult heart and placenta.
genes like me logo Genes that share expression patterns with MIR452: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR452 Gene

Orthologs for MIR452 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR452 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GABRE 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gabre 35
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 33 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia GABRE 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GABRE 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves GABRG4 35
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01113152.1 35
  • 20 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8916 35
  • 24 (a)
ManyToMany
Grd 35
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lgc-36 35
  • 22 (a)
ManyToMany
lgc-37 35
  • 29 (a)
ManyToMany
Species where no ortholog for MIR452 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR452 Gene

ENSEMBL:
Gene Tree for MIR452 (if available)
TreeFam:
Gene Tree for MIR452 (if available)

Paralogs for MIR452 Gene

Paralogs for MIR452 Gene

genes like me logo Genes that share paralogs with MIR452: view

Variants for MIR452 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR452 Gene

Variant ID Type Subtype PubMed ID
nsv510867 CNV deletion 20534489

Relevant External Links for MIR452 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR452

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR452 Gene

Disorders for MIR452 Gene

Relevant External Links for MIR452

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR452

No disorders were found for MIR452 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR452 Gene

Publications for MIR452 Gene

  1. Up-Regulation of MiR-452 Inhibits Metastasis of Non-Small Cell Lung Cancer by Regulating BMI1. (PMID: 26316085) He Z. … Chen Y. (Cell. Physiol. Biochem. 2015) 3 65
  2. MicroRNA-452 promotes tumorigenesis in hepatocellular carcinoma by targeting cyclin-dependent kinase inhibitor 1B. (PMID: 24381057) Zheng Q. … Zhang Y. (Mol. Cell. Biochem. 2014) 3 65
  3. Regulatory feedback loop between T3 and microRNAs in renal cancer. (PMID: 24440748) Boguslawska J. … Nauman A. (Mol. Cell. Endocrinol. 2014) 3 65
  4. MicroRNA-452 contributes to the docetaxel resistance of breast cancer cells. (PMID: 24648265) Hu Q. … Zhao J.H. (Tumour Biol. 2014) 3 65
  5. Hypermethylation of the GABRE~miR-452~miR-224 promoter in prostate cancer predicts biochemical recurrence after radical prostatectomy. (PMID: 24737792) Kristensen H. … rensen K.D. (Clin. Cancer Res. 2014) 3 65

Products for MIR452 Gene

Sources for MIR452 Gene

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