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Aliases for MIR452 Gene

Subcategory (RNA class) for MIR452 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR452 Gene

  • MicroRNA 452 2 3 5
  • Hsa-Mir-452 3
  • Mir-452 3
  • MIRN452 3

External Ids for MIR452 Gene

Previous HGNC Symbols for MIR452 Gene

  • MIRN452

Previous GeneCards Identifiers for MIR452 Gene

  • GC0XM150878
  • GC0XM151128

Summaries for MIR452 Gene

Entrez Gene Summary for MIR452 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR452 Gene

MIR452 (MicroRNA 452) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR452 Gene

Genomics for MIR452 Gene

Regulatory Elements for MIR452 Gene

Enhancers for MIR452 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG151970 1.1 Ensembl ENCODE 0.4 -11.2 -11239 1.6 ELF3 NFIB ZSCAN4 ARID4B RAD21 RARA RFX5 RCOR1 CREM THAP11 GABRE MIR452 GC0XM151964
GH0XG151971 0.9 ENCODE 0.4 -14.1 -14112 4.2 TBP ZSCAN4 SIN3A RFX5 ZNF766 EGR1 SCRT2 CREM SP3 MCM3 GABRE ZNF185 MIR452 GC0XM151964
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR452 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR452 Gene

Chromosome:
X
Start:
151,959,628 bp from pter
End:
151,959,712 bp from pter
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR452 Gene

Genes around MIR452 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR452 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR452 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR452 Gene

Proteins for MIR452 Gene

Post-translational modifications for MIR452 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR452 Gene

Domains & Families for MIR452 Gene

Gene Families for MIR452 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR452: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR452 Gene

Function for MIR452 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR452 Gene

Localization for MIR452 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR452 Gene

Pathways & Interactions for MIR452 Gene

SuperPathways for MIR452 Gene

No Data Available

Interacting Proteins for MIR452 Gene

Gene Ontology (GO) - Biological Process for MIR452 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR452 Gene

Drugs & Compounds for MIR452 Gene

No Compound Related Data Available

Transcripts for MIR452 Gene

mRNA/cDNA for MIR452 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR452 Gene

No ASD Table

Relevant External Links for MIR452 Gene

GeneLoc Exon Structure for
MIR452
ECgene alternative splicing isoforms for
MIR452

Expression for MIR452 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR452 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR452 Gene:

MIR452
genes like me logo Genes that share expression patterns with MIR452: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR452 Gene

Orthologs for MIR452 Gene

Evolution for MIR452 Gene

ENSEMBL:
Gene Tree for MIR452 (if available)
TreeFam:
Gene Tree for MIR452 (if available)

No data available for Orthologs for MIR452 Gene

Paralogs for MIR452 Gene

No data available for Paralogs for MIR452 Gene

Variants for MIR452 Gene

Sequence variations from dbSNP and Humsavar for MIR452 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1001397434 -- 151,961,096(+) AGGCA(C/T)GTGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1010099404 -- 151,960,635(+) CCTAG(A/G)TGACC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1010458836 -- 151,961,040(+) CCAAG(A/G)TAGTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1012489166 -- 151,959,304(+) AATCT(G/T)TGCTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1014151533 -- 151,961,434(+) GTCTA(C/G)GGACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR452 Gene

Variant ID Type Subtype PubMed ID
nsv510867 CNV deletion 20534489

Relevant External Links for MIR452 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR452

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR452 Gene

Disorders for MIR452 Gene

Relevant External Links for MIR452

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR452

No disorders were found for MIR452 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR452 Gene

Publications for MIR452 Gene

  1. Expression of microRNA-452 via adenoviral vector inhibits non-small cell lung cancer cells proliferation and metastasis. (PMID: 26718215) Zhang Y. … Jiang Q. (Tumour Biol. 2016) 3 64
  2. Decreased microRNA-452 expression and its prognostic significance in human osteosarcoma. (PMID: 27193084) Li R.Z. … Wang L.M. (World J Surg Oncol 2016) 3 64
  3. Up-Regulation of MiR-452 Inhibits Metastasis of Non-Small Cell Lung Cancer by Regulating BMI1. (PMID: 26316085) He Z. … Chen Y. (Cell. Physiol. Biochem. 2015) 3 64
  4. E2F1 induces miR-224/452 expression to drive EMT through TXNIP downregulation. (PMID: 25341426) Knoll S. … PA1tzer B.M. (EMBO Rep. 2014) 3 64
  5. MicroRNA-452 promotes tumorigenesis in hepatocellular carcinoma by targeting cyclin-dependent kinase inhibitor 1B. (PMID: 24381057) Zheng Q. … Zhang Y. (Mol. Cell. Biochem. 2014) 3 64

Products for MIR452 Gene

Sources for MIR452 Gene

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