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Aliases for MIR4498 Gene

Subcategory (RNA class) for MIR4498 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4498 Gene

  • MicroRNA 4498 2 3 5
  • Hsa-Mir-4498 3
  • Mir-4498 3

External Ids for MIR4498 Gene

Previous GeneCards Identifiers for MIR4498 Gene

  • GC12U901601
  • GC12M120595

Summaries for MIR4498 Gene

Entrez Gene Summary for MIR4498 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4498 Gene

MIR4498 (MicroRNA 4498) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4498 Gene

Genomics for MIR4498 Gene

Regulatory Elements for MIR4498 Gene

Enhancers for MIR4498 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F120125 0.7 Ensembl ENCODE 0.3 +28.7 28670 2.3 PKNOX1 ESRRA RFX1 JUN MAX EBF1 POLR2A SCRT2 KDM1A MYC PXN-AS1 RPLP0 GCN1 PXN RAB35 MIR4498
GH12F120181 0.7 ENCODE 0.3 -27.1 -27103 2.0 PKNOX1 RFX5 EGR2 ZNF362 NFYC CEBPB ZEB2 TSHZ1 TGIF2 ZNF341 PXN GCN1 MIR4498
GH12F120131 0.2 ENCODE 0.3 +22.8 22833 2.7 TBP MXI1 USF1 TBL1XR1 BMI1 EBF1 RELA ZFHX2 EGR1 POLR2A GCN1 COQ5 RAB35 MIR4498
GH12F120139 0.5 ENCODE 0.3 +15.2 15176 1.0 RAB35 GCN1 MIR4498
GH12F120136 0.6 ENCODE 0.3 +19.0 18988 0.1 PAF1 ESRRA DPF2 ZNF217 E2F1 CTBP1 GATA3 POLR2A RCOR1 ZBTB33 RAB35 MIR4498
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4498 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4498 Gene

Chromosome:
12
Start:
120,155,434 bp from pter
End:
120,155,499 bp from pter
Size:
66 bases
Orientation:
Minus strand

Genomic View for MIR4498 Gene

Genes around MIR4498 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4498 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4498 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4498 Gene

ORGUL Member Location for MIR4498 Gene

ORGUL Member Location for MIR4498 gene

Proteins for MIR4498 Gene

Post-translational modifications for MIR4498 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4498 Gene

Domains & Families for MIR4498 Gene

Gene Families for MIR4498 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4498: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4498 Gene

Function for MIR4498 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4498 Gene

Localization for MIR4498 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4498 Gene

Pathways & Interactions for MIR4498 Gene

SuperPathways for MIR4498 Gene

No Data Available

Interacting Proteins for MIR4498 Gene

Gene Ontology (GO) - Biological Process for MIR4498 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4498 Gene

Transcripts for MIR4498 Gene

mRNA/cDNA for MIR4498 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4498 Gene

No ASD Table

Relevant External Links for MIR4498 Gene

GeneLoc Exon Structure for
MIR4498
ECgene alternative splicing isoforms for
MIR4498

Expression for MIR4498 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4498 Gene:

MIR4498
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4498 Gene

Orthologs for MIR4498 Gene

Evolution for MIR4498 Gene

ENSEMBL:
Gene Tree for MIR4498 (if available)
TreeFam:
Gene Tree for MIR4498 (if available)

No data available for Orthologs for MIR4498 Gene

Paralogs for MIR4498 Gene

No data available for Paralogs for MIR4498 Gene

Variants for MIR4498 Gene

Sequence variations from dbSNP and Humsavar for MIR4498 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs112562164 -- 120,157,005(+) AGAAC(A/G)GCAGG intron-variant, upstream-variant-2KB
rs115443884 -- 120,157,372(+) CTCTT(C/G)GTGAG intron-variant, upstream-variant-2KB
rs116561504 -- 120,156,400(+) TCATG(C/T)AATTT intron-variant, upstream-variant-2KB
rs140664704 -- 120,155,305(+) GGTAA(C/T)GTGCC downstream-variant-500B, reference, missense
rs142900939 -- 120,155,560(+) GATGC(A/G)GCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4498 Gene

Variant ID Type Subtype PubMed ID
nsv519657 CNV loss 19592680
nsv560433 CNV loss 21841781
nsv832530 CNV loss 17160897

Relevant External Links for MIR4498 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4498

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4498 Gene

Disorders for MIR4498 Gene

Relevant External Links for MIR4498

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4498

No disorders were found for MIR4498 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4498 Gene

Publications for MIR4498 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4498 Gene

Sources for MIR4498 Gene

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