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Aliases for MIR4516 Gene

Subcategory (RNA class) for MIR4516 Gene


Quality Score for this RNA gene is


Aliases for MIR4516 Gene

  • MicroRNA 4516 2 3 5
  • Hsa-Mir-4516 3
  • Mir-4516 3

External Ids for MIR4516 Gene

Previous GeneCards Identifiers for MIR4516 Gene

  • GC16U901349
  • GC16P002187
  • GC16P002142
  • GC16P002148
  • GC16P002150
  • GC16P002152

Summaries for MIR4516 Gene

Entrez Gene Summary for MIR4516 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4516 Gene

MIR4516 (MicroRNA 4516) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4516 Gene

Genomics for MIR4516 Gene

Regulatory Elements for MIR4516 Gene

Promoters for MIR4516 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001798995 1081 401 REST ZNF600

Genomic Location for MIR4516 Gene

2,133,119 bp from pter
2,133,204 bp from pter
86 bases
Plus strand

Genomic View for MIR4516 Gene

Genes around MIR4516 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4516 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4516 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4516 Gene

Proteins for MIR4516 Gene

Post-translational modifications for MIR4516 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4516 Gene

Domains & Families for MIR4516 Gene

Gene Families for MIR4516 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4516: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4516 Gene

Function for MIR4516 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4516 Gene

Localization for MIR4516 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4516 Gene

Pathways & Interactions for MIR4516 Gene

SuperPathways for MIR4516 Gene

No Data Available

Interacting Proteins for MIR4516 Gene

Gene Ontology (GO) - Biological Process for MIR4516 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4516 Gene

Transcripts for MIR4516 Gene

mRNA/cDNA for MIR4516 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4516 Gene

No ASD Table

Relevant External Links for MIR4516 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4516 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4516 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4516 Gene:

genes like me logo Genes that share expression patterns with MIR4516: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4516 Gene

Orthologs for MIR4516 Gene

Evolution for MIR4516 Gene

Gene Tree for MIR4516 (if available)
Gene Tree for MIR4516 (if available)

No data available for Orthologs for MIR4516 Gene

Paralogs for MIR4516 Gene

No data available for Paralogs for MIR4516 Gene

Variants for MIR4516 Gene

Sequence variations from dbSNP and Humsavar for MIR4516 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs115749935 -- 2,133,129(+) GAAGG(A/G)TCGGG intron-variant, nc-transcript-variant
rs1793974 -- 2,131,263(-) aagtg(C/T)tggga intron-variant, upstream-variant-2KB
rs184386817 -- 2,131,998(+) GTAAT(C/T)CCAAC intron-variant, upstream-variant-2KB
rs189272979 -- 2,132,203(+) TGAGA(C/T)CGCGC intron-variant, upstream-variant-2KB
rs191871659 -- 2,133,624(+) AGGGC(C/T)TTCAC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4516 Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv26637 CNV loss 19812545
nsv1052260 CNV gain 25217958
nsv457349 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv471381 CNV gain 19718026
nsv482186 CNV gain 20164927
nsv571190 CNV loss 21841781
nsv571197 CNV gain 21841781
nsv827505 CNV gain 20364138
nsv827507 CNV gain 20364138
nsv9332 CNV loss 18304495
nsv952901 CNV deletion 24416366
nsv984250 CNV duplication 23825009

Relevant External Links for MIR4516 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4516 Gene

Disorders for MIR4516 Gene

Relevant External Links for MIR4516

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4516 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4516 Gene

Publications for MIR4516 Gene

  1. hsa-miR-4516 mediated downregulation of STAT3/CDK6/UBE2N plays a role in PUVA induced apoptosis in keratinocytes. (PMID: 24610393) Chowdhari S. … Saini N. (J. Cell. Physiol. 2014) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4516 Gene

Sources for MIR4516 Gene

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