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Aliases for MIR4491 Gene

Subcategory (RNA class) for MIR4491 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4491 Gene

  • MicroRNA 4491 2 3 5
  • Hsa-Mir-4491 3
  • Mir-4491 3

External Ids for MIR4491 Gene

Previous GeneCards Identifiers for MIR4491 Gene

  • GC11U901870
  • GC11P111220

Summaries for MIR4491 Gene

Entrez Gene Summary for MIR4491 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4491 Gene

MIR4491 (MicroRNA 4491) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4491 Gene

Genomics for MIR4491 Gene

Regulatory Elements for MIR4491 Gene

Enhancers for MIR4491 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F111357 1.6 FANTOM5 Ensembl ENCODE 0.3 +17.1 17148 15.7 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B YBX1 FEZF1 DMAP1 ZNF2 COLCA2 COLCA1 LAYN BTG4 C11orf88 MIR34B MIR34C POU2AF1 MIR4491 RNU2-60P
GH11F111333 1.2 Ensembl ENCODE 0.4 -12.2 -12193 3.5 ATF1 MLX ARID4B DMAP1 YY1 ZNF121 SP5 MIER2 REST PPARG COLCA1 COLCA2 MIR4491 LOC105369491
GH11F111352 0.6 ENCODE 0.4 +5.4 5419 1.6 CTCF STAT1 RAD21 ZFHX2 ZNF366 POLR2A ETV6 EGR2 COLCA1 COLCA2 RNU2-60P MIR4491
GH11F111331 0.8 Ensembl ENCODE 0.3 -15.6 -15605 1.3 JUND MTA2 SCRT2 IKZF1 JUNB RAD21 COLCA2 COLCA1 LOC105369491 MIR4491
GH11F111327 0.8 Ensembl ENCODE 0.3 -19.6 -19603 0.7 ZNF664 GATA3 STAT1 NR3C1 FEZF1 ZIC2 COLCA1 LOC105369491 MIR4491
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4491 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4491 Gene

Chromosome:
11
Start:
111,347,757 bp from pter
End:
111,347,824 bp from pter
Size:
68 bases
Orientation:
Plus strand

Genomic View for MIR4491 Gene

Genes around MIR4491 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4491 Gene

Proteins for MIR4491 Gene

Post-translational modifications for MIR4491 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4491 Gene

Domains & Families for MIR4491 Gene

Gene Families for MIR4491 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4491: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4491 Gene

Function for MIR4491 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4491 Gene

Localization for MIR4491 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4491 Gene

Pathways & Interactions for MIR4491 Gene

SuperPathways for MIR4491 Gene

No Data Available

Interacting Proteins for MIR4491 Gene

Gene Ontology (GO) - Biological Process for MIR4491 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4491 Gene

Transcripts for MIR4491 Gene

mRNA/cDNA for MIR4491 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4491 Gene

No ASD Table

Relevant External Links for MIR4491 Gene

GeneLoc Exon Structure for
MIR4491
ECgene alternative splicing isoforms for
MIR4491

Expression for MIR4491 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4491 Gene:

MIR4491
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4491 Gene

Orthologs for MIR4491 Gene

Evolution for MIR4491 Gene

ENSEMBL:
Gene Tree for MIR4491 (if available)
TreeFam:
Gene Tree for MIR4491 (if available)

No data available for Orthologs for MIR4491 Gene

Paralogs for MIR4491 Gene

No data available for Paralogs for MIR4491 Gene

Variants for MIR4491 Gene

Sequence variations from dbSNP and Humsavar for MIR4491 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111245443 -- 111,347,732(+) TTGAA(-/T)AATAC upstream-variant-2KB
rs113387106 -- 111,346,422(+) CAGTC(C/T)TATAT upstream-variant-2KB
rs115771768 -- 111,345,840(+) TGTGG(C/T)TACAG upstream-variant-2KB
rs116573029 -- 111,347,441(+) AACCA(C/T)TGATG upstream-variant-2KB
rs117143574 -- 111,346,716(+) AAGTC(A/G)TCAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4491 Gene

Variant ID Type Subtype PubMed ID
esv2666308 CNV deletion 23128226
esv3627735 CNV loss 21293372
esv3627736 CNV loss 21293372
esv3627737 CNV gain 21293372
nsv490 CNV deletion 18451855
nsv832268 CNV loss 17160897

Relevant External Links for MIR4491 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4491

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4491 Gene

Disorders for MIR4491 Gene

Relevant External Links for MIR4491

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4491

No disorders were found for MIR4491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4491 Gene

Publications for MIR4491 Gene

  1. Identification of cardiac-related circulating microRNA profile in human chronic heart failure. (PMID: 26683101) Li H. … Wang D.W. (Oncotarget 2016) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4491 Gene

Sources for MIR4491 Gene

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