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Aliases for MIR449A Gene

Subcategory (RNA class) for MIR449A Gene


Quality Score for this RNA gene is


Aliases for MIR449A Gene

  • MicroRNA 449a 2 3 5
  • MicroRNA 449 2 3
  • Hsa-Mir-449a 3
  • Hsa-Mir-449 3
  • Mir-449a 3
  • MIRN449A 3
  • MIRN449 3

External Ids for MIR449A Gene

Previous HGNC Symbols for MIR449A Gene

  • MIRN449
  • MIRN449A

Previous GeneCards Identifiers for MIR449A Gene

  • GC05M054506
  • GC05M054466

Summaries for MIR449A Gene

Entrez Gene Summary for MIR449A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449A Gene

MIR449A (MicroRNA 449a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and DNA damage response.

fRNAdb sequence ontologies for MIR449A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR449A Gene

Genomics for MIR449A Gene

Regulatory Elements for MIR449A Gene

Enhancers for MIR449A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F054906 0.6 ENCODE 10.6 +264.5 264485 0.1 CTCF ZNF654 TEAD1 TEAD4 INSM2 MAFG REST RAD21 TEAD3 ZNF316 GPX8 ENSG00000249016 CDC20B MIR449C MIR449A MIR449B GZMK ENSG00000240535 LOC100130990 SNX18
GH05F054900 0.8 FANTOM5 Ensembl ENCODE 10.6 +268.5 268454 2.7 PKNOX1 BHLHE40 ZBED1 CBFB MAX JUNB TBX21 GABPA RELA SMARCA4 GPX8 LOC100130990 ENSG00000249016 MIR449A MIR449B CDC20B MIR449C GZMK ENSG00000240535 SNX18
GH05F055162 0.5 ENCODE 0.4 +7.8 7775 0.2 USF2 CCNO LOC105378973 SNX18 GPX8 MIR449A
GH05F055159 0.4 ENCODE 0.4 +9.8 9832 2.4 TBP INSM2 SIN3A FEZF1 ZNF2 RAD21 RFX5 ZNF366 RCOR1 ZNF263 CCNO LOC105378973 ENSG00000249016 LOC100130990 SNX18 CDC20B GPX8 MIR449A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR449A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR449A Gene

55,170,532 bp from pter
55,170,622 bp from pter
91 bases
Minus strand

Genomic View for MIR449A Gene

Genes around MIR449A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR449A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR449A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449A Gene

ORGUL Member Location for MIR449A Gene

ORGUL Member Location for MIR449A gene

Proteins for MIR449A Gene

Post-translational modifications for MIR449A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449A Gene

Domains & Families for MIR449A Gene

Gene Families for MIR449A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR449A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR449A Gene

Function for MIR449A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR449A Gene

Localization for MIR449A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR449A Gene

Pathways & Interactions for MIR449A Gene

genes like me logo Genes that share pathways with MIR449A: view

Pathways by source for MIR449A Gene

2 BioSystems pathways for MIR449A Gene
1 KEGG pathway for MIR449A Gene

Interacting Proteins for MIR449A Gene

Gene Ontology (GO) - Biological Process for MIR449A Gene


No data available for SIGNOR curated interactions for MIR449A Gene

Transcripts for MIR449A Gene

mRNA/cDNA for MIR449A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449A Gene

No ASD Table

Relevant External Links for MIR449A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR449A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR449A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR449A Gene:

genes like me logo Genes that share expression patterns with MIR449A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR449A Gene

Orthologs for MIR449A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR449A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-449a 35
  • 97 (a)
(Canis familiaris)
Mammalia cfa-mir-449 35
  • 93 (a)
(Bos Taurus)
Mammalia bta-mir-449a 35
  • 91 (a)
(Mus musculus)
Mammalia Mir449a 35
  • 86 (a)
(Monodelphis domestica)
Mammalia mdo-mir-449a 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-449a 35
  • 63 (a)
-- 35
  • 62 (a)
(Gallus gallus)
Aves gga-mir-449a 35
  • 76 (a)
(Anolis carolinensis)
Reptilia aca-mir-449a 35
  • 72 (a)
Species where no ortholog for MIR449A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR449A Gene

Gene Tree for MIR449A (if available)
Gene Tree for MIR449A (if available)

Paralogs for MIR449A Gene

No data available for Paralogs for MIR449A Gene

Variants for MIR449A Gene

Sequence variations from dbSNP and Humsavar for MIR449A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10061133 -- 55,170,716(+) CTAAC(A/G)ATACA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111416873 -- 55,171,205(+) CTACT(C/G)AGGAG intron-variant, upstream-variant-2KB
rs112310158 -- 55,170,550(+) AGACA(A/G)CAGTT intron-variant, nc-transcript-variant, downstream-variant-500B
rs112705432 -- 55,172,266(+) TGCTT(C/T)TGAAT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs113400974 -- 55,170,427(+) ATTAT(A/G)AGCTA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR449A Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Relevant External Links for MIR449A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR449A Gene

Disorders for MIR449A Gene

Relevant External Links for MIR449A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR449A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR449A Gene

Publications for MIR449A Gene

  1. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. (PMID: 15735639) Xie X. … Kellis M. (Nature 2005) 1 3 64
  2. MiR-29c regulates the expression of miR-34c and miR-449a by targeting DNA methyltransferase 3a and 3b in nasopharyngeal carcinoma. (PMID: 26975503) Niu M. … Peng S. (BMC Cancer 2016) 3 64
  3. MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein. (PMID: 25487955) Yao Y. … Liu Y. (Mol Oncol 2015) 3 64
  4. microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest. (PMID: 25760387) Zhao Z. … Du L. (RNA Biol 2015) 3 64
  5. miRNA-449a is downregulated in osteosarcoma and promotes cell apoptosis by targeting BCL2. (PMID: 26002578) Chen J. … Li H. (Tumour Biol. 2015) 3 64

Products for MIR449A Gene

Sources for MIR449A Gene

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