Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4492 Gene

Subcategory (RNA class) for MIR4492 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4492 Gene

  • MicroRNA 4492 2 3 5
  • Hsa-Mir-4492 3
  • Mir-4492 3

External Ids for MIR4492 Gene

Previous GeneCards Identifiers for MIR4492 Gene

  • GC11U901865
  • GC11P118783

Summaries for MIR4492 Gene

Entrez Gene Summary for MIR4492 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4492 Gene

MIR4492 (MicroRNA 4492) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4492 Gene

Genomics for MIR4492 Gene

Regulatory Elements for MIR4492 Gene

Enhancers for MIR4492 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G118906 2.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +8.1 8085 24.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC BCL9L CCDC84 CXCR5 DPAGT1 HMBS ENSG00000222529 FOXR1 C2CD2L ENSG00000254909 RNF26
GH11G118898 0.5 ENCODE dbSUPER 0.4 -12.6 -12552 0.0 GC11P118898 MIR4492
GH11G118897 0.5 ENCODE dbSUPER 0.4 -12.8 -12782 0.2 GC11P118898 MIR4492
GH11G118903 0.4 dbSUPER 0.4 -7.0 -7021 1.2 ZNF316 EMSY UPK2 ENSG00000222529 FOXR1 CCDC84 ENSG00000255121 HMBS H2AFX C2CD2L DPAGT1 GC11P118898
GH11G118904 0.4 dbSUPER 0.4 -5.8 -5786 1.2 ZNF664 ZNF316 UPK2 ENSG00000222529 FOXR1 CCDC84 ENSG00000255121 HMBS H2AFX C2CD2L DPAGT1 TRAPPC4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4492 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4492 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000266128 -108 401 HDAC1 TBP CBX3 PTBP1 SIN3A DMAP1 RAD21 GLIS2 RCOR1 FOS
ENSR00000045703 -1208 201 SIN3A RAD21 GLIS2 ZNF366 ZEB2 ZNF398 MEF2D PRDM6 ZNF341 MYNN

Genomic Location for MIR4492 Gene

Chromosome:
11
Start:
118,910,708 bp from pter
End:
118,910,787 bp from pter
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR4492 Gene

Genes around MIR4492 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4492 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4492 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4492 Gene

Proteins for MIR4492 Gene

Post-translational modifications for MIR4492 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4492 Gene

Domains & Families for MIR4492 Gene

Gene Families for MIR4492 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4492: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4492 Gene

Function for MIR4492 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4492 Gene

Localization for MIR4492 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4492 Gene

Pathways & Interactions for MIR4492 Gene

SuperPathways for MIR4492 Gene

No Data Available

Interacting Proteins for MIR4492 Gene

Gene Ontology (GO) - Biological Process for MIR4492 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4492 Gene

Drugs & Compounds for MIR4492 Gene

No Compound Related Data Available

Transcripts for MIR4492 Gene

mRNA/cDNA for MIR4492 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4492 Gene

No ASD Table

Relevant External Links for MIR4492 Gene

GeneLoc Exon Structure for
MIR4492
ECgene alternative splicing isoforms for
MIR4492

Expression for MIR4492 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4492 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4492 Gene:

MIR4492
genes like me logo Genes that share expression patterns with MIR4492: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4492 Gene

Orthologs for MIR4492 Gene

Evolution for MIR4492 Gene

ENSEMBL:
Gene Tree for MIR4492 (if available)
TreeFam:
Gene Tree for MIR4492 (if available)

No data available for Orthologs for MIR4492 Gene

Paralogs for MIR4492 Gene

No data available for Paralogs for MIR4492 Gene

Variants for MIR4492 Gene

Sequence variations from dbSNP and Humsavar for MIR4492 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000607410 -- 118,911,250(+) GTCTT(C/G)GGCCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002664513 -- 118,909,149(+) GACAG(A/T)GGGAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1002912030 -- 118,910,067(+) GTGTC(A/G)GAGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1003375279 -- 118,910,382(+) CCCCT(C/T)GTGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1003842069 -- 118,909,414(+) CATCA(A/C)GGGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4492 Gene

Variant ID Type Subtype PubMed ID
nsv952743 CNV deletion 24416366

Relevant External Links for MIR4492 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4492

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4492 Gene

Disorders for MIR4492 Gene

Relevant External Links for MIR4492

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4492

No disorders were found for MIR4492 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4492 Gene

Publications for MIR4492 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4492 Gene

Sources for MIR4492 Gene

Content
Loading form....