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Aliases for MIR4485 Gene

Subcategory (RNA class) for MIR4485 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4485 Gene

  • MicroRNA 4485 2 3
  • MTRNR2L8 4 5
  • MT-RNR2-Like Protein 8 4
  • MT-RNR2-Like 8 5
  • Hsa-Mir-4485 3
  • Mir-4485 3
  • HN8 4

External Ids for MIR4485 Gene

Previous GeneCards Identifiers for MIR4485 Gene

  • GC11U901877
  • GC11M010542
  • GC11M010549
  • GC11M010516
  • GC11M010523
  • GC11M010545
  • GC11M010557

Summaries for MIR4485 Gene

Entrez Gene Summary for MIR4485 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4485 Gene

MIR4485 (MicroRNA 4485) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is MTRNR2L12.

UniProtKB/Swiss-Prot for MIR4485 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4485 Gene

Genomics for MIR4485 Gene

Regulatory Elements for MIR4485 Gene

Enhancers for MIR4485 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F010454 0.2 ENCODE 10.6 +51.9 51920 6.4 HDGF PKNOX1 ATF1 ARNT WRNIP1 SIN3A YY1 CBX5 ELK1 GATA2 CTR9 AMPD3 MIR4485 MTRNR2L8 RPL21P97 LYVE1 MRVI1 GC11M010466 GC11P010430
GH11F010449 0.9 ENCODE 10.6 +57.9 57851 3.2 HDGF TBP CTCF ZNF146 MAX EBF1 RAD21 ZBTB48 POLR2A SMC3 AMPD3 CTR9 MTRNR2L8 MIR4485 LYVE1 MRVI1 GC11M010466 GC11P010430
GH11F010650 0.2 ENCODE 10.6 -141.7 -141657 0.7 LYVE1 MRVI1 MIR4485 MTRNR2L8 GC11M010667
GH11F010651 1.1 FANTOM5 Ensembl ENCODE 10.6 -147.6 -147573 9.9 PKNOX1 WRNIP1 SIN3A YY1 FOS DEK SP5 JUNB REST SMARCB1 MRVI1 LOC101928053 LYVE1 CTR9 MIR4485 MTRNR2L8 MRVI1-AS1 ADM GC11M010667
GH11F010536 0.5 ENCODE 10.4 -27.2 -27214 0.7 LYVE1 MRVI1 MIR4485 MTRNR2L8 RNF141 GC11M010556 GC11M010563
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4485 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4485 Gene

Chromosome:
11
Start:
10,507,887 bp from pter
End:
10,509,189 bp from pter
Size:
1,303 bases
Orientation:
Minus strand

Genomic View for MIR4485 Gene

Genes around MIR4485 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4485 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4485 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4485 Gene

Proteins for MIR4485 Gene

  • Protein details for MIR4485 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ75-HMN8_HUMAN
    Recommended name:
    Humanin-like 8
    Protein Accession:
    P0CJ75

    Protein attributes for MIR4485 Gene

    Size:
    24 amino acids
    Molecular mass:
    2661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIR4485 Gene

Post-translational modifications for MIR4485 Gene

No Post-translational modifications

Other Protein References for MIR4485 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR4485 Gene

Domains & Families for MIR4485 Gene

Gene Families for MIR4485 Gene

Protein Domains for MIR4485 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0CJ75

UniProtKB/Swiss-Prot:

HMN8_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MIR4485: view

No data available for Suggested Antigen Peptide Sequences for MIR4485 Gene

Function for MIR4485 Gene

Molecular function for MIR4485 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4485 Gene

Localization for MIR4485 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4485 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MIR4485 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MIR4485: view

No data available for Subcellular locations from COMPARTMENTS for MIR4485 Gene

Pathways & Interactions for MIR4485 Gene

SuperPathways for MIR4485 Gene

No Data Available

Interacting Proteins for MIR4485 Gene

Gene Ontology (GO) - Biological Process for MIR4485 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4485 Gene

Transcripts for MIR4485 Gene

mRNA/cDNA for MIR4485 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4485 Gene

No ASD Table

Relevant External Links for MIR4485 Gene

GeneLoc Exon Structure for
MIR4485
ECgene alternative splicing isoforms for
MIR4485

Expression for MIR4485 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4485 Gene:

MIR4485

mRNA Expression by UniProt/SwissProt for MIR4485 Gene:

P0CJ75-HMN8_HUMAN
Tissue specificity: Highly expressed in the kidney, heart muscle and testis. Not expressed in skeletal muscle.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4485 Gene

Orthologs for MIR4485 Gene

Evolution for MIR4485 Gene

ENSEMBL:
Gene Tree for MIR4485 (if available)
TreeFam:
Gene Tree for MIR4485 (if available)

No data available for Orthologs for MIR4485 Gene

Paralogs for MIR4485 Gene

Paralogs for MIR4485 Gene

genes like me logo Genes that share paralogs with MIR4485: view

Variants for MIR4485 Gene

Sequence variations from dbSNP and Humsavar for MIR4485 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111966168 -- 10,508,515(+) CTGAT(A/G)TAGGC upstream-variant-2KB, utr-variant-5-prime
rs112117100 -- 10,508,498(+) CAGTT(C/T)AATAT upstream-variant-2KB, utr-variant-5-prime
rs113018605 -- 10,507,969(+) AATTA(A/G)ACGTG downstream-variant-500B, utr-variant-3-prime
rs113641511 -- 10,508,635(+) TTTAG(A/G)TGACA upstream-variant-2KB, utr-variant-5-prime
rs11489841 -- 10,509,205(+) AAGTT(A/G)AGTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4485 Gene

Variant ID Type Subtype PubMed ID
esv22967 CNV gain 19812545
esv3625358 CNV gain 21293372
nsv1044011 CNV gain 25217958
nsv972946 CNV duplication 23825009
nsv975881 CNV duplication 23825009

Relevant External Links for MIR4485 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4485

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4485 Gene

Disorders for MIR4485 Gene

Relevant External Links for MIR4485

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4485

No disorders were found for MIR4485 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4485 Gene

Publications for MIR4485 Gene

  1. Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients. (PMID: 25201637) Fan H.M. … Lu J. (J Psychiatr Res 2014) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  4. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 4 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4485 Gene

Sources for MIR4485 Gene

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