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Aliases for MIR451A Gene

Subcategory (RNA class) for MIR451A Gene

lncRNA

Quality Score for this RNA gene is

3.2

Aliases for MIR451A Gene

  • MicroRNA 451a 2 3
  • MicroRNA 451 2 3
  • MicroRNA 4732 5
  • Hsa-Mir-451a 3
  • Hsa-Mir-451 3
  • Mir-451a 3
  • MIR4732 5
  • MIRN451 3
  • MIR451 3

External Ids for MIR451A Gene

ORGUL Members for MIR451A Gene

Previous HGNC Symbols for MIR451A Gene

  • MIRN451
  • MIR451

Previous GeneCards Identifiers for MIR451A Gene

  • GC17M027190
  • GC17M027194
  • GC17M027268

Summaries for MIR451A Gene

Entrez Gene Summary for MIR451A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR451A Gene

MIR451A (MicroRNA 451a) is an RNA Gene, and is affiliated with the lncRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR451A Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR451A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR451A Gene

Genomics for MIR451A Gene

Regulatory Elements for MIR451A Gene

Enhancers for MIR451A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F028863 1.5 FANTOM5 Ensembl ENCODE 0.8 -3.4 -3371 3.3 HDGF ATF1 ARNT CREB3L1 ARID4B ZNF48 ELK1 GATA2 KLF13 JUNB DHRS13 PROCA1 MIR4723 FLOT2 NEK8 TLCD1 SNORD42A SNORD4B SNORD42B RAB34
GH17F028861 0.8 ENCODE 0.8 -0.4 -386 1.9 HDGF TBP HDAC1 CBX3 TBL1XR1 NFRKB ZBTB2 SMAD5 HCFC1 ZBTB11 ENSG00000264577 SDF2 MIR4723 NUFIP2 FLOT2 DHRS13 RPL23A PHF12 KIAA0100 PROCA1
GH17F028870 1.1 Ensembl ENCODE 0.4 -9.6 -9606 1.5 CTCF TBP PKNOX1 MAX RAD21 ZBTB40 RELA ZNF316 POLR2A ETV6 FLOT2 DHRS13 MYO18A MIR144 MIR451A MIR4732 ENSG00000264304
GH17F028872 0.6 FANTOM5 0.4 -11.0 -10952 0.2 HDAC1 PKNOX1 NFRKB GATA2 SCRT2 CREM ZBTB2 ZEB2 CREB3 MBD2 DHRS13 FLOT2 MIR144 MIR451A MIR4732 ENSG00000264304
GH17F028879 0.5 ENCODE 0.3 -17.2 -17232 0.2 CTCF ZNF654 PKNOX1 TEAD1 TEAD4 NFYC TEAD2 REST RAD21 TEAD3 ENSG00000264304 MIR144 MIR451A MIR4732
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR451A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR451A Gene

Chromosome:
17
Start:
28,861,072 bp from pter
End:
28,861,966 bp from pter
Size:
895 bases
Orientation:
Minus strand

Genomic View for MIR451A Gene

Genes around MIR451A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR451A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR451A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR451A Gene

ORGUL Member Location for MIR451A Gene

ORGUL Member Location for MIR451A gene

Proteins for MIR451A Gene

Post-translational modifications for MIR451A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR451A Gene

Domains & Families for MIR451A Gene

Gene Families for MIR451A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR451A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR451A Gene

Function for MIR451A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR451A Gene

Localization for MIR451A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR451A Gene

Pathways & Interactions for MIR451A Gene

SuperPathways for MIR451A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR451A: view

Pathways by source for MIR451A Gene

1 KEGG pathway for MIR451A Gene

Interacting Proteins for MIR451A Gene

Gene Ontology (GO) - Biological Process for MIR451A Gene

None

No data available for SIGNOR curated interactions for MIR451A Gene

Transcripts for MIR451A Gene

fRNAdb Secondary structures for MIR451A Gene

  • FR102080

mRNA/cDNA for MIR451A Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR451A Gene

No ASD Table

Relevant External Links for MIR451A Gene

GeneLoc Exon Structure for
MIR451A
ECgene alternative splicing isoforms for
MIR451A

Expression for MIR451A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR451A Gene:

MIR451A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR451A Gene

Orthologs for MIR451A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR451A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-144 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir144 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-144 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-144 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-144 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-144 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-144 35
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-144 35
  • 72 (a)
OneToOne
Species where no ortholog for MIR451A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR451A Gene

ENSEMBL:
Gene Tree for MIR451A (if available)
TreeFam:
Gene Tree for MIR451A (if available)

Paralogs for MIR451A Gene

No data available for Paralogs for MIR451A Gene

Variants for MIR451A Gene

Sequence variations from dbSNP and Humsavar for MIR451A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1042938 -- 28,860,992(+) CAATT(C/T)TTGAT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1109024 -- 28,862,953(+) TTTTT(C/T)CTTCC upstream-variant-2KB
rs112618036 -- 28,861,741(+) CCAGC(A/G)TCTCC downstream-variant-500B, upstream-variant-2KB
rs113231461 -- 28,861,986(+) CTGTC(-/CCTTCCTCTT)CCCTC upstream-variant-2KB
rs114228298 -- 28,861,975(+) TGCAG(A/G)GAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR451A Gene

Variant ID Type Subtype PubMed ID
esv3640315 CNV loss 21293372

Relevant External Links for MIR451A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR451A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR451A Gene

Disorders for MIR451A Gene

Relevant External Links for MIR451A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR451A

No disorders were found for MIR451A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR451A Gene

Publications for MIR451A Gene

  1. MicroRNA Profiling in Aqueous Humor of Individual Human Eyes by Next-Generation Sequencing. (PMID: 27064390) Wecker T. … Schlunck G. (Invest. Ophthalmol. Vis. Sci. 2016) 3 64
  2. MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO. (PMID: 26990877) Kohrs N. … Lausen J. (PLoS Genet. 2016) 3 64
  3. Mir-451 Correlates with Prognosis of Renal Cell Carcinoma Patients and Inhibits Cellular Proliferation of Renal Cell Carcinoma. (PMID: 26779781) Zhu S. … Su X. (Med. Sci. Monit. 2016) 3 64
  4. miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway. (PMID: 26458815) Riquelme I. … Roa J.C. (Cell Oncol (Dordr) 2016) 3 64
  5. MIR144 and MIR451 regulate human erythropoiesis via RAB14. (PMID: 25312678) Kim M. … Civin C.I. (Br. J. Haematol. 2015) 3 64

Products for MIR451A Gene

Sources for MIR451A Gene

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