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Aliases for MIR449C Gene

Subcategory (RNA class) for MIR449C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR449C Gene

  • MicroRNA 449c 2 3
  • Hsa-Mir-449c 3

External Ids for MIR449C Gene

Previous GeneCards Identifiers for MIR449C Gene

  • GC00U929193
  • GC05U901223
  • GC05M054468
  • GC05M051441

Summaries for MIR449C Gene

Entrez Gene Summary for MIR449C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449C Gene

MIR449C (MicroRNA 449c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR449C Gene

Genomics for MIR449C Gene

Genomic Location for MIR449C Gene

Start:
55,172,262 bp from pter
End:
55,172,353 bp from pter
Size:
92 bases
Orientation:
Minus strand

Genomic View for MIR449C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR449C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449C Gene

No data available for Regulatory Elements for MIR449C Gene

Proteins for MIR449C Gene

Post-translational modifications for MIR449C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449C Gene

Domains for MIR449C Gene

Gene Families for MIR449C Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR449C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR449C Gene

Function for MIR449C Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR449C Gene

Localization for MIR449C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR449C Gene

Pathways for MIR449C Gene

SuperPathways for MIR449C Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR449C: view

Pathways by source for MIR449C Gene

1 BioSystems pathway for MIR449C Gene

Interacting Proteins for MIR449C Gene

Gene Ontology (GO) - Biological Process for MIR449C Gene

None

Transcripts for MIR449C Gene

mRNA/cDNA for MIR449C Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449C Gene

No ASD Table

Relevant External Links for MIR449C Gene

GeneLoc Exon Structure for
MIR449C
ECgene alternative splicing isoforms for
MIR449C

Expression for MIR449C Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR449C Gene

Orthologs for MIR449C Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR449C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-449c 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-449c 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir449c 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-449c 36
  • 52 (a)
OneToOne
Species with no ortholog for MIR449C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR449C Gene

ENSEMBL:
Gene Tree for MIR449C (if available)
TreeFam:
Gene Tree for MIR449C (if available)

Paralogs for MIR449C Gene

No data available for Paralogs for MIR449C Gene

Variants for MIR449C Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR449C Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV Gain 17160897

Relevant External Links for MIR449C Gene

HapMap Linkage Disequilibrium report
MIR449C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR449C Gene

Disorders for MIR449C Gene

No disorders were found for MIR449C Gene.

No data available for UniProtKB/Swiss-Prot for MIR449C Gene

Publications for MIR449C Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E. … Cuppen E. (Genome Res. 2006) 3
  3. Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries. (PMID: 19390579) Wyman S.K. … Tewari M. (PLoS ONE 2009) 3
  4. MiR-449c targets c-Myc and inhibits NSCLC cell progression. (PMID: 23507140) Miao L.J. … Wang J. (FEBS Lett. 2013) 3

Products for MIR449C Gene

Sources for MIR449C Gene

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