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Aliases for MIR449A Gene

Subcategory (RNA class) for MIR449A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR449A Gene

  • MicroRNA 449a 2 3 5
  • MicroRNA 449 2 3
  • Hsa-Mir-449a 3
  • Hsa-Mir-449 3
  • Mir-449a 3
  • MIRN449A 3
  • MIRN449 3

External Ids for MIR449A Gene

Previous HGNC Symbols for MIR449A Gene

  • MIRN449
  • MIRN449A

Previous GeneCards Identifiers for MIR449A Gene

  • GC05M054506
  • GC05M054466

Summaries for MIR449A Gene

Entrez Gene Summary for MIR449A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449A Gene

MIR449A (MicroRNA 449a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR449A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR449A Gene

Genomics for MIR449A Gene

Genomic Location for MIR449A Gene

Chromosome:
5
Start:
55,170,532 bp from pter
End:
55,170,622 bp from pter
Size:
91 bases
Orientation:
Minus strand

Genomic View for MIR449A Gene

Genes around MIR449A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR449A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR449A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449A Gene

ORGUL Member Location for MIR449A Gene

ORGUL Member Location for MIR449A gene

No data available for Regulatory Elements for MIR449A Gene

Proteins for MIR449A Gene

Post-translational modifications for MIR449A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449A Gene

Domains & Families for MIR449A Gene

Gene Families for MIR449A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR449A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR449A Gene

Function for MIR449A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR449A Gene

Localization for MIR449A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR449A Gene

Pathways & Interactions for MIR449A Gene

genes like me logo Genes that share pathways with MIR449A: view

Pathways by source for MIR449A Gene

1 BioSystems pathway for MIR449A Gene
1 KEGG pathway for MIR449A Gene

Interacting Proteins for MIR449A Gene

Gene Ontology (GO) - Biological Process for MIR449A Gene

None

No data available for SIGNOR curated interactions for MIR449A Gene

Drugs & Compounds for MIR449A Gene

No Compound Related Data Available

Transcripts for MIR449A Gene

mRNA/cDNA for MIR449A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449A Gene

No ASD Table

Relevant External Links for MIR449A Gene

GeneLoc Exon Structure for
MIR449A
ECgene alternative splicing isoforms for
MIR449A

Expression for MIR449A Gene

mRNA expression in normal human tissues for MIR449A Gene

genes like me logo Genes that share expression patterns with MIR449A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR449A Gene

Orthologs for MIR449A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR449A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-449a 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-449a 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-449 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir449a 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-449a 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
oan-mir-449a 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-449a 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-449a 36
  • 72 (a)
OneToOne
Species with no ortholog for MIR449A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR449A Gene

ENSEMBL:
Gene Tree for MIR449A (if available)
TreeFam:
Gene Tree for MIR449A (if available)

Paralogs for MIR449A Gene

No data available for Paralogs for MIR449A Gene

Variants for MIR449A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR449A Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV Gain 17160897

Relevant External Links for MIR449A Gene

HapMap Linkage Disequilibrium report
MIR449A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR449A Gene

Disorders for MIR449A Gene

Relevant External Links for MIR449A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR449A

No disorders were found for MIR449A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR449A Gene

Publications for MIR449A Gene

  1. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. (PMID: 15735639) Xie X. … Kellis M. (Nature 2005) 1 3
  2. miR-449a targets Flot2 and inhibits gastric cancer invasion by inhibiting TGF-I^-mediated EMT. (PMID: 26576674) Li Q. … Liu T. (Diagn Pathol 2015) 3
  3. MicroRNA-449a reduces cell survival and enhances cisplatin-induced cytotoxicity via downregulation of NOTCH1 in ovarian cancer cells. (PMID: 25179844) Zhou Y. … Li H. (Tumour Biol. 2014) 3
  4. MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1. (PMID: 25119660) Zhang H. … Zhang J. (Int. J. Oncol. 2014) 3
  5. Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. (PMID: 24810364) Zhang E.B. … Chen J.f. (Oncotarget 2014) 3

Products for MIR449A Gene

Sources for MIR449A Gene

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