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Aliases for MIR4517 Gene

Subcategory (RNA class) for MIR4517 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4517 Gene

  • MicroRNA 4517 2 3
  • NFATC2IP 4 5
  • Nuclear Factor Of Activated T-Cells, Cytoplasmic 2-Interacting Protein 4
  • Nuclear Factor Of Activated T-Cells 2 Interacting Protein 5
  • 45 KDa NF-AT-Interacting Protein 4
  • 45 KDa NFAT-Interacting Protein 4
  • Hsa-Mir-4517 3
  • Mir-4517 3
  • NIP45 4

External Ids for MIR4517 Gene

Previous GeneCards Identifiers for MIR4517 Gene

  • GC16U901341
  • GC16P028971

Summaries for MIR4517 Gene

Entrez Gene Summary for MIR4517 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4517 Gene

MIR4517 (MicroRNA 4517) is an RNA Gene, and is affiliated with the miRNA class.

UniProtKB/Swiss-Prot for MIR4517 Gene

  • In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 Arg-3-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4517 Gene

Genomics for MIR4517 Gene

Regulatory Elements for MIR4517 Gene

Enhancers for MIR4517 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR4517 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4517 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR4517 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4517 Gene

Chromosome:
16
Start:
28,950,807 bp from pter
End:
28,967,097 bp from pter
Size:
16,291 bases
Orientation:
Plus strand

Genomic View for MIR4517 Gene

Genes around MIR4517 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4517 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4517 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4517 Gene

Proteins for MIR4517 Gene

  • Protein details for MIR4517 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCF5-NF2IP_HUMAN
    Recommended name:
    NFATC2-interacting protein
    Protein Accession:
    Q8NCF5
    Secondary Accessions:
    • B7Z4G5
    • Q66K34
    • Q6NVK1
    • Q8NFR2
    • Q96ST9

    Protein attributes for MIR4517 Gene

    Size:
    419 amino acids
    Molecular mass:
    45817 Da
    Quaternary structure:
    • Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9 (By similarity).
    • Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9 (By similarity).
    SequenceCaution:
    • Sequence=AAM49721.1; Type=Frameshift; Positions=107, 114; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR4517 Gene

    Alternative splice isoforms for MIR4517 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4517 Gene

Post-translational modifications for MIR4517 Gene

  • Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR4517 Gene

No data available for DME Specific Peptides for MIR4517 Gene

Domains & Families for MIR4517 Gene

Gene Families for MIR4517 Gene

Protein Domains for MIR4517 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCF5

UniProtKB/Swiss-Prot:

NF2IP_HUMAN :
  • Contains 1 ubiquitin-like domain.
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with MIR4517: view

No data available for Suggested Antigen Peptide Sequences for MIR4517 Gene

Function for MIR4517 Gene

Molecular function for MIR4517 Gene

UniProtKB/Swiss-Prot Function:
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 Arg-3-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Gene Ontology (GO) - Molecular Function for MIR4517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031386 protein tag IBA --
genes like me logo Genes that share ontologies with MIR4517: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4517 Gene

Localization for MIR4517 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4517 Gene

Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MIR4517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MIR4517: view

No data available for Subcellular locations from COMPARTMENTS for MIR4517 Gene

Pathways & Interactions for MIR4517 Gene

SuperPathways for MIR4517 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4517 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MIR4517: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4517 Gene

Drugs & Compounds for MIR4517 Gene

No Compound Related Data Available

Transcripts for MIR4517 Gene

mRNA/cDNA for MIR4517 Gene

(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4517 Gene

No ASD Table

Relevant External Links for MIR4517 Gene

GeneLoc Exon Structure for
MIR4517
ECgene alternative splicing isoforms for
MIR4517

Expression for MIR4517 Gene

mRNA expression in normal human tissues for MIR4517 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4517 Gene:

MIR4517
genes like me logo Genes that share expression patterns with MIR4517: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4517 Gene

Orthologs for MIR4517 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4517 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFATC2IP 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFATC2IP 35
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFATC2IP 35
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfatc2ip 35
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFATC2IP 35
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFATC2IP 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nfatc2ip 35
  • 31 (a)
OneToOne
Species where no ortholog for MIR4517 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4517 Gene

ENSEMBL:
Gene Tree for MIR4517 (if available)
TreeFam:
Gene Tree for MIR4517 (if available)

Paralogs for MIR4517 Gene

No data available for Paralogs for MIR4517 Gene

Variants for MIR4517 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4517 Gene

Variant ID Type Subtype PubMed ID
dgv2830n100 CNV gain 25217958
dgv2831n100 CNV gain 25217958
dgv4987n54 CNV gain 21841781
esv2758640 CNV gain+loss 17122850
esv3570454 CNV gain 25503493
esv3892826 CNV gain+loss 25118596
nsv1059555 CNV gain 25217958
nsv457480 CNV gain 19166990
nsv518648 CNV loss 19592680
nsv519100 CNV gain 19592680
nsv571805 CNV loss 21841781
nsv571808 CNV gain 21841781

Relevant External Links for MIR4517 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4517

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4517 Gene

Disorders for MIR4517 Gene

Relevant External Links for MIR4517

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4517

No disorders were found for MIR4517 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4517 Gene

Publications for MIR4517 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 65
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 65
  5. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 65

Products for MIR4517 Gene

Sources for MIR4517 Gene

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