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Aliases for MIR4516 Gene

Subcategory (RNA class) for MIR4516 Gene


Quality Score for this RNA gene is


Aliases for MIR4516 Gene

  • MicroRNA 4516 2 3 5
  • Hsa-Mir-4516 3
  • Mir-4516 3

External Ids for MIR4516 Gene

Previous GeneCards Identifiers for MIR4516 Gene

  • GC16U901349
  • GC16P002187
  • GC16P002142
  • GC16P002148
  • GC16P002150
  • GC16P002152
  • GC16P002154
  • GC16P002167
  • GC16P002191

Summaries for MIR4516 Gene

Entrez Gene Summary for MIR4516 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4516 Gene

MIR4516 (MicroRNA 4516) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4516 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4516 Gene

Genomics for MIR4516 Gene

GeneHancer (GH) Regulatory Elements for MIR4516 Gene

Promoters and enhancers for MIR4516 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I002133 Enhancer 0.3 dbSUPER 550.8 +0.6 636 0.3 REST ENSG00000200059 GC16P002180 GC16P002194 GC16P002200 GC16P002201 GC16P002202 GC16P002203 MIR4516 PIR59583 PKD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4516 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4516 Gene

Genomic Locations for MIR4516 Gene
86 bases
Plus strand

Genomic View for MIR4516 Gene

Genes around MIR4516 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4516 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4516 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4516 Gene

Proteins for MIR4516 Gene

Post-translational modifications for MIR4516 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4516 Gene

Domains & Families for MIR4516 Gene

Gene Families for MIR4516 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4516: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4516 Gene

Function for MIR4516 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4516 Gene

Localization for MIR4516 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4516 Gene

Pathways & Interactions for MIR4516 Gene

SuperPathways for MIR4516 Gene

No Data Available

Interacting Proteins for MIR4516 Gene

Gene Ontology (GO) - Biological Process for MIR4516 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4516 Gene

Drugs & Compounds for MIR4516 Gene

No Compound Related Data Available

Transcripts for MIR4516 Gene

mRNA/cDNA for MIR4516 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4516 Gene

No ASD Table

Relevant External Links for MIR4516 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4516 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4516 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4516 Gene:

genes like me logo Genes that share expression patterns with MIR4516: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4516 Gene

Orthologs for MIR4516 Gene

Evolution for MIR4516 Gene

Gene Tree for MIR4516 (if available)
Gene Tree for MIR4516 (if available)

No data available for Orthologs for MIR4516 Gene

Paralogs for MIR4516 Gene

No data available for Paralogs for MIR4516 Gene

Variants for MIR4516 Gene

Sequence variations from dbSNP and Humsavar for MIR4516 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1002707497 -- 2,132,325(+) T/C upstream_transcript_variant
rs1004768307 -- 2,133,462(+) A/C downstream_transcript_variant
rs1006841902 -- 2,132,009(+) G/C upstream_transcript_variant
rs1008399840 -- 2,132,873(+) G/A upstream_transcript_variant
rs1008515449 -- 2,133,163(+) GGGGGG/GGGGG/GGGGGGG non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4516 Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv26637 CNV loss 19812545
nsv1052260 CNV gain 25217958
nsv457349 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv471381 CNV gain 19718026
nsv482186 CNV gain 20164927
nsv571190 CNV loss 21841781
nsv571197 CNV gain 21841781
nsv827505 CNV gain 20364138
nsv827507 CNV gain 20364138
nsv9332 CNV loss 18304495
nsv952901 CNV deletion 24416366
nsv984250 CNV duplication 23825009

Additional Variant Information for MIR4516 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4516 Gene

Disorders for MIR4516 Gene

Additional Disease Information for MIR4516

No disorders were found for MIR4516 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4516 Gene

Publications for MIR4516 Gene

  1. hsa-miR-4516 mediated downregulation of STAT3/CDK6/UBE2N plays a role in PUVA induced apoptosis in keratinocytes. (PMID: 24610393) Chowdhari S … Saini N (Journal of cellular physiology 2014) 3 58
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4516 Gene

Sources for MIR4516 Gene

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