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Aliases for MIR449A Gene

Subcategory (RNA class) for MIR449A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR449A Gene

  • MicroRNA 449a 2 3
  • MicroRNA 449 2 3
  • MIRN449A 3 6
  • Hsa-Mir-449a 3
  • Hsa-Mir-449 3
  • MIRN449 3

External Ids for MIR449A Gene

Previous HGNC Symbols for MIR449A Gene

  • MIRN449
  • MIRN449A

Previous GeneCards Identifiers for MIR449A Gene

  • GC05M054506
  • GC05M054466

Summaries for MIR449A Gene

Entrez Gene Summary for MIR449A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449A Gene

MIR449A (MicroRNA 449a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR449A include hepatitis c virus. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR449A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR449A Gene

Genomics for MIR449A Gene

Genomic Location for MIR449A Gene

Start:
55,170,532 bp from pter
End:
55,170,622 bp from pter
Size:
91 bases
Orientation:
Minus strand

Genomic View for MIR449A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR449A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449A Gene

ORGUL Member Location for MIR449A Gene

ORGUL Member Location for MIR449A gene

No data available for Regulatory Elements for MIR449A Gene

Proteins for MIR449A Gene

Post-translational modifications for MIR449A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449A Gene

Domains for MIR449A Gene

Gene Families for MIR449A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR449A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR449A Gene

Function for MIR449A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR449A Gene

Localization for MIR449A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR449A Gene

Pathways for MIR449A Gene

genes like me logo Genes that share pathways with MIR449A: view

Pathways by source for MIR449A Gene

1 BioSystems pathway for MIR449A Gene
1 KEGG pathway for MIR449A Gene

Interacting Proteins for MIR449A Gene

Gene Ontology (GO) - Biological Process for MIR449A Gene

None

Transcripts for MIR449A Gene

mRNA/cDNA for MIR449A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR449A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449A Gene

No ASD Table

Relevant External Links for MIR449A Gene

GeneLoc Exon Structure for
MIR449A
ECgene alternative splicing isoforms for
MIR449A

Expression for MIR449A Gene

mRNA expression in normal human tissues for MIR449A Gene

genes like me logo Genes that share expressions with MIR449A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR449A Gene

Orthologs for MIR449A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR449A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-449a 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-449 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-449a 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir449a 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
oan-mir-449a 36
  • 63 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-449a 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-449a 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-449a 36
  • 72 (a)
OneToOne
Species with no ortholog for MIR449A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR449A Gene

ENSEMBL:
Gene Tree for MIR449A (if available)
TreeFam:
Gene Tree for MIR449A (if available)

Paralogs for MIR449A Gene

No data available for Paralogs for MIR449A Gene

Variants for MIR449A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR449A Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV Gain 17160897

Relevant External Links for MIR449A Gene

HapMap Linkage Disequilibrium report
MIR449A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR449A Gene

Disorders for MIR449A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR449A Gene in MalaCards »

(1) Diseases for MIR449A Gene including...

genes like me logo Genes that share disorders with MIR449A: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR449A Gene

Publications for MIR449A Gene

  1. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. (PMID: 15735639) Xie X. … Kellis M. (Nature 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. miR-449a targets HDAC-1 and induces growth arrest in prostate cancer. (PMID: 19252524) Noonan E.J. … Dahiya R. (Oncogene 2009) 3
  5. E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis. (PMID: 19960022) LizAc M. … Dobbelstein M. (Cell Death Differ. 2010) 3

Products for MIR449A Gene

Sources for MIR449A Gene

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