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Aliases for MIR452 Gene

Subcategory (RNA class) for MIR452 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR452 Gene

  • MicroRNA 452 2 3
  • Hsa-Mir-452 3
  • Mir-452 3
  • MIRN452 3

External Ids for MIR452 Gene

Previous HGNC Symbols for MIR452 Gene

  • MIRN452

Previous GeneCards Identifiers for MIR452 Gene

  • GC0XM150878
  • GC0XM151128

Summaries for MIR452 Gene

Entrez Gene Summary for MIR452 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR452 Gene

MIR452 (MicroRNA 452) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR452 Gene

Genomics for MIR452 Gene

Genomic Location for MIR452 Gene

Chromosome:
X
Start:
151,959,607 bp from pter
End:
151,959,719 bp from pter
Size:
113 bases
Orientation:
Minus strand

Genomic View for MIR452 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR452 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR452 Gene

No data available for Regulatory Elements for MIR452 Gene

Proteins for MIR452 Gene

Post-translational modifications for MIR452 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR452 Gene

Domains & Families for MIR452 Gene

Gene Families for MIR452 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR452: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR452 Gene

Function for MIR452 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR452 Gene

Localization for MIR452 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR452 Gene

Pathways & Interactions for MIR452 Gene

SuperPathways for MIR452 Gene

No Data Available

Interacting Proteins for MIR452 Gene

Gene Ontology (GO) - Biological Process for MIR452 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR452 Gene

Drugs & Compounds for MIR452 Gene

No Compound Related Data Available

Transcripts for MIR452 Gene

mRNA/cDNA for MIR452 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR452 Gene

No ASD Table

Relevant External Links for MIR452 Gene

GeneLoc Exon Structure for
MIR452
ECgene alternative splicing isoforms for
MIR452

Expression for MIR452 Gene

mRNA expression in normal human tissues for MIR452 Gene

genes like me logo Genes that share expression patterns with MIR452: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR452 Gene

Orthologs for MIR452 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR452 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-452 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-452 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir452 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-452 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR452:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR452 Gene

ENSEMBL:
Gene Tree for MIR452 (if available)
TreeFam:
Gene Tree for MIR452 (if available)

Paralogs for MIR452 Gene

No data available for Paralogs for MIR452 Gene

Variants for MIR452 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR452 Gene

Variant ID Type Subtype PubMed ID
nsv510867 CNV Loss 20534489

Relevant External Links for MIR452 Gene

HapMap Linkage Disequilibrium report
MIR452

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR452 Gene

Disorders for MIR452 Gene

Relevant External Links for MIR452

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR452
genes like me logo Genes that share disorders with MIR452: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR452 Gene

Publications for MIR452 Gene

  1. I^-elemene reverses chemoresistance of breast cancer via regulating MDR-related microRNA expression. (PMID: 25562151) Zhang J. … Tang J.H. (Cell. Physiol. Biochem. 2014) 67
  2. Regulatory feedback loop between T3 and microRNAs in renal cancer. (PMID: 24440748) Boguslawska J. … Nauman A. (Mol. Cell. Endocrinol. 2014) 67
  3. Down-regulation of miRNA-452 is associated with adriamycin-resistance in breast cancer cells. (PMID: 25040964) Hu Q. … Tang J.H. (Asian Pac. J. Cancer Prev. 2014) 67
  4. MicroRNA-452 promotes tumorigenesis in hepatocellular carcinoma by targeting cyclin-dependent kinase inhibitor 1B. (PMID: 24381057) Zheng Q. … Zhang Y. (Mol. Cell. Biochem. 2014) 67
  5. Hypermethylation of the GABRE~miR-452~miR-224 promoter in prostate cancer predicts biochemical recurrence after radical prostatectomy. (PMID: 24737792) Kristensen H. … rensen K.D. (Clin. Cancer Res. 2014) 67

Products for MIR452 Gene

Sources for MIR452 Gene

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