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Aliases for MIR449C Gene

Subcategory (RNA class) for MIR449C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR449C Gene

  • MicroRNA 449c 2 3 5
  • Hsa-Mir-449c 3
  • Mir-449c 3

External Ids for MIR449C Gene

Previous GeneCards Identifiers for MIR449C Gene

  • GC00U929193
  • GC05U901223
  • GC05M054468
  • GC05M051441

Summaries for MIR449C Gene

Entrez Gene Summary for MIR449C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449C Gene

MIR449C (MicroRNA 449c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response.

Additional gene information for MIR449C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR449C Gene

Genomics for MIR449C Gene

GeneHancer (GH) Regulatory Elements for MIR449C Gene

Promoters and enhancers for MIR449C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I055172 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 -1.1 -1139 1 HDAC1 PKNOX1 ATF1 RB1 SIN3A BMI1 ZNF2 ZNF335 GLIS2 ZNF391 CDC20B GC05M055174 MIR449C ENSG00000240535 LOC105378973 CCNO GC05P055180 PIR47804
GH05I055173 Enhancer 0.8 ENCODE 550.8 +0.1 85 0.2 RB1 ZSCAN4 ARID4B SIN3A BMI1 ZNF2 RAD21 RFX5 ZEB1 ZNF335 CDC20B GC05M055174 MIR449A MIR449B MIR449C
GH05I054900 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +270.2 270174 2.7 PKNOX1 MAX EBF1 BATF IRF4 RELA NFATC1 ETV6 FOS BCLAF1 GPX8 LOC100130990 ENSG00000249016 GZMK MIR449A MIR449B CDC20B MIR449C ENSG00000240535 SNX18
GH05I054906 Enhancer 0.6 ENCODE 10.6 +266.2 266215 0.1 CTCF ZNF654 TEAD1 TEAD4 INSM2 MAFG REST RAD21 YY1 TEAD3 GPX8 ENSG00000249016 GZMK MIR449A MIR449B CDC20B MIR449C ENSG00000240535 LOC100130990 SNX18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR449C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR449C Gene

Genomic Locations for MIR449C Gene
chr5:55,172,262-55,172,353
(GRCh38/hg38)
Size:
92 bases
Orientation:
Minus strand
chr5:54,468,090-54,468,181
(GRCh37/hg19)

Genomic View for MIR449C Gene

Genes around MIR449C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR449C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR449C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449C Gene

Proteins for MIR449C Gene

Post-translational modifications for MIR449C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449C Gene

Domains & Families for MIR449C Gene

Gene Families for MIR449C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR449C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR449C Gene

Function for MIR449C Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR449C Gene

Localization for MIR449C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR449C Gene

Pathways & Interactions for MIR449C Gene

genes like me logo Genes that share pathways with MIR449C: view

Pathways by source for MIR449C Gene

1 BioSystems pathway for MIR449C Gene

Interacting Proteins for MIR449C Gene

Gene Ontology (GO) - Biological Process for MIR449C Gene

None

No data available for SIGNOR curated interactions for MIR449C Gene

Drugs & Compounds for MIR449C Gene

No Compound Related Data Available

Transcripts for MIR449C Gene

mRNA/cDNA for MIR449C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449C Gene

No ASD Table

Relevant External Links for MIR449C Gene

GeneLoc Exon Structure for
MIR449C
ECgene alternative splicing isoforms for
MIR449C

Expression for MIR449C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR449C Gene:

MIR449C
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR449C Gene

Orthologs for MIR449C Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR449C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-449c 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-449c 34
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir449c 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-449c 34
  • 52 (a)
OneToOne
Species where no ortholog for MIR449C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR449C Gene

ENSEMBL:
Gene Tree for MIR449C (if available)
TreeFam:
Gene Tree for MIR449C (if available)

Paralogs for MIR449C Gene

No data available for Paralogs for MIR449C Gene

Variants for MIR449C Gene

Sequence variations from dbSNP and Humsavar for MIR449C Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1001785608 -- 55,172,453(-) T/G upstream_transcript_variant
rs1003055428 -- 55,174,301(-) C/T upstream_transcript_variant
rs1003727549 -- 55,173,745(-) C/T upstream_transcript_variant
rs1004102690 -- 55,174,002(-) C/T upstream_transcript_variant
rs1004125397 -- 55,172,042(-) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR449C Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Additional Variant Information for MIR449C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR449C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR449C Gene

Disorders for MIR449C Gene

Additional Disease Information for MIR449C

No disorders were found for MIR449C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR449C Gene

Publications for MIR449C Gene

  1. [The establishment of 5637 bladder cancer cell line with stable overexpression of miR-449c]. (PMID: 27371842) Wan P … Chen Z (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2016) 3 58
  2. MiR-449c targets c-Myc and inhibits NSCLC cell progression. (PMID: 23507140) Miao LJ … Wang J (FEBS letters 2013) 3 58
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  4. Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries. (PMID: 19390579) Wyman SK … Tewari M (PloS one 2009) 3 58
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR449C Gene

Sources for MIR449C Gene

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