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Aliases for MIR4496 Gene

Subcategory (RNA class) for MIR4496 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4496 Gene

  • MicroRNA 4496 2 3 5
  • Hsa-Mir-4496 3

External Ids for MIR4496 Gene

Previous GeneCards Identifiers for MIR4496 Gene

  • GC12U901588
  • GC12P109023
  • GC12P108628

Summaries for MIR4496 Gene

Entrez Gene Summary for MIR4496 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4496 Gene

MIR4496 (MicroRNA 4496) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4496 Gene

Genomics for MIR4496 Gene

Regulatory Elements for MIR4496 Gene

Enhancers for MIR4496 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F108640 0.9 FANTOM5 Ensembl ENCODE 8.2 +17.1 17057 10.5 ATF1 PKNOX1 ARNT SIN3A ZNF121 CBX5 GATA2 FOS NCOA1 REST RNU7-169P MIR4496 CORO1C FOXN4 MVK SELPLG SSH1 GC12P108645
GH12F108687 1.7 FANTOM5 Ensembl ENCODE 8.1 +64.5 64498 10.5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS CORO1C ALKBH2 SART3 RNU7-169P MIR4496 MVK SSH1 GC12P108678 GC12P108720
GH12F108726 0.5 ENCODE 8.1 +102.4 102419 9.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 RNU7-169P SSH1 SELPLG RNU4-32P CORO1C MIR4496 ACACB FOXN4 GC12M108717
GH12F108626 0.8 FANTOM5 ENCODE 8 +4.8 4759 13.4 MLX CREB3L1 ZFP64 DMAP1 FEZF1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 SART3 PWP1 UBE3B PRDM4 CORO1C FICD SELPLG TMEM119 RPL17P38 RNU7-169P
GH12F108663 1.4 FANTOM5 Ensembl ENCODE 8 +37.6 37569 6.3 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ELK1 ZNF143 CORO1C SELPLG SSH1 ISCU SART3 MIR4496 MVK ACACB RNU7-169P GC12P108645
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4496 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4496 Gene

Chromosome:
12
Start:
108,628,687 bp from pter
End:
108,641,318 bp from pter
Size:
12,632 bases
Orientation:
Plus strand

Genomic View for MIR4496 Gene

Genes around MIR4496 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4496 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4496 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4496 Gene

Proteins for MIR4496 Gene

Post-translational modifications for MIR4496 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4496 Gene

Domains & Families for MIR4496 Gene

Gene Families for MIR4496 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4496: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4496 Gene

Function for MIR4496 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4496 Gene

Localization for MIR4496 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4496 Gene

Pathways & Interactions for MIR4496 Gene

SuperPathways for MIR4496 Gene

No Data Available

Interacting Proteins for MIR4496 Gene

Gene Ontology (GO) - Biological Process for MIR4496 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4496 Gene

Transcripts for MIR4496 Gene

mRNA/cDNA for MIR4496 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4496 Gene

No ASD Table

Relevant External Links for MIR4496 Gene

GeneLoc Exon Structure for
MIR4496
ECgene alternative splicing isoforms for
MIR4496

Expression for MIR4496 Gene

mRNA expression in normal human tissues for MIR4496 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4496 Gene

This gene is overexpressed in Whole Blood (x9.5) and Spleen (x7.5).

NURSA nuclear receptor signaling pathways regulating expression of MIR4496 Gene:

MIR4496
genes like me logo Genes that share expression patterns with MIR4496: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4496 Gene

Orthologs for MIR4496 Gene

Evolution for MIR4496 Gene

ENSEMBL:
Gene Tree for MIR4496 (if available)
TreeFam:
Gene Tree for MIR4496 (if available)

No data available for Orthologs for MIR4496 Gene

Paralogs for MIR4496 Gene

No data available for Paralogs for MIR4496 Gene

Variants for MIR4496 Gene

Sequence variations from dbSNP and Humsavar for MIR4496 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs114567965 -- 108,635,737(+) GCAAA(A/G)CCTCA intron-variant, upstream-variant-2KB
rs138874221 -- 108,634,628(+) TCCTG(C/T)GGTGA intron-variant, upstream-variant-2KB
rs140249053 -- 108,635,634(+) TTTCA(A/T)AAAGT intron-variant, upstream-variant-2KB
rs142023424 -- 108,634,156(+) ACAGT(C/T)GGGGC intron-variant, upstream-variant-2KB
rs1420661 -- 108,636,164(-) CAGGA(G/T)GATTG intron-variant, nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4496 Gene

Variant ID Type Subtype PubMed ID
nsv883 CNV deletion 18451855

Relevant External Links for MIR4496 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4496

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4496 Gene

Disorders for MIR4496 Gene

Relevant External Links for MIR4496

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4496

No disorders were found for MIR4496 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4496 Gene

Publications for MIR4496 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4496 Gene

Sources for MIR4496 Gene

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