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Aliases for MIR451B Gene

Subcategory (RNA class) for MIR451B Gene


Quality Score for this RNA gene is


Aliases for MIR451B Gene

  • MicroRNA 451b 2 3 5
  • Hsa-Mir-451b 3

External Ids for MIR451B Gene

ORGUL Members for MIR451B Gene

Previous GeneCards Identifiers for MIR451B Gene

  • GC17U901655
  • GC17M027195
  • GC17P027190

Summaries for MIR451B Gene

Entrez Gene Summary for MIR451B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR451B Gene

MIR451B (MicroRNA 451b) is an RNA Gene, and is affiliated with the undefined RNA class.

Additional gene information for MIR451B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR451B Gene

Genomics for MIR451B Gene

Genomic Location for MIR451B Gene

28,861,371 bp from pter
28,861,438 bp from pter
68 bases
Plus strand

Genomic View for MIR451B Gene

Genes around MIR451B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR451B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR451B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR451B Gene

No data available for Regulatory Elements for MIR451B Gene

Proteins for MIR451B Gene

Post-translational modifications for MIR451B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR451B Gene

Domains & Families for MIR451B Gene

Gene Families for MIR451B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR451B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR451B Gene

Function for MIR451B Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR451B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR451B Gene

Localization for MIR451B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR451B Gene

Pathways & Interactions for MIR451B Gene

SuperPathways for MIR451B Gene

No Data Available

Interacting Proteins for MIR451B Gene

Gene Ontology (GO) - Biological Process for MIR451B Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR451B Gene

Drugs & Compounds for MIR451B Gene

No Compound Related Data Available

Transcripts for MIR451B Gene

mRNA/cDNA for MIR451B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR451B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR451B Gene

No ASD Table

Relevant External Links for MIR451B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR451B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR451B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR451B Gene:

genes like me logo Genes that share expression patterns with MIR451B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR451B Gene

Orthologs for MIR451B Gene

Evolution for MIR451B Gene

Gene Tree for MIR451B (if available)
Gene Tree for MIR451B (if available)

No data available for Orthologs for MIR451B Gene

Paralogs for MIR451B Gene

No data available for Paralogs for MIR451B Gene

Variants for MIR451B Gene

Sequence variations from dbSNP and Humsavar for MIR451B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000983181 -- 28,861,821(+) CTCAT(A/G)GGGAC downstream-variant-500B, upstream-variant-2KB
rs1002743515 -- 28,859,626(+) CCTCC(A/G)CCTCC intron-variant, upstream-variant-2KB
rs1005255053 -- 28,860,881(+) GAGTC(A/C/G)CTGTT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1008639595 -- 28,860,597(+) GCTGC(A/T)GGCAG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1009088463 -- 28,860,303(+) GGGGT(C/T)GCACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR451B Gene

Variant ID Type Subtype PubMed ID
esv3640315 CNV loss 21293372

Relevant External Links for MIR451B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR451B Gene

Disorders for MIR451B Gene

Relevant External Links for MIR451B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR451B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR451B Gene

Publications for MIR451B Gene

  1. microRNA-451 inhibited cell proliferation, migration and invasion through regulation of MIF in renal cell carcinoma. (PMID: 26884830) Tang Y … Zhang J (International journal of clinical and experimental pathology 2015) 3 60
  2. MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1. (PMID: 26019450) Zang WQ … Zhao GQ (World journal of gastroenterology 2015) 3 60
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 60
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR451B Gene

Sources for MIR451B Gene

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