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Aliases for MIR449B Gene

Subcategory (RNA class) for MIR449B Gene


Quality Score for this RNA gene is


Aliases for MIR449B Gene

  • MicroRNA 449b 2 3
  • Hsa-Mir-449b 3
  • Mir-449b 3
  • MIRN449B 3

External Ids for MIR449B Gene

Previous HGNC Symbols for MIR449B Gene

  • MIRN449B

Previous GeneCards Identifiers for MIR449B Gene

  • GC05M054507
  • GC05M054467
  • GC05M054472
  • GC05M054488

Summaries for MIR449B Gene

Entrez Gene Summary for MIR449B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449B Gene

MIR449B (MicroRNA 449b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR449B Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR449B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR449B Gene

Genomics for MIR449B Gene

Genomic Location for MIR449B Gene

55,170,646 bp from pter
55,170,742 bp from pter
97 bases
Minus strand

Genomic View for MIR449B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR449B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449B Gene

ORGUL Member Location for MIR449B Gene

ORGUL Member Location for MIR449B gene

No data available for Regulatory Elements for MIR449B Gene

Proteins for MIR449B Gene

Post-translational modifications for MIR449B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449B Gene

Domains & Families for MIR449B Gene

Gene Families for MIR449B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR449B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR449B Gene

Function for MIR449B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR449B Gene

Localization for MIR449B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR449B Gene

Pathways & Interactions for MIR449B Gene

SuperPathways for MIR449B Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR449B: view

Pathways by source for MIR449B Gene

1 BioSystems pathway for MIR449B Gene

Interacting Proteins for MIR449B Gene

Gene Ontology (GO) - Biological Process for MIR449B Gene


No data available for SIGNOR curated interactions for MIR449B Gene

Drugs & Compounds for MIR449B Gene

No Compound Related Data Available

Transcripts for MIR449B Gene

fRNAdb Secondary structures for MIR449B Gene

  • hsa-miR-449b-3p_MIMAT0009203_Homo_sapiens_miR-449b-3p_mature
  • hsa-mir-449b_MI0003673_Homo_sapiens_miR-449b_stem-loop_hairpin

mRNA/cDNA for MIR449B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449B Gene

No ASD Table

Relevant External Links for MIR449B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR449B Gene

No Expression Related Data Available

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR449B Gene

Orthologs for MIR449B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR449B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-449b 36
  • 97 (a)
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
(Mus musculus)
Mammalia Mir449b 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-449b 36
  • 69 (a)
oan-mir-449b 36
  • 69 (a)
(Pan troglodytes)
Mammalia ptr-mir-449b 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-449b 36
  • 65 (a)
Species with no ortholog for MIR449B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR449B Gene

Gene Tree for MIR449B (if available)
Gene Tree for MIR449B (if available)

Paralogs for MIR449B Gene

No data available for Paralogs for MIR449B Gene

Variants for MIR449B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR449B Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV Gain 17160897

Relevant External Links for MIR449B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR449B Gene

Disorders for MIR449B Gene

Relevant External Links for MIR449B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR449B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR449B Gene

Publications for MIR449B Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 67
  2. miR-449b inhibits the proliferation of SW1116 colon cancer stem cells through downregulation of CCND1 and E2F3 expression. (PMID: 23674142) Fang Y. … Chen Z. (Oncol. Rep. 2013) 67
  3. MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma. (PMID: 24120948) Martin A. … Laurie N.A. (Biochem. Biophys. Res. Commun. 2013) 67
  4. Small RNA profiling of influenza A virus-infected cells identifies miR-449b as a regulator of histone deacetylase 1 and interferon beta. (PMID: 24086750) Buggele W.A. … Horvath C.M. (PLoS ONE 2013) 67
  5. [miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line]. (PMID: 21321636) Ma L.p. … Zhang Q. (Beijing Da Xue Xue Bao 2011) 67

Products for MIR449B Gene

Sources for MIR449B Gene

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