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Aliases for MIR448 Gene

Subcategory (RNA class) for MIR448 Gene


Quality Score for this RNA gene is


Aliases for MIR448 Gene

  • MicroRNA 448 2 3 5
  • Hsa-Mir-448 3
  • MiRNA448 3
  • MIRN448 3

External Ids for MIR448 Gene

ORGUL Members for MIR448 Gene

Previous HGNC Symbols for MIR448 Gene

  • MIRN448

Previous GeneCards Identifiers for MIR448 Gene

  • GC0XP113964
  • GC0XP114058

Summaries for MIR448 Gene

Entrez Gene Summary for MIR448 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR448 Gene

MIR448 (MicroRNA 448) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR448 Gene

Genomics for MIR448 Gene

Genomic Location for MIR448 Gene

114,823,454 bp from pter
114,823,564 bp from pter
111 bases
Plus strand

Genomic View for MIR448 Gene

Genes around MIR448 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR448 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR448 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR448 Gene

No data available for Regulatory Elements for MIR448 Gene

Proteins for MIR448 Gene

Post-translational modifications for MIR448 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR448 Gene

Domains & Families for MIR448 Gene

Gene Families for MIR448 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR448: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR448 Gene

Function for MIR448 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR448 Gene

Localization for MIR448 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR448 Gene

Pathways & Interactions for MIR448 Gene

SuperPathways for MIR448 Gene

No Data Available

Interacting Proteins for MIR448 Gene

Gene Ontology (GO) - Biological Process for MIR448 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR448 Gene

Transcripts for MIR448 Gene

mRNA/cDNA for MIR448 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR448 Gene

No ASD Table

Relevant External Links for MIR448 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR448 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR448 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR448 Gene

Orthologs for MIR448 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR448 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-448 35
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-448 35
  • 93 (a)
(Mus musculus)
Mammalia Mir448 35
  • 90 (a)
(Bos Taurus)
Mammalia bta-mir-448 35
  • 89 (a)
Species where no ortholog for MIR448 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR448 Gene

Gene Tree for MIR448 (if available)
Gene Tree for MIR448 (if available)

Paralogs for MIR448 Gene

No data available for Paralogs for MIR448 Gene

Variants for MIR448 Gene

Sequence variations from dbSNP and Humsavar for MIR448 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111587887 -- 114,823,154(+) GCAGT(C/G)TTTGT intron-variant, upstream-variant-2KB
rs111589836 -- 114,822,102(+) TTGGC(C/T)TCCTA intron-variant, upstream-variant-2KB
rs112217087 -- 114,822,990(+) TTTGG(C/G)AACTA intron-variant, upstream-variant-2KB
rs113323190 -- 114,823,368(+) ATGAC(A/G)GCATT intron-variant, upstream-variant-2KB
rs139547925 -- 114,822,547(+) TTCCA(C/T)TCAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR448 Gene

Variant ID Type Subtype PubMed ID
esv33994 CNV gain+loss 17666407
nsv527347 CNV gain 19592680

Relevant External Links for MIR448 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR448 Gene

Disorders for MIR448 Gene

Relevant External Links for MIR448

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR448 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR448 Gene

Publications for MIR448 Gene

  1. microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. (PMID: 26882564) Correia N.C. … Barata J.T. (Oncotarget 2016) 3 64
  2. Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. (PMID: 26917489) Bamodu O.A. … Chao T.Y. (BMC Cancer 2016) 3 64
  3. Low Expression of miR-448 Induces EMT and Promotes Invasion by Regulating ROCK2 in Hepatocellular Carcinoma. (PMID: 25969175) Zhu H. … Lu J. (Cell. Physiol. Biochem. 2015) 3 64
  4. miR-448 negatively regulates ovarian cancer cell growth and metastasis by targeting CXCL12. (PMID: 26103953) Lv Y. … Fang C. (Clin Transl Oncol 2015) 3 64
  5. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-I_B/microRNA 448 circuit. (PMID: 23504987) Mak K.K. … Yeh C.T. (Mol Nutr Food Res 2013) 3 64

Products for MIR448 Gene

Sources for MIR448 Gene

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