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Aliases for MIR451A Gene

Subcategory (RNA class) for MIR451A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR451A Gene

  • MicroRNA 451a 2 3
  • MicroRNA 451 2 3
  • Hsa-Mir-451a 3
  • Hsa-Mir-451 3
  • Mir-451a 3
  • MIRN451 3
  • MIR451 3

External Ids for MIR451A Gene

Previous HGNC Symbols for MIR451A Gene

  • MIRN451
  • MIR451

Previous GeneCards Identifiers for MIR451A Gene

  • GC17M027190
  • GC17M027194
  • GC17M027268

Summaries for MIR451A Gene

Entrez Gene Summary for MIR451A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR451A Gene

MIR451A (MicroRNA 451a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR451A Gene

Genomics for MIR451A Gene

Genomic Location for MIR451A Gene

Chromosome:
17
Start:
28,861,369 bp from pter
End:
28,861,440 bp from pter
Size:
72 bases
Orientation:
Minus strand

Genomic View for MIR451A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR451A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR451A Gene

No data available for Regulatory Elements for MIR451A Gene

Proteins for MIR451A Gene

Post-translational modifications for MIR451A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR451A Gene

Domains & Families for MIR451A Gene

Gene Families for MIR451A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR451A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR451A Gene

Function for MIR451A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR451A Gene

Localization for MIR451A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR451A Gene

Pathways & Interactions for MIR451A Gene

SuperPathways for MIR451A Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR451A: view

Pathways by source for MIR451A Gene

1 KEGG pathway for MIR451A Gene

Interacting Proteins for MIR451A Gene

Gene Ontology (GO) - Biological Process for MIR451A Gene

None

No data available for SIGNOR curated interactions for MIR451A Gene

Drugs & Compounds for MIR451A Gene

No Compound Related Data Available

Transcripts for MIR451A Gene

mRNA/cDNA for MIR451A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR451A Gene

No ASD Table

Relevant External Links for MIR451A Gene

GeneLoc Exon Structure for
MIR451A
ECgene alternative splicing isoforms for
MIR451A

Expression for MIR451A Gene

No Expression Related Data Available

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR451A Gene

Orthologs for MIR451A Gene

Evolution for MIR451A Gene

ENSEMBL:
Gene Tree for MIR451A (if available)
TreeFam:
Gene Tree for MIR451A (if available)

No data available for Orthologs for MIR451A Gene

Paralogs for MIR451A Gene

No data available for Paralogs for MIR451A Gene

Variants for MIR451A Gene

Relevant External Links for MIR451A Gene

HapMap Linkage Disequilibrium report
MIR451A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR451A Gene

Disorders for MIR451A Gene

Relevant External Links for MIR451A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR451A
genes like me logo Genes that share disorders with MIR451A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR451A Gene

Publications for MIR451A Gene

  1. MIR144 and MIR451 regulate human erythropoiesis via RAB14. (PMID: 25312678) Kim M. … Civin C.I. (Br. J. Haematol. 2015) 67
  2. Suppression of liver receptor homolog-1 by microRNA-451 represses the proliferation of osteosarcoma cells. (PMID: 25869073) Li Z. … Guo Q. (Biochem. Biophys. Res. Commun. 2015) 67
  3. MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. (PMID: 25362209) Kuwabara Y. … Ono K. (Circ. Res. 2015) 67
  4. Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression. (PMID: 25151965) Zhang J. … Chen W. (Oncogene 2015) 67
  5. MiR-451 suppresses cell proliferation and metastasis in A549 lung cancer cells. (PMID: 25150396) Yin P. … Zhang Z. (Mol. Biotechnol. 2015) 67

Products for MIR451A Gene

Sources for MIR451A Gene

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