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Aliases for MIR4477B Gene

Subcategory (RNA class) for MIR4477B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4477B Gene

  • MicroRNA 4477b 2 3 5
  • Hsa-Mir-4477b 3

External Ids for MIR4477B Gene

Previous GeneCards Identifiers for MIR4477B Gene

  • GC09U901734
  • GC09P068418
  • GC09P068421
  • GC09P068425

Summaries for MIR4477B Gene

Entrez Gene Summary for MIR4477B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4477B Gene

MIR4477B (MicroRNA 4477b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4477B Gene

Genomics for MIR4477B Gene

Regulatory Elements for MIR4477B Gene

Enhancers for MIR4477B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F063821 1.3 FANTOM5 ENCODE 0.8 +2.4 2376 0.9 CTCF MIR4477B FRG1JP
GH09F063822 0.6 ENCODE 0.8 +3.4 3357 0.6 MIR4477B FRG1JP
GH09F063819 0.2 ENCODE 0.8 -0.1 -53 0.3 DUX4L50 MIR4477B
GH09F063823 0.9 ENCODE 0.8 +3.9 3908 0.2 MIR4477B FRG1JP
GH09F063827 0.2 ENCODE 0.8 +1.8 1778 0.3 CTCF MIR4477B FRG1JP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4477B on UCSC Golden Path with GeneCards custom track

Promoters for MIR4477B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001729569 -1274 201
ENSR00001909062 -1974 401 GATA3

Genomic Location for MIR4477B Gene

Chromosome:
9
Start:
63,819,574 bp from pter
End:
63,819,654 bp from pter
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR4477B Gene

Genes around MIR4477B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4477B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4477B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4477B Gene

Proteins for MIR4477B Gene

Post-translational modifications for MIR4477B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4477B Gene

Domains & Families for MIR4477B Gene

Gene Families for MIR4477B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4477B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4477B Gene

Function for MIR4477B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4477B Gene

Localization for MIR4477B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4477B Gene

Pathways & Interactions for MIR4477B Gene

SuperPathways for MIR4477B Gene

No Data Available

Interacting Proteins for MIR4477B Gene

Gene Ontology (GO) - Biological Process for MIR4477B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4477B Gene

Transcripts for MIR4477B Gene

mRNA/cDNA for MIR4477B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4477B Gene

No ASD Table

Relevant External Links for MIR4477B Gene

GeneLoc Exon Structure for
MIR4477B
ECgene alternative splicing isoforms for
MIR4477B

Expression for MIR4477B Gene

mRNA expression in normal human tissues for MIR4477B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4477B Gene:

MIR4477B
genes like me logo Genes that share expression patterns with MIR4477B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4477B Gene

Orthologs for MIR4477B Gene

Evolution for MIR4477B Gene

ENSEMBL:
Gene Tree for MIR4477B (if available)
TreeFam:
Gene Tree for MIR4477B (if available)

No data available for Orthologs for MIR4477B Gene

Paralogs for MIR4477B Gene

No data available for Paralogs for MIR4477B Gene

Variants for MIR4477B Gene

Sequence variations from dbSNP and Humsavar for MIR4477B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1061921 -- 63,817,987(+) GGAGG(C/T)CTCCG upstream-variant-2KB
rs111251982 -- 63,818,171(+) GCAGG(A/C)CGTCG upstream-variant-2KB
rs111271263 -- 63,819,452(+) ATTAA(A/T)TAATA upstream-variant-2KB
rs111316485 -- 63,818,880(+) CAGAA(A/G)AAAAA upstream-variant-2KB
rs111423473 -- 63,818,827(+) GTTAA(G/T)AGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4477B Gene

Variant ID Type Subtype PubMed ID
dgv4037n106 CNV duplication 24896259
esv2446424 CNV gain 19546169
esv25366 CNV gain+loss 19812545
esv3414582 CNV duplication 20981092
nsv1077550 CNV duplication 25765185
nsv1150753 CNV duplication 26484159
nsv614538 CNV gain 21841781
nsv951484 CNV duplication 24416366
nsv968690 CNV duplication 23825009

Relevant External Links for MIR4477B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4477B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4477B Gene

Disorders for MIR4477B Gene

Relevant External Links for MIR4477B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4477B

No disorders were found for MIR4477B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4477B Gene

Publications for MIR4477B Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4477B Gene

Sources for MIR4477B Gene

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