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Aliases for MIR450B Gene

Subcategory (RNA class) for MIR450B Gene


Quality Score for this RNA gene is


Aliases for MIR450B Gene

  • MicroRNA 450b 2 3
  • Hsa-Mir-450b 3
  • MIRN450B 3

External Ids for MIR450B Gene

Previous HGNC Symbols for MIR450B Gene

  • MIRN450B

Previous GeneCards Identifiers for MIR450B Gene

  • GC0XM133516
  • GC0XM133524
  • GC0XM133674

Summaries for MIR450B Gene

Entrez Gene Summary for MIR450B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR450B Gene

MIR450B (MicroRNA 450b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR450B Gene

Genomics for MIR450B Gene

Genomic Location for MIR450B Gene

134,540,161 bp from pter
134,540,272 bp from pter
112 bases
Minus strand

Genomic View for MIR450B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR450B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR450B Gene

No data available for Regulatory Elements for MIR450B Gene

Proteins for MIR450B Gene

Post-translational modifications for MIR450B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR450B Gene

Domains for MIR450B Gene

Gene Families for MIR450B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR450B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR450B Gene

Function for MIR450B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR450B Gene

Localization for MIR450B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR450B Gene

Pathways for MIR450B Gene

SuperPathways for MIR450B Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR450B: view

Pathways by source for MIR450B Gene

1 BioSystems pathway for MIR450B Gene

Interacting Proteins for MIR450B Gene

Gene Ontology (GO) - Biological Process for MIR450B Gene


Transcripts for MIR450B Gene

mRNA/cDNA for MIR450B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR450B Gene

No ASD Table

Relevant External Links for MIR450B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR450B Gene

mRNA expression in normal human tissues for MIR450B Gene

genes like me logo Genes that share expressions with MIR450B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR450B Gene

Orthologs for MIR450B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR450B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-450b 36
  • 87 (a)
(Canis familiaris)
Mammalia cfa-mir-450b 36
  • 95 (a)
(Mus musculus)
Mammalia Mir450b 36
  • 84 (a)
(Pan troglodytes)
Mammalia ptr-mir-450b 36
  • 100 (a)
Species with no ortholog for MIR450B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR450B Gene

Gene Tree for MIR450B (if available)
Gene Tree for MIR450B (if available)

Paralogs for MIR450B Gene

No data available for Paralogs for MIR450B Gene

Variants for MIR450B Gene

Sequence variations from dbSNP and Humsavar for MIR450B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs184151457 -- 134,539,737(+) ACTTC(C/T)TTAAA downstream-variant-500B
rs189581822 -- 134,539,837(+) CTTTT(C/T)TTTGC downstream-variant-500B

Relevant External Links for MIR450B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIR450B Gene

Disorders for MIR450B Gene

No disorders were found for MIR450B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR450B Gene

Publications for MIR450B Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  3. TGF-I^1 suppression of microRNA-450b-5p expression: a novel mechanism for blocking myogenic differentiation of rhabdomyosarcoma. (PMID: 23665678) Sun M.M. … Wang S.L. (Oncogene 2013) 3
  4. Targeting HER3 with miR-450b-3p suppresses breast cancer cells proliferation. (PMID: 25046105) Zhao Z. … Liu T. (Cancer Biol. Ther. 2014) 3

Products for MIR450B Gene

Sources for MIR450B Gene

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