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Aliases for MIR451A Gene

Subcategory (RNA class) for MIR451A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR451A Gene

  • MicroRNA 451a 2 3 5
  • MicroRNA 451 2 3
  • Hsa-Mir-451a 3
  • Hsa-Mir-451 3
  • Mir-451a 3
  • MIRN451 3
  • MIR451 3

External Ids for MIR451A Gene

Previous HGNC Symbols for MIR451A Gene

  • MIRN451
  • MIR451

Previous GeneCards Identifiers for MIR451A Gene

  • GC17M027190
  • GC17M027194
  • GC17M027268

Summaries for MIR451A Gene

Entrez Gene Summary for MIR451A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR451A Gene

MIR451A (MicroRNA 451a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR451A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR451A

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR451A Gene

Genomics for MIR451A Gene

Genomic Location for MIR451A Gene

Chromosome:
17
Start:
28,861,369 bp from pter
End:
28,861,440 bp from pter
Size:
72 bases
Orientation:
Minus strand

Genomic View for MIR451A Gene

Genes around MIR451A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR451A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR451A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR451A Gene

ORGUL Member Location for MIR451A Gene

ORGUL Member Location for MIR451A gene

No data available for Regulatory Elements for MIR451A Gene

Proteins for MIR451A Gene

Post-translational modifications for MIR451A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR451A Gene

Domains & Families for MIR451A Gene

Gene Families for MIR451A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR451A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR451A Gene

Function for MIR451A Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR451A Gene

Localization for MIR451A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR451A Gene

Pathways & Interactions for MIR451A Gene

SuperPathways for MIR451A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR451A: view

Pathways by source for MIR451A Gene

1 KEGG pathway for MIR451A Gene

Interacting Proteins for MIR451A Gene

Gene Ontology (GO) - Biological Process for MIR451A Gene

None

No data available for SIGNOR curated interactions for MIR451A Gene

Drugs & Compounds for MIR451A Gene

No Compound Related Data Available

Transcripts for MIR451A Gene

fRNAdb Secondary structures for MIR451A Gene

  • FR509918
  • hsa-mir-451a_MI0001729_Homo_sapiens_miR-451a_stem-loop_hairpin

mRNA/cDNA for MIR451A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR451A Gene

No ASD Table

Relevant External Links for MIR451A Gene

GeneLoc Exon Structure for
MIR451A
ECgene alternative splicing isoforms for
MIR451A

Expression for MIR451A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR451A Gene:

MIR451A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR451A Gene

Orthologs for MIR451A Gene

Evolution for MIR451A Gene

ENSEMBL:
Gene Tree for MIR451A (if available)
TreeFam:
Gene Tree for MIR451A (if available)

No data available for Orthologs for MIR451A Gene

Paralogs for MIR451A Gene

No data available for Paralogs for MIR451A Gene

Variants for MIR451A Gene

Sequence variations from dbSNP and Humsavar for MIR451A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000736932 -- 28,862,534(+) CTACT(A/G)GGAGA upstream-variant-2KB
rs1000983181 -- 28,861,821(+) CTCAT(A/G)GGGAC downstream-variant-500B, upstream-variant-2KB
rs1001880847 -- 28,863,066(+) CCTCC(C/T)AAGTA upstream-variant-2KB
rs1002142648 -- 28,863,379(+) TAATA(C/T)ATTTC upstream-variant-2KB
rs1002398588 -- 28,862,610(+) AGAGC(C/G)TAGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR451A Gene

Variant ID Type Subtype PubMed ID
esv3640315 CNV loss 21293372

Relevant External Links for MIR451A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR451A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR451A Gene

Disorders for MIR451A Gene

Relevant External Links for MIR451A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR451A

No disorders were found for MIR451A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR451A Gene

Publications for MIR451A Gene

  1. Clustering and conservation patterns of human microRNAs. (PMID: 15891114) Altuvia Y. … Margalit H. (Nucleic Acids Res. 2005) 1 3 64
  2. Identification of clustered microRNAs using an ab initio prediction method. (PMID: 16274478) Sewer A. … Zavolan M. (BMC Bioinformatics 2005) 1 3 64
  3. Downregulation of miR-451 in Tunisian chronic myeloid leukemia patients: potential implication in imatinib resistance. (PMID: 27825294) Soltani I. … Menif S. (Hematology 2017) 3 64
  4. A novel signaling role for miR-451 in esophageal tumor microenvironment and its contribution to tumor progression. (PMID: 27896643) Khazaei S. … Mowla S.J. (Clin Transl Oncol 2017) 3 64
  5. MiR-451 suppresses proliferation, migration and promotes apoptosis of the human osteosarcoma by targeting macrophage migration inhibitory factor. (PMID: 28086136) Liu W. … Yu B. (Biomed. Pharmacother. 2017) 3 64

Products for MIR451A Gene

Sources for MIR451A Gene

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