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Aliases for MIR4499 Gene

Subcategory (RNA class) for MIR4499 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4499 Gene

  • MicroRNA 4499 2 3 5
  • Hsa-Mir-4499 3

External Ids for MIR4499 Gene

Previous GeneCards Identifiers for MIR4499 Gene

  • GC13U900858
  • GC13M021008

Summaries for MIR4499 Gene

Entrez Gene Summary for MIR4499 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4499 Gene

MIR4499 (MicroRNA 4499) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4499 Gene

Genomics for MIR4499 Gene

Regulatory Elements for MIR4499 Gene

Enhancers for MIR4499 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G020418 1.5 Ensembl ENCODE dbSUPER 0.4 +14.0 13991 1.9 SIN3A BRCA1 TCF12 ZNF121 CBX5 FOS JUNB TBX21 MAFF SMARCA4 CRYL1 MIR4499 LOC105370102
GH13G020428 0.7 dbSUPER 0.7 +3.5 3507 3.7 PKNOX1 MAFG MAX RAD21 ZNF316 CEBPA NFE2L1 NFE2 HNF4A EMSY CRYL1 MIR4499 LOC105370102
GH13G020474 1.5 FANTOM5 Ensembl ENCODE 0.3 -42.2 -42162 3.2 TBL1XR1 INSM2 FEZF1 ZNF2 EGR1 SCRT2 ETV6 IKZF2 CREM EGR2 CRYL1 IFT88 MIR4499
GH13G020441 1 ENCODE dbSUPER 0.4 -8.8 -8780 1.6 PKNOX1 SIN3A FEZF1 CEBPG EBF1 ZNF335 FOSL1 GATA2 ZNF600 FOS CRYL1 MIR4499
GH13G020414 1 Ensembl ENCODE dbSUPER 0.4 +18.8 18804 1.5 FOSL1 GTF2F1 RBBP5 EGR2 CRYL1 GJB2 MIR4499 LOC105370102
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4499 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4499 Gene

Chromosome:
13
Start:
20,433,778 bp from pter
End:
20,433,846 bp from pter
Size:
69 bases
Orientation:
Minus strand

Genomic View for MIR4499 Gene

Genes around MIR4499 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4499 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4499 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4499 Gene

Proteins for MIR4499 Gene

Post-translational modifications for MIR4499 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4499 Gene

Domains & Families for MIR4499 Gene

Gene Families for MIR4499 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4499: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4499 Gene

Function for MIR4499 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4499 Gene

Localization for MIR4499 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4499 Gene

Pathways & Interactions for MIR4499 Gene

SuperPathways for MIR4499 Gene

No Data Available

Interacting Proteins for MIR4499 Gene

Gene Ontology (GO) - Biological Process for MIR4499 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4499 Gene

Drugs & Compounds for MIR4499 Gene

No Compound Related Data Available

Transcripts for MIR4499 Gene

mRNA/cDNA for MIR4499 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4499 Gene

No ASD Table

Relevant External Links for MIR4499 Gene

GeneLoc Exon Structure for
MIR4499
ECgene alternative splicing isoforms for
MIR4499

Expression for MIR4499 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4499 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4499 Gene:

MIR4499
genes like me logo Genes that share expression patterns with MIR4499: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4499 Gene

Orthologs for MIR4499 Gene

Evolution for MIR4499 Gene

ENSEMBL:
Gene Tree for MIR4499 (if available)
TreeFam:
Gene Tree for MIR4499 (if available)

No data available for Orthologs for MIR4499 Gene

Paralogs for MIR4499 Gene

No data available for Paralogs for MIR4499 Gene

Variants for MIR4499 Gene

Sequence variations from dbSNP and Humsavar for MIR4499 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1005536975 -- 20,434,388(+) TCGGG(C/G/T)CTCTG intron-variant, upstream-variant-2KB
rs1005653400 -- 20,434,641(+) TGCAG(C/T)GTTAA intron-variant, upstream-variant-2KB
rs1006506002 -- 20,434,070(+) TCATG(C/T)GGGTT intron-variant, upstream-variant-2KB
rs1006897641 -- 20,433,637(+) GAAAC(G/T)CTTAA intron-variant, downstream-variant-500B
rs1007107103 -- 20,434,316(+) CAAGA(C/G)GATTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4499 Gene

Variant ID Type Subtype PubMed ID
dgv1612n100 CNV loss 25217958
dgv221n27 CNV loss 19166990
dgv3072n54 CNV loss 21841781
dgv3075n54 CNV loss 21841781
esv2751132 CNV loss 17911159
esv2759925 CNV loss 17122850
esv34984 CNV loss 17911159
esv3892301 CNV loss 25118596
esv3892302 CNV loss 25118596
nsv1046946 CNV gain 25217958
nsv1078303 OTHER inversion 25765185
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv818947 CNV loss 17921354

Relevant External Links for MIR4499 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4499

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4499 Gene

Disorders for MIR4499 Gene

Relevant External Links for MIR4499

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4499

No disorders were found for MIR4499 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4499 Gene

Publications for MIR4499 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4499 Gene

Sources for MIR4499 Gene

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