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Aliases for MIR4516 Gene

Subcategory (RNA class) for MIR4516 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4516 Gene

  • MicroRNA 4516 2 3 5
  • Hsa-Mir-4516 3
  • Mir-4516 3

External Ids for MIR4516 Gene

Previous GeneCards Identifiers for MIR4516 Gene

  • GC16U901349
  • GC16P002187
  • GC16P002142
  • GC16P002148

Summaries for MIR4516 Gene

Entrez Gene Summary for MIR4516 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4516 Gene

MIR4516 (MicroRNA 4516) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4516 Gene

Genomics for MIR4516 Gene

Genomic Location for MIR4516 Gene

Chromosome:
16
Start:
2,133,119 bp from pter
End:
2,133,204 bp from pter
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR4516 Gene

Genes around MIR4516 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4516 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4516 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4516 Gene

No data available for Regulatory Elements for MIR4516 Gene

Proteins for MIR4516 Gene

Post-translational modifications for MIR4516 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4516 Gene

Domains & Families for MIR4516 Gene

Gene Families for MIR4516 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4516: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4516 Gene

Function for MIR4516 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4516 Gene

Localization for MIR4516 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4516 Gene

Pathways & Interactions for MIR4516 Gene

SuperPathways for MIR4516 Gene

No Data Available

Interacting Proteins for MIR4516 Gene

Gene Ontology (GO) - Biological Process for MIR4516 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4516 Gene

Drugs & Compounds for MIR4516 Gene

No Compound Related Data Available

Transcripts for MIR4516 Gene

mRNA/cDNA for MIR4516 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4516 Gene

No ASD Table

Relevant External Links for MIR4516 Gene

GeneLoc Exon Structure for
MIR4516
ECgene alternative splicing isoforms for
MIR4516

Expression for MIR4516 Gene

mRNA expression in normal human tissues for MIR4516 Gene

genes like me logo Genes that share expression patterns with MIR4516: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR4516 Gene

Orthologs for MIR4516 Gene

Evolution for MIR4516 Gene

ENSEMBL:
Gene Tree for MIR4516 (if available)
TreeFam:
Gene Tree for MIR4516 (if available)

No data available for Orthologs for MIR4516 Gene

Paralogs for MIR4516 Gene

No data available for Paralogs for MIR4516 Gene

Variants for MIR4516 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4516 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv471072 CNV Loss 18288195
nsv905102 CNV Loss 21882294
dgv2556n71 CNV Loss 21882294
dgv2557n71 CNV Loss 21882294
nsv457349 CNV Loss 19166990
dgv2558n71 CNV Loss 21882294
nsv471381 CNV Duplication 19718026
nsv482186 CNV Gain 20164927
nsv827505 CNV Gain 20364138
nsv827507 CNV Gain 20364138
nsv9332 CNV Loss 18304495
dgv2562n71 CNV Loss 21882294
dgv2563n71 CNV Loss 21882294
esv26637 CNV Loss 19812545

Relevant External Links for MIR4516 Gene

HapMap Linkage Disequilibrium report
MIR4516

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4516 Gene

Disorders for MIR4516 Gene

Relevant External Links for MIR4516

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4516

No disorders were found for MIR4516 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4516 Gene

Publications for MIR4516 Gene

  1. hsa-miR-4516 mediated downregulation of STAT3/CDK6/UBE2N plays a role in PUVA induced apoptosis in keratinocytes. (PMID: 24610393) Chowdhari S. … Saini N. (J. Cell. Physiol. 2014) 3 67
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR4516 Gene

Sources for MIR4516 Gene

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