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Aliases for MIR4478 Gene

Subcategory (RNA class) for MIR4478 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4478 Gene

  • MicroRNA 4478 2 3 5
  • Hsa-Mir-4478 3
  • Mir-4478 3

External Ids for MIR4478 Gene

Previous GeneCards Identifiers for MIR4478 Gene

  • GC09U901714
  • GC09M124884

Summaries for MIR4478 Gene

Entrez Gene Summary for MIR4478 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4478 Gene

MIR4478 (MicroRNA 4478) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4478 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4478 Gene

Genomics for MIR4478 Gene

GeneHancer (GH) Regulatory Elements for MIR4478 Gene

Promoters and enhancers for MIR4478 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I122123 Enhancer 0.8 ENCODE 0.8 -3.0 -3000 0.2 ATF1 SIN3A RAD21 ARID2 EGR1 ZNF143 RCOR1 ATF7 RUNX3 CREM MIR4478 NDUFA8
GH09I122159 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 0.3 -39.3 -39349 1.8 HDGF CLOCK ATF1 ARNT ARID4B SIN3A DMAP1 ZBTB7B ZNF48 YY1 NDUFA8 MORN5 MIR4478
GH09I122125 Enhancer 1.1 Ensembl ENCODE 0.4 -6.3 -6298 2.8 ELF3 HDGF PKNOX1 ATF1 RB1 ARID4B SIN3A ZNF2 KLF5 DNMT3B TTLL11 RBM18 MRRF PTGS1 OR1K1 MIR4478 NDUFA8
GH09I122116 Enhancer 0.5 ENCODE 0.8 +3.9 3920 0.2 SP1 USF1 POLR2A ZIC2 MIR4478 TTLL11
GH09I122095 Enhancer 0.9 Ensembl ENCODE 0.3 +24.8 24816 0.5 HDAC1 CTCF SAP130 ZFP64 ARID4B SIN3A CEBPG RAD21 ZBTB40 ZNF766 TTLL11 MIR4478
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4478 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4478 Gene

Genomic Locations for MIR4478 Gene
chr9:122,120,082-122,120,167
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand
chr9:124,882,361-124,882,446
(GRCh37/hg19)

Genomic View for MIR4478 Gene

Genes around MIR4478 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4478 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4478 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4478 Gene

Proteins for MIR4478 Gene

Post-translational modifications for MIR4478 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4478 Gene

Domains & Families for MIR4478 Gene

Gene Families for MIR4478 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4478: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4478 Gene

Function for MIR4478 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4478 Gene

Localization for MIR4478 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4478 Gene

Pathways & Interactions for MIR4478 Gene

SuperPathways for MIR4478 Gene

No Data Available

Interacting Proteins for MIR4478 Gene

Gene Ontology (GO) - Biological Process for MIR4478 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4478 Gene

Drugs & Compounds for MIR4478 Gene

No Compound Related Data Available

Transcripts for MIR4478 Gene

mRNA/cDNA for MIR4478 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4478 Gene

No ASD Table

Relevant External Links for MIR4478 Gene

GeneLoc Exon Structure for
MIR4478
ECgene alternative splicing isoforms for
MIR4478

Expression for MIR4478 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4478 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4478 Gene:

MIR4478
genes like me logo Genes that share expression patterns with MIR4478: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4478 Gene

Orthologs for MIR4478 Gene

Evolution for MIR4478 Gene

ENSEMBL:
Gene Tree for MIR4478 (if available)
TreeFam:
Gene Tree for MIR4478 (if available)

No data available for Orthologs for MIR4478 Gene

Paralogs for MIR4478 Gene

No data available for Paralogs for MIR4478 Gene

Variants for MIR4478 Gene

Sequence variations from dbSNP and Humsavar for MIR4478 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001634772 -- 122,121,420(-) T/C upstream_transcript_variant
rs1003222493 -- 122,119,761(-) C/A downstream_transcript_variant
rs1003255698 -- 122,120,432(-) G/A upstream_transcript_variant
rs1005306034 -- 122,122,111(-) C/T upstream_transcript_variant
rs1005359953 -- 122,121,800(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4478 Gene

Variant ID Type Subtype PubMed ID
dgv7714n100 CNV gain 25217958
esv26681 CNV gain 19812545
nsv1036875 CNV gain 25217958
nsv525442 CNV gain 19592680
nsv831715 CNV gain 17160897

Additional Variant Information for MIR4478 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4478

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4478 Gene

Disorders for MIR4478 Gene

Additional Disease Information for MIR4478

No disorders were found for MIR4478 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4478 Gene

Publications for MIR4478 Gene

  1. Application of plasma circulating microRNA-448, 506, 4316, and 4478 analysis for non-invasive diagnosis of lung cancer. (PMID: 26341493) Powrózek T … Milanowski J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58
  2. Decreased expression of fecal miR-4478 and miR-1295b-3p in early-stage colorectal cancer. (PMID: 25519020) Ghanbari R … Knuutila S (Cancer biomarkers : section A of Disease markers 2015) 3 58
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  4. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4478 Gene

Sources for MIR4478 Gene

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