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Aliases for MIR4497 Gene

Subcategory (RNA class) for MIR4497 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4497 Gene

  • MicroRNA 4497 2 3 5
  • Hsa-Mir-4497 3
  • Mir-4497 3

External Ids for MIR4497 Gene

Previous GeneCards Identifiers for MIR4497 Gene

  • GC12U901598
  • GC12P110272

Summaries for MIR4497 Gene

Entrez Gene Summary for MIR4497 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4497 Gene

MIR4497 (MicroRNA 4497) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4497 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4497 Gene

Genomics for MIR4497 Gene

Regulatory Elements for MIR4497 Gene

Enhancers for MIR4497 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H109827 1.3 FANTOM5 Ensembl ENCODE 0.7 -4.8 -4786 1.7 HDGF CTCF ZSCAN4 PAX8 CDC5L SP1 ZNF121 TARDBP IKZF1 NBN GIT2 ANKRD13A GLTP MIR4497 FAM222A-AS1
GH12H109822 1.1 FANTOM5 ENCODE 0.4 -10.3 -10263 1.3 ELF3 FOXA2 MLX DNMT3B RARA GLIS2 FOS SP5 ZHX2 TGIF2 TRPV4 MIR4497 FAM222A-AS1
GH12H109820 0.8 ENCODE 0.4 -12.2 -12218 0.9 INSM2 KLF17 ZNF366 ZSCAN5C SCRT2 ZNF362 ZEB2 ZNF398 ZNF341 GLIS1 MIR4497 FAM222A-AS1
GH12H109818 0.7 ENCODE 0.4 -14.2 -14199 1 FOXA2 KLF17 PAX8 ZIC2 CTBP1 ADNP ZNF600 SMARCE1 ZC3H11A ZNF398 MIR4497 FAM222A-AS1
GH12H109805 0.8 ENCODE 0.3 -27.9 -27898 0.2 CTCF ZNF792 RB1 ARID4B MAX CEBPG ZNF2 RAD21 RELA ZBTB48 MIR4497 FAM222A-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4497 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4497 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057222 52 801 ZFHX2 POLR2A GLIS1 ZMYM3 ELF1 ZNF24 KDM1A

Genomic Locations for MIR4497 Gene

Genomic Locations for MIR4497 Gene
chr12:109,833,348-109,833,436
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr12:110,271,153-110,271,241
(GRCh37/hg19)

Genomic View for MIR4497 Gene

Genes around MIR4497 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4497 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4497 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4497 Gene

Proteins for MIR4497 Gene

Post-translational modifications for MIR4497 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4497 Gene

Domains & Families for MIR4497 Gene

Gene Families for MIR4497 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4497: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4497 Gene

Function for MIR4497 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4497 Gene

Localization for MIR4497 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4497 Gene

Pathways & Interactions for MIR4497 Gene

SuperPathways for MIR4497 Gene

No Data Available

Interacting Proteins for MIR4497 Gene

Gene Ontology (GO) - Biological Process for MIR4497 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4497 Gene

Drugs & Compounds for MIR4497 Gene

No Compound Related Data Available

Transcripts for MIR4497 Gene

mRNA/cDNA for MIR4497 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4497 Gene

No ASD Table

Relevant External Links for MIR4497 Gene

GeneLoc Exon Structure for
MIR4497
ECgene alternative splicing isoforms for
MIR4497

Expression for MIR4497 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4497 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4497 Gene

This gene is overexpressed in Minor Salivary Gland (x10.9), Esophagus - Mucosa (x6.4), and Kidney - Cortex (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR4497 Gene:

MIR4497
genes like me logo Genes that share expression patterns with MIR4497: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4497 Gene

Orthologs for MIR4497 Gene

Evolution for MIR4497 Gene

ENSEMBL:
Gene Tree for MIR4497 (if available)
TreeFam:
Gene Tree for MIR4497 (if available)

No data available for Orthologs for MIR4497 Gene

Paralogs for MIR4497 Gene

No data available for Paralogs for MIR4497 Gene

Variants for MIR4497 Gene

Sequence variations from dbSNP and Humsavar for MIR4497 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs56079803 Likely benign 109,833,413(+) CCCGC(C/T)CGGCG nc-transcript-variant, upstream-variant-2KB
rs886048942 Uncertain significance 109,833,392(-) TTCAG(A/G)AAGCG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000648757 -- 109,832,927(+) GAAGC(C/T)TTTGG intron-variant, upstream-variant-2KB
rs1002233901 -- 109,833,429(+) CCGCC(C/T)GCGGG nc-transcript-variant, upstream-variant-2KB
rs1004426480 -- 109,833,468(+) CGCGC(A/G)CCGCC downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR4497 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4497

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4497 Gene

Disorders for MIR4497 Gene

Relevant External Links for MIR4497

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4497

No disorders were found for MIR4497 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4497 Gene

Publications for MIR4497 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 60
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4497 Gene

Sources for MIR4497 Gene

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