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Aliases for MIR4487 Gene

Subcategory (RNA class) for MIR4487 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4487 Gene

  • MicroRNA 4487 2 3 5
  • Hsa-Mir-4487 3
  • Mir-4487 3

External Ids for MIR4487 Gene

Previous GeneCards Identifiers for MIR4487 Gene

  • GC11U901878

Summaries for MIR4487 Gene

Entrez Gene Summary for MIR4487 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4487 Gene

MIR4487 (MicroRNA 4487) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4487 Gene

Genomics for MIR4487 Gene

Regulatory Elements for MIR4487 Gene

Enhancers for MIR4487 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F047399 1.3 FANTOM5 ENCODE 0.8 -0.2 -210 2.5 HDGF HDAC1 PKNOX1 WRNIP1 ZBTB40 ZNF2 ZEB1 GLIS2 ELK1 EGR1 SPI1 PSMC3 FNBP4 ENSG00000255197 MADD C11orf49 CELF1 MIR4487
GH11F047405 0.8 Ensembl 0.8 +4.7 4731 0.2 KLF1 KLF17 SIN3A ZNF2 ZNF48 ZNF335 ZNF121 ZFHX2 KLF7 ZBTB20 SLC39A13 MIR4487
GH11F047403 0.6 Ensembl 0.8 +2.5 2531 1.0 ARID1B BCOR ZNF512 ZNF175 ZMYM3 ZNF652 C1QTNF4 MADD FNBP4 ENSG00000255197 PSMC3 SLC39A13 MIR4487
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4487 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4487 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001768582 -670 1001 HDGF WRNIP1 ZBTB40 ZNF2 ZEB1 ELK1 EGR1 SMARCA5 ZBTB11 REST

Genomic Location for MIR4487 Gene

Chromosome:
11
Start:
47,400,970 bp from pter
End:
47,401,042 bp from pter
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR4487 Gene

Genes around MIR4487 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4487 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4487 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4487 Gene

Proteins for MIR4487 Gene

Post-translational modifications for MIR4487 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4487 Gene

Domains & Families for MIR4487 Gene

Gene Families for MIR4487 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4487: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4487 Gene

Function for MIR4487 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4487 Gene

Localization for MIR4487 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4487 Gene

Pathways & Interactions for MIR4487 Gene

SuperPathways for MIR4487 Gene

No Data Available

Interacting Proteins for MIR4487 Gene

Gene Ontology (GO) - Biological Process for MIR4487 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4487 Gene

Transcripts for MIR4487 Gene

mRNA/cDNA for MIR4487 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4487 Gene

No ASD Table

Relevant External Links for MIR4487 Gene

GeneLoc Exon Structure for
MIR4487
ECgene alternative splicing isoforms for
MIR4487

Expression for MIR4487 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4487 Gene:

MIR4487
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4487 Gene

Orthologs for MIR4487 Gene

Evolution for MIR4487 Gene

ENSEMBL:
Gene Tree for MIR4487 (if available)
TreeFam:
Gene Tree for MIR4487 (if available)

No data available for Orthologs for MIR4487 Gene

Paralogs for MIR4487 Gene

No data available for Paralogs for MIR4487 Gene

Variants for MIR4487 Gene

Sequence variations from dbSNP and Humsavar for MIR4487 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10838703 -- 47,401,310(+) GCCCA(C/G)TGATA downstream-variant-500B
rs112950968 -- 47,399,456(+) CTCCC(A/G)GGTTC upstream-variant-2KB
rs113444761 -- 47,400,664(+) TGGGG(A/G)GGGGA upstream-variant-2KB
rs113524130 -- 47,401,036(+) CTGAA(A/G)GGCAG nc-transcript-variant
rs113795919 -- 47,400,660(+) GGTGT(-/G)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4487 Gene

Variant ID Type Subtype PubMed ID
nsv832141 CNV loss 17160897
nsv825871 CNV gain 20364138
nsv554210 CNV loss 21841781
nsv1138018 CNV deletion 24896259
esv2744437 CNV deletion 23290073

Relevant External Links for MIR4487 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4487

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4487 Gene

Disorders for MIR4487 Gene

Relevant External Links for MIR4487

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4487

No disorders were found for MIR4487 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4487 Gene

Publications for MIR4487 Gene

  1. Identification of ULK1 as a novel biomarker involved in miR-4487 and miR-595 regulation in neuroblastoma SH-SY5Y cell autophagy. (PMID: 26183158) Chen Y. … Liu B. (Sci Rep 2015) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4487 Gene

Sources for MIR4487 Gene

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