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Aliases for MIR449B Gene

Subcategory (RNA class) for MIR449B Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR449B Gene

  • MicroRNA 449b 2 3 5
  • Hsa-Mir-449b 3
  • Mir-449b 3
  • MIRN449B 3

External Ids for MIR449B Gene

Previous HGNC Symbols for MIR449B Gene

  • MIRN449B

Previous GeneCards Identifiers for MIR449B Gene

  • GC05M054507
  • GC05M054467
  • GC05M054472
  • GC05M054488

Summaries for MIR449B Gene

Entrez Gene Summary for MIR449B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449B Gene

MIR449B (MicroRNA 449b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and DNA Damage Response.

fRNAdb sequence ontologies for MIR449B Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR449B

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR449B Gene

Genomics for MIR449B Gene

Regulatory Elements for MIR449B Gene

Enhancers for MIR449B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G054900 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +268.6 268564 2.7 PKNOX1 MAX RELA POLR2A EED FOS ETV6 CREM CBFB NR2F1 GPX8 LOC100130990 ENSG00000249016 GZMK MIR449B MIR449A MIR449C CDC20B ENSG00000240535 SNX18
GH05G054906 0.7 ENCODE 10.6 +264.6 264605 0.1 CTCF ZNF654 TEAD1 TEAD4 INSM2 MAFG REST RAD21 YY1 TEAD3 GPX8 ENSG00000249016 GZMK MIR449B MIR449A MIR449C CDC20B ENSG00000240535 LOC100130990 SNX18
GH05G055174 0.9 ENCODE 0.7 -1.5 -1526 0.2 RB1 ZSCAN4 WRNIP1 ARID4B SIN3A BMI1 ZNF2 RAD21 ZEB1 RFX5 GC05M055174 MIR449B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR449B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR449B Gene

Chromosome:
5
Start:
55,170,646 bp from pter
End:
55,170,742 bp from pter
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR449B Gene

Genes around MIR449B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR449B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR449B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449B Gene

ORGUL Member Location for MIR449B Gene

ORGUL Member Location for MIR449B gene

Proteins for MIR449B Gene

Post-translational modifications for MIR449B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449B Gene

Domains & Families for MIR449B Gene

Gene Families for MIR449B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR449B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR449B Gene

Function for MIR449B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR449B Gene

Localization for MIR449B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR449B Gene

Pathways & Interactions for MIR449B Gene

genes like me logo Genes that share pathways with MIR449B: view

Pathways by source for MIR449B Gene

Interacting Proteins for MIR449B Gene

Gene Ontology (GO) - Biological Process for MIR449B Gene

None

No data available for SIGNOR curated interactions for MIR449B Gene

Transcripts for MIR449B Gene

fRNAdb Secondary structures for MIR449B Gene

  • hsa-miR-449b-3p_MIMAT0009203_Homo_sapiens_miR-449b-3p_mature
  • hsa-mir-449b_MI0003673_Homo_sapiens_miR-449b_stem-loop_hairpin

mRNA/cDNA for MIR449B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449B Gene

No ASD Table

Relevant External Links for MIR449B Gene

GeneLoc Exon Structure for
MIR449B
ECgene alternative splicing isoforms for
MIR449B

Expression for MIR449B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR449B Gene:

MIR449B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR449B Gene

Orthologs for MIR449B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR449B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-449b 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-449b 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir449b 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-449b 35 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-449b 35
  • 65 (a)
OneToOne
Species where no ortholog for MIR449B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR449B Gene

ENSEMBL:
Gene Tree for MIR449B (if available)
TreeFam:
Gene Tree for MIR449B (if available)

Paralogs for MIR449B Gene

No data available for Paralogs for MIR449B Gene

Variants for MIR449B Gene

Sequence variations from dbSNP and Humsavar for MIR449B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000390144 -- 55,170,864(+) CTTCA(A/G)GACTA intron-variant, upstream-variant-2KB
rs1000759722 -- 55,171,151(+) TCTAT(A/T)AAAAA intron-variant, upstream-variant-2KB
rs1001054977 -- 55,170,260(+) TTAAA(C/T)ACTGT intron-variant, downstream-variant-500B
rs1001785608 -- 55,172,453(+) TTTTT(G/T)TAGTA intron-variant, upstream-variant-2KB
rs1004125397 -- 55,172,042(+) TAAAG(A/C)AGATG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR449B Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Relevant External Links for MIR449B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR449B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR449B Gene

Disorders for MIR449B Gene

Relevant External Links for MIR449B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR449B

No disorders were found for MIR449B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR449B Gene

Publications for MIR449B Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p/c-Met axis. (PMID: 26242266) Zhen L. … Yi-Long Y. (Tumour Biol. 2016) 3 64
  3. Regulation of MET-mediated proliferation of thyroid carcinoma cells by miR-449b. (PMID: 26044563) Chen L. … Wang G. (Tumour Biol. 2015) 3 64
  4. miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. (PMID: 26055141) Zhang P. … Wang M. (Tumour Biol. 2015) 3 64
  5. miR-449b inhibits the proliferation of SW1116 colon cancer stem cells through downregulation of CCND1 and E2F3 expression. (PMID: 23674142) Fang Y. … Chen Z. (Oncol. Rep. 2013) 3 64

Products for MIR449B Gene

Sources for MIR449B Gene

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