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Aliases for MIR449A Gene

Subcategory (RNA class) for MIR449A Gene


Quality Score for this RNA gene is


Aliases for MIR449A Gene

  • MicroRNA 449a 2 3 5
  • MicroRNA 449 2 3
  • Hsa-Mir-449a 3
  • Hsa-Mir-449 3
  • Mir-449a 3
  • MIRN449A 3
  • MIRN449 3

External Ids for MIR449A Gene

Previous HGNC Symbols for MIR449A Gene

  • MIRN449
  • MIRN449A

Previous GeneCards Identifiers for MIR449A Gene

  • GC05M054506
  • GC05M054466

Summaries for MIR449A Gene

Entrez Gene Summary for MIR449A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449A Gene

MIR449A (MicroRNA 449a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and DNA Damage Response.

fRNAdb sequence ontologies for MIR449A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

Additional gene information for MIR449A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR449A Gene

Genomics for MIR449A Gene

Regulatory Elements for MIR449A Gene

Enhancers for MIR449A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H054900 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +268.4 268444 2.7 PKNOX1 MAX BATF RELA POLR2A EED FOS ETV6 RUNX3 CREM GPX8 LOC100130990 ENSG00000249016 MIR449A MIR449B GZMK MIR449C CDC20B ENSG00000240535 SNX18
GH05H054906 0.7 ENCODE 10.6 +264.5 264485 0.1 CTCF ZNF654 TEAD1 INSM2 MAFG REST RAD21 YY1 TEAD3 ZNF316 GPX8 ENSG00000249016 MIR449A MIR449B GZMK CDC20B MIR449C ENSG00000240535 LOC100130990 SNX18
GH05H055159 0.9 ENCODE 0.4 +9.8 9832 2.4 TBP INSM2 SIN3A BRCA1 ZNF2 RAD21 RFX5 ZNF366 RCOR1 SMARCA5 CCNO LOC105378973 ENSG00000249016 LOC100130990 SNX18 CDC20B GPX8 MIR449A
GH05H055162 0.4 ENCODE 0.4 +7.8 7775 0.2 USF2 LOC105378973 CCNO SNX18 GPX8 MIR449A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR449A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR449A Gene

Genomic Locations for MIR449A Gene
91 bases
Minus strand

Genomic View for MIR449A Gene

Genes around MIR449A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR449A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR449A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449A Gene

ORGUL Member Location for MIR449A Gene

ORGUL Member Location for MIR449A gene

Proteins for MIR449A Gene

Post-translational modifications for MIR449A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449A Gene

Domains & Families for MIR449A Gene

Gene Families for MIR449A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR449A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR449A Gene

Function for MIR449A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR449A Gene

Localization for MIR449A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR449A Gene

Pathways & Interactions for MIR449A Gene

genes like me logo Genes that share pathways with MIR449A: view

Pathways by source for MIR449A Gene

1 KEGG pathway for MIR449A Gene

Interacting Proteins for MIR449A Gene

Gene Ontology (GO) - Biological Process for MIR449A Gene


No data available for SIGNOR curated interactions for MIR449A Gene

Drugs & Compounds for MIR449A Gene

No Compound Related Data Available

Transcripts for MIR449A Gene

mRNA/cDNA for MIR449A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449A Gene

No ASD Table

Relevant External Links for MIR449A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR449A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR449A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR449A Gene:

genes like me logo Genes that share expression patterns with MIR449A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR449A Gene

Orthologs for MIR449A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR449A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-449a 34
  • 97 (a)
(Canis familiaris)
Mammalia cfa-mir-449 34
  • 93 (a)
(Bos Taurus)
Mammalia bta-mir-449a 34
  • 91 (a)
(Mus musculus)
Mammalia Mir449a 34
  • 86 (a)
(Monodelphis domestica)
Mammalia mdo-mir-449a 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-449a 34
  • 63 (a)
-- 34
  • 62 (a)
(Gallus gallus)
Aves gga-mir-449a 34
  • 76 (a)
(Anolis carolinensis)
Reptilia aca-mir-449a 34
  • 72 (a)
Species where no ortholog for MIR449A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR449A Gene

Gene Tree for MIR449A (if available)
Gene Tree for MIR449A (if available)

Paralogs for MIR449A Gene

No data available for Paralogs for MIR449A Gene

Variants for MIR449A Gene

Sequence variations from dbSNP and Humsavar for MIR449A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000390144 -- 55,170,864(+) CTTCA(A/G)GACTA intron-variant, upstream-variant-2KB
rs1000759722 -- 55,171,151(+) TCTAT(A/T)AAAAA intron-variant, upstream-variant-2KB
rs1001054977 -- 55,170,260(+) TTAAA(C/T)ACTGT intron-variant, downstream-variant-500B
rs1001785608 -- 55,172,453(+) TTTTT(G/T)TAGTA intron-variant, upstream-variant-2KB
rs1004125397 -- 55,172,042(+) TAAAG(A/C)AGATG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR449A Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Relevant External Links for MIR449A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR449A Gene

Disorders for MIR449A Gene

Relevant External Links for MIR449A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR449A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR449A Gene

Publications for MIR449A Gene

  1. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. (PMID: 15735639) Xie X … Kellis M (Nature 2005) 1 3 60
  2. Characterizing isomiR variants within the microRNA-34/449 family. (PMID: 28192603) Mercey O … Marcet B (FEBS letters 2017) 3 60
  3. miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells. (PMID: 26520443) Mao A … Zhang H (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  4. MiR-449a promotes breast cancer progression by targeting CRIP2. (PMID: 26934316) Shi W … Liu FF (Oncotarget 2016) 3 60
  5. MiR-29c regulates the expression of miR-34c and miR-449a by targeting DNA methyltransferase 3a and 3b in nasopharyngeal carcinoma. (PMID: 26975503) Niu M … Peng S (BMC cancer 2016) 3 60

Products for MIR449A Gene

Sources for MIR449A Gene

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