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Aliases for MIR4478 Gene

Subcategory (RNA class) for MIR4478 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4478 Gene

  • MicroRNA 4478 2 3 5
  • Hsa-Mir-4478 3
  • Mir-4478 3

External Ids for MIR4478 Gene

Previous GeneCards Identifiers for MIR4478 Gene

  • GC09U901714
  • GC09M124884

Summaries for MIR4478 Gene

Entrez Gene Summary for MIR4478 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4478 Gene

MIR4478 (MicroRNA 4478) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4478 Gene

Genomics for MIR4478 Gene

Regulatory Elements for MIR4478 Gene

Enhancers for MIR4478 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G122123 0.8 ENCODE 0.7 -3.0 -3000 0.2 BCOR CTCF ESRRA ATF1 ZMYM3 RAD21 TEAD3 EGR1 SMC3 ZNF143 MIR4478 NDUFA8
GH09G122125 1.2 Ensembl ENCODE 0.4 -6.3 -6298 2.8 ELF3 HDGF ATF1 PKNOX1 RB1 ARID4B SIN3A DNMT3B ZNF2 RAD21 TTLL11 MRRF RBM18 PTGS1 OR1K1 MIR4478 NDUFA8
GH09G122106 1.1 dbSUPER 0.4 +12.7 12659 2.5 HDGF PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 TTLL11 ENSG00000261534 MIR4478
GH09G122099 1.4 Ensembl ENCODE 0.3 +20.7 20733 0.7 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 MRRF RBM18 OR1K1 TTLL11 MIR4478
GH09G122116 0.5 ENCODE 0.7 +3.9 3921 0.2 POLR2A TEAD4 RBBP5 ZIC2 MIR4478 TTLL11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4478 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4478 Gene

Chromosome:
9
Start:
122,120,082 bp from pter
End:
122,120,167 bp from pter
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR4478 Gene

Genes around MIR4478 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4478 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4478 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4478 Gene

Proteins for MIR4478 Gene

Post-translational modifications for MIR4478 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4478 Gene

Domains & Families for MIR4478 Gene

Gene Families for MIR4478 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4478: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4478 Gene

Function for MIR4478 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4478 Gene

Localization for MIR4478 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4478 Gene

Pathways & Interactions for MIR4478 Gene

SuperPathways for MIR4478 Gene

No Data Available

Interacting Proteins for MIR4478 Gene

Gene Ontology (GO) - Biological Process for MIR4478 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4478 Gene

Drugs & Compounds for MIR4478 Gene

No Compound Related Data Available

Transcripts for MIR4478 Gene

mRNA/cDNA for MIR4478 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4478 Gene

No ASD Table

Relevant External Links for MIR4478 Gene

GeneLoc Exon Structure for
MIR4478
ECgene alternative splicing isoforms for
MIR4478

Expression for MIR4478 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4478 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4478 Gene:

MIR4478
genes like me logo Genes that share expression patterns with MIR4478: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4478 Gene

Orthologs for MIR4478 Gene

Evolution for MIR4478 Gene

ENSEMBL:
Gene Tree for MIR4478 (if available)
TreeFam:
Gene Tree for MIR4478 (if available)

No data available for Orthologs for MIR4478 Gene

Paralogs for MIR4478 Gene

No data available for Paralogs for MIR4478 Gene

Variants for MIR4478 Gene

Sequence variations from dbSNP and Humsavar for MIR4478 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001634772 -- 122,121,420(+) GCAGA(C/T)ACAGG upstream-variant-2KB
rs1003222493 -- 122,119,761(+) ATGAA(A/C)CTAGA downstream-variant-500B
rs1003255698 -- 122,120,432(+) TGGAT(A/G)CAGGG upstream-variant-2KB
rs1005306034 -- 122,122,111(+) ACAGC(C/T)GGGGA upstream-variant-2KB
rs1005359953 -- 122,121,800(+) GTCCA(G/T)GCAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4478 Gene

Variant ID Type Subtype PubMed ID
dgv7714n100 CNV gain 25217958
esv26681 CNV gain 19812545
nsv1036875 CNV gain 25217958
nsv525442 CNV gain 19592680
nsv831715 CNV gain 17160897

Relevant External Links for MIR4478 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4478

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4478 Gene

Disorders for MIR4478 Gene

Relevant External Links for MIR4478

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4478

No disorders were found for MIR4478 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4478 Gene

Publications for MIR4478 Gene

  1. Application of plasma circulating microRNA-448, 506, 4316, and 4478 analysis for non-invasive diagnosis of lung cancer. (PMID: 26341493) PowrA^zek T. … Milanowski J. (Tumour Biol. 2016) 3 64
  2. Decreased expression of fecal miR-4478 and miR-1295b-3p in early-stage colorectal cancer. (PMID: 25519020) Ghanbari R. … Knuutila S. (Cancer Biomark 2015) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4478 Gene

Sources for MIR4478 Gene

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