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Aliases for MIR451B Gene

Subcategory (RNA class) for MIR451B Gene


Quality Score for this RNA gene is


Aliases for MIR451B Gene

  • MicroRNA 451b 5 2 3
  • Hsa-Mir-451b 3

External Ids for MIR451B Gene

Previous GeneCards Identifiers for MIR451B Gene

  • GC17U901655
  • GC17M027195
  • GC17P027190

Summaries for MIR451B Gene

Entrez Gene Summary for MIR451B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR451B Gene

MIR451B (MicroRNA 451b) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR451B Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR451B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR451B Gene

Genomics for MIR451B Gene

Regulatory Elements for MIR451B Gene

Promoters for MIR451B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR451B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR451B Gene

28,861,371 bp from pter
28,861,438 bp from pter
68 bases
Plus strand

Genomic View for MIR451B Gene

Genes around MIR451B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR451B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR451B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR451B Gene

ORGUL Member Location for MIR451B Gene

ORGUL Member Location for MIR451B gene

Proteins for MIR451B Gene

Post-translational modifications for MIR451B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR451B Gene

Domains & Families for MIR451B Gene

Gene Families for MIR451B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR451B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR451B Gene

Function for MIR451B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR451B Gene

Localization for MIR451B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR451B Gene

Pathways & Interactions for MIR451B Gene

SuperPathways for MIR451B Gene

No Data Available

Interacting Proteins for MIR451B Gene

Gene Ontology (GO) - Biological Process for MIR451B Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR451B Gene

Drugs & Compounds for MIR451B Gene

No Compound Related Data Available

Transcripts for MIR451B Gene

fRNAdb Secondary structures for MIR451B Gene

  • FR509918
  • hsa-mir-451a_MI0001729_Homo_sapiens_miR-451a_stem-loop_hairpin

mRNA/cDNA for MIR451B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR451B Gene

No ASD Table

Relevant External Links for MIR451B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR451B Gene

mRNA expression in normal human tissues for MIR451B Gene

genes like me logo Genes that share expression patterns with MIR451B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR451B Gene

Orthologs for MIR451B Gene

Evolution for MIR451B Gene

Gene Tree for MIR451B (if available)
Gene Tree for MIR451B (if available)

No data available for Orthologs for MIR451B Gene

Paralogs for MIR451B Gene

No data available for Paralogs for MIR451B Gene

Variants for MIR451B Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for MIR451B Gene

Disorders for MIR451B Gene

Relevant External Links for MIR451B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR451B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR451B Gene

Publications for MIR451B Gene

  1. MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1. (PMID: 26019450) Zang W.Q. … Zhao G.Q. (World J. Gastroenterol. 2015) 3 67
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3
  3. Identification and classification of conserved RNA secondary structures in the human genome. (PMID: 16628248) Pedersen J.S. … Haussler D. (PLoS Comput. Biol. 2006) 1
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  5. RNAdb--a comprehensive mammalian noncoding RNA database. (PMID: 15608161) Pang K.C. … Mattick J.S. (Nucleic Acids Res. 2005) 1

Products for MIR451B Gene

Sources for MIR451B Gene