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Aliases for MIR450B Gene

Subcategory (RNA class) for MIR450B Gene


Quality Score for this RNA gene is


Aliases for MIR450B Gene

  • MicroRNA 450b 2 3 5
  • Hsa-Mir-450b 3
  • Mir-450b 3
  • MIRN450B 3

External Ids for MIR450B Gene

Previous HGNC Symbols for MIR450B Gene

  • MIRN450B

Previous GeneCards Identifiers for MIR450B Gene

  • GC0XM133516
  • GC0XM133524
  • GC0XM133674

Summaries for MIR450B Gene

Entrez Gene Summary for MIR450B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR450B Gene

MIR450B (MicroRNA 450b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR450B Gene

Genomics for MIR450B Gene

Regulatory Elements for MIR450B Gene

Enhancers for MIR450B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG134675 1.2 Ensembl ENCODE dbSUPER 12.5 -136.4 -136429 1.9 BCOR ZNF263 JUN ZNF837 SIN3A ZMYM3 NR3C1 EP300 ZKSCAN1 MAFF LINC00629 MIR503 MIR503HG MIR450A1 MIR450A2 MIR450B MIR542 GC0XP134651 GC0XM134761 RNU4-44P
GH0XG134751 0.7 ENCODE 13 -212.7 -212672 2.5 CTCF ZNF654 REST RAD21 GATA3 SCRT2 HMBOX1 SMC3 PRDM10 NFE2 LINC00629 MIR503 MIR503HG MIR450A1 MIR450A2 MIR450B MIR542 GC0XM134761 RNU4-44P GC0XP134651
GH0XG134570 0.7 ENCODE 12.9 -31.6 -31602 3.5 PKNOX1 ZNF146 ZIC2 GATA3 ZNF600 TCF7L2 ZNF263 CHD1 NR3C1 ATF2 MIR503HG LINC00629 MIR503 MIR450A1 MIR450A2 MIR450B MIR542 ENSG00000235813
GH0XG134678 0.5 ENCODE 12.5 -139.1 -139138 1.3 SREBF1 GLIS1 SPI1 LINC00629 MIR503 MIR503HG MIR450A1 MIR450A2 MIR450B MIR542 GC0XP134651 GC0XM134761 RNU4-44P
GH0XG134681 0.2 dbSUPER 12.5 -142.1 -142136 1.3 LINC00629 MIR503 MIR503HG MIR450A1 MIR450A2 MIR450B MIR542 GC0XP134651 GC0XM134761 RNU4-44P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR450B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR450B Gene

134,540,185 bp from pter
134,540,262 bp from pter
78 bases
Minus strand

Genomic View for MIR450B Gene

Genes around MIR450B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR450B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR450B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR450B Gene

Proteins for MIR450B Gene

Post-translational modifications for MIR450B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR450B Gene

Domains & Families for MIR450B Gene

Gene Families for MIR450B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR450B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR450B Gene

Function for MIR450B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR450B Gene

Localization for MIR450B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR450B Gene

Pathways & Interactions for MIR450B Gene

genes like me logo Genes that share pathways with MIR450B: view

Pathways by source for MIR450B Gene

1 BioSystems pathway for MIR450B Gene

Interacting Proteins for MIR450B Gene

Gene Ontology (GO) - Biological Process for MIR450B Gene


No data available for SIGNOR curated interactions for MIR450B Gene

Drugs & Compounds for MIR450B Gene

No Compound Related Data Available

Transcripts for MIR450B Gene

mRNA/cDNA for MIR450B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR450B Gene

No ASD Table

Relevant External Links for MIR450B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR450B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR450B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR450B Gene:

genes like me logo Genes that share expression patterns with MIR450B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR450B Gene

Orthologs for MIR450B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR450B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-450b 35
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-450b 35
  • 95 (a)
(Bos Taurus)
Mammalia bta-mir-450b 35
  • 87 (a)
(Mus musculus)
Mammalia Mir450b 35
  • 84 (a)
Species where no ortholog for MIR450B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR450B Gene

Gene Tree for MIR450B (if available)
Gene Tree for MIR450B (if available)

Paralogs for MIR450B Gene

No data available for Paralogs for MIR450B Gene

Variants for MIR450B Gene

Sequence variations from dbSNP and Humsavar for MIR450B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000102752 -- 134,541,665(+) TGCAG(A/G)TTTCC upstream-variant-2KB
rs1004364929 -- 134,541,852(+) GCTTG(A/C)CACTT upstream-variant-2KB
rs1004826828 -- 134,540,788(+) GAGCA(C/T)ATTCT upstream-variant-2KB
rs1005199261 -- 134,540,000(+) ATACA(A/G)ACTCT downstream-variant-500B
rs1010962031 -- 134,540,056(+) TTATT(C/G)TTTAT downstream-variant-500B

Relevant External Links for MIR450B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR450B Gene

Disorders for MIR450B Gene

Relevant External Links for MIR450B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR450B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR450B Gene

Publications for MIR450B Gene

  1. miR-450b-5p Suppresses Stemness and the Development of Chemoresistance by Targeting SOX2 in Colorectal Cancer. (PMID: 26845645) Jin Y. … Wang X. (DNA Cell Biol. 2016) 3 64
  2. Targeting HER3 with miR-450b-3p suppresses breast cancer cells proliferation. (PMID: 25046105) Zhao Z. … Liu T. (Cancer Biol. Ther. 2014) 3 64
  3. TGF-I^1 suppression of microRNA-450b-5p expression: a novel mechanism for blocking myogenic differentiation of rhabdomyosarcoma. (PMID: 23665678) Sun M.M. … Wang S.L. (Oncogene 2013) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64

Products for MIR450B Gene

Sources for MIR450B Gene

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