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Aliases for MIR4494 Gene

Subcategory (RNA class) for MIR4494 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4494 Gene

  • MicroRNA 4494 2 3 5
  • Hsa-Mir-4494 3

External Ids for MIR4494 Gene

Previous GeneCards Identifiers for MIR4494 Gene

  • GC12U901596
  • GC12M047759

Summaries for MIR4494 Gene

Entrez Gene Summary for MIR4494 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4494 Gene

MIR4494 (MicroRNA 4494) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4494 Gene

Genomics for MIR4494 Gene

Regulatory Elements for MIR4494 Gene

Enhancers for MIR4494 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F047359 1.6 FANTOM5 Ensembl ENCODE 0.8 +3.0 2963 3.4 PKNOX1 ATF1 SIN3A GATA2 ZNF143 DEK ZNF263 NCOA1 REST TBX21 PCED1B HDAC7 MIR4494 ENSG00000257924
GH12F047365 0.9 Ensembl 0.8 -1.7 -1733 0.8 ELF3 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF335 GLIS2 KLF13 LOC100506099 MIR4494 ENSG00000257906
GH12F047354 1.5 FANTOM5 Ensembl ENCODE 0.4 +7.8 7792 3.0 HDAC1 ESRRA TAL1 MAX ZNF175 ZNF23 ZFHX2 EED ETV6 NR2F6 ENSG00000257924 MIR4494
GH12F047376 1.3 Ensembl ENCODE 0.4 -14.0 -14018 2.7 PKNOX1 ATF1 ARNT CREB3L1 ZFP64 SIN3A YY1 ZNF121 GATA2 ZNF143 ENSG00000199566 AMIGO2 ENSG00000257924 PCED1B MIR4494 ENSG00000257906
GH12F047390 1.5 FANTOM5 Ensembl ENCODE 0.3 -28.7 -28658 3.9 HDAC1 ATF1 PKNOX1 TBL1XR1 FEZF1 ZBTB40 ZNF121 ZNF366 CREM TFDP1 ENSG00000199566 AMIGO2 PHBP18 PCED1B ENSG00000257906 MIR4494
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4494 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4494 Gene

Chromosome:
12
Start:
47,364,186 bp from pter
End:
47,364,269 bp from pter
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR4494 Gene

Genes around MIR4494 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4494 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4494 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4494 Gene

Proteins for MIR4494 Gene

Post-translational modifications for MIR4494 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4494 Gene

Domains & Families for MIR4494 Gene

Gene Families for MIR4494 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4494: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4494 Gene

Function for MIR4494 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4494 Gene

Localization for MIR4494 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4494 Gene

Pathways & Interactions for MIR4494 Gene

SuperPathways for MIR4494 Gene

No Data Available

Interacting Proteins for MIR4494 Gene

Gene Ontology (GO) - Biological Process for MIR4494 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4494 Gene

Transcripts for MIR4494 Gene

mRNA/cDNA for MIR4494 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4494 Gene

No ASD Table

Relevant External Links for MIR4494 Gene

GeneLoc Exon Structure for
MIR4494
ECgene alternative splicing isoforms for
MIR4494

Expression for MIR4494 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4494 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4494 Gene:

MIR4494
genes like me logo Genes that share expression patterns with MIR4494: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4494 Gene

Orthologs for MIR4494 Gene

Evolution for MIR4494 Gene

ENSEMBL:
Gene Tree for MIR4494 (if available)
TreeFam:
Gene Tree for MIR4494 (if available)

No data available for Orthologs for MIR4494 Gene

Paralogs for MIR4494 Gene

No data available for Paralogs for MIR4494 Gene

Variants for MIR4494 Gene

Sequence variations from dbSNP and Humsavar for MIR4494 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11183902 -- 47,365,097(+) AAAAC(A/G)GACCA intron-variant, upstream-variant-2KB
rs112028978 -- 47,365,808(+) GACTC(C/T)ACCCC intron-variant, upstream-variant-2KB
rs112517038 -- 47,365,514(+) CTAAT(G/T)TTTGT intron-variant, upstream-variant-2KB
rs113011274 -- 47,364,978(+) TATGA(A/G)TGTGT intron-variant, upstream-variant-2KB
rs113980975 -- 47,366,067(+) GAGTG(A/G)CCTGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4494 Gene

Variant ID Type Subtype PubMed ID
nsv558785 CNV gain 21841781
esv3892198 CNV gain 25118596

Relevant External Links for MIR4494 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4494

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4494 Gene

Disorders for MIR4494 Gene

Relevant External Links for MIR4494

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4494

No disorders were found for MIR4494 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4494 Gene

Publications for MIR4494 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4494 Gene

Sources for MIR4494 Gene

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